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Simple painkiller before surgery may cut morphine use

NCT ID NCT07368790

First seen Feb 01, 2026 · Last updated Jun 23, 2026 · Updated 19 times

Summary

This study looked at whether giving paracetamol (a common pain reliever) before a total abdominal hysterectomy could lower the amount of morphine needed after surgery. Forty women aged 30-50 took part. Half received IV paracetamol before surgery, and the other half received a placebo (salt water). The researchers measured how much morphine each group used and their pain scores over 24 hours.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Queen Savang Vadhana Memorial Hospital, Thai Red Cross Society, Jermjomphon street, Chonburi, 20110,

    Chon Buri, Thailand

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

paracetamol (acetaminophen)

What this could lead to

If it works, this could show a simple way to reduce strong painkiller use after surgery.

What could go wrong

This is a small, completed trial with only 40 participants, so results may not apply to everyone. Paracetamol may not significantly reduce morphine needs.

Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.