POSTOPERATIVE PAIN

This study tests a dental procedure for people with a narrow jawbone who need implants. Surgeons will split the bone, place the implant, and cover it with a special growth factor membrane. The goal is to see if this method reduces pain and improves bone and tissue healing around …

This study tests a drug called suzetrigine to see if it can control pain after transvaginal pelvic surgery without using strong opioids. About 120 women will receive either suzetrigine plus standard pain relievers or standard care with opioids. The goal is to see if suzetrigine w…

This study tests whether spraying a numbing medicine (bupivacaine with epinephrine) over the diaphragm during laparoscopic gynecologic surgery can reduce shoulder pain afterward. About 100 women will be randomly assigned to receive the spray or a placebo. The main goal is to see …

This study compares a new under-the-tongue painkiller (sublingual sufentanil) to standard morphine pills for managing pain after surgery. The goal is to see if the new drug helps patients recover their health faster. About 1150 adults having surgery will take part, receiving eith…

This study tests whether rinsing with hydrogen water can reduce inflammation, mouth sores, and pain in people recovering from oral cancer surgery with free flap reconstruction. Thirty-six participants will use either hydrogen water or regular water for oral care over 7 days. Rese…

This study will test whether taking acetaminophen (Tylenol) by mouth works as well as getting it through an IV for pain after lumbar spine fusion surgery. About 180 adults will be randomly assigned to receive either oral or IV acetaminophen for 48 hours after their operation. The…

This study will compare two ultrasound-guided nerve block techniques to manage pain after heart surgery. 80 adults having elective heart surgery will be randomly assigned to receive one of the two blocks. The goal is to see which method reduces opioid use and pain more effectivel…

This study tests whether a combination of a long-acting numbing drug (liposomal bupivacaine) injected into the abdominal wall and a painkiller (oxycodone) given through an IV can help the gut recover faster after major abdominal surgery. The trial will enroll 132 adults having sm…

This study tests whether a combination of two drugs, dexmedetomidine and ketamine, can replace opioids for pain control during kidney stone surgery. Sixty adults undergoing the procedure will receive either the opioid-free combo or standard fentanyl-based anesthesia. Researchers …

This phase 3 trial will test whether a single dose of methadone given at the start of surgery can improve pain control and recovery compared to standard short-acting opioids. About 400 adults having intermediate-risk noncardiac surgery will take part. The main goal is to see if p…

This study looks at whether a nerve block (erector spinae plane block) combined with low-flow anesthesia can improve recovery and reduce opioid use in 72 adults having gallbladder surgery. Participants will be randomly assigned to receive the nerve block plus low-flow anesthesia …

This study tests whether a nerve block called PENG works better than spinal morphine for pain after total hip replacement. 180 adults will be randomly assigned to receive either the PENG block or morphine during spinal anesthesia. The goal is to see if the nerve block reduces the…

This study will compare two types of nerve blocks—Transversalis Fascia Plane Block and M-TAPA—for controlling pain after laparoscopic inguinal hernia repair. Sixty adults aged 18–65 will be randomly assigned to receive one of the blocks before surgery. Researchers will measure pa…

This study tests whether a single 4 mg dose of dexamethasone, given as a shot under the gum before surgery, can reduce pain and difficulty opening the mouth after impacted lower wisdom tooth removal. 268 adults aged 18 to 55 will be randomly assigned to receive the steroid or sta…

This study tests whether listening to music and using Emotional Freedom Techniques (EFT) — a method where you tap on specific points while focusing on your pain — can help people recover better after knee arthroscopy. The goal is to reduce pain, fear of movement, and the risk of …

This early-stage trial will give a single 10 mg dose of psilocybin to 70 adults recovering from trauma surgery who also have opioid use disorder. Researchers want to see if it's safe and practical to give psilocybin in the hospital, and how it affects pain, mood, and opioid use o…

This study compares two types of nerve blocks to see which provides better pain relief after breast cancer surgery that also removes lymph nodes. Sixty women aged 18-65 will receive one of the two blocks before surgery. Researchers will measure pain levels, opioid use, and side e…

This study compares two types of nerve blocks (iPACK and BiFeS) to see which one controls pain better after total knee replacement. One hundred adults having knee surgery will receive one of the two blocks with a numbing medicine (bupivacaine). Researchers will measure pain score…

This study compares two common ultrasound-guided nerve block techniques used to reduce pain and improve recovery after laparoscopic gallbladder removal. 76 adults will receive one of two blocks while under anesthesia. The main goal is to see which method leads to a better recover…

This study tests two different medicines (dexmedetomidine and low-dose ketamine) to see which works better for pain control after weight-loss surgery. About 90 adults will be randomly assigned to receive one of these medicines or a placebo during and after surgery. The goal is to…

This study compares two types of pain blocks used during mastectomy (breast removal surgery) to see which one is easier for doctors to perform and provides better comfort for patients. About 64 adults aged 25-65 having mastectomy will take part. The goal is to improve pain contro…

This study tests whether two types of breathing exercises—pranayama and pursed-lip breathing—can reduce pain, anxiety, and improve vital signs in women after breast surgery. 126 participants will be randomly assigned to one of three groups: pranayama, pursed-lip breathing, or sta…

This study tests a new type of nerve block (r-PVB) to reduce pain and improve recovery after laparoscopic gallbladder removal. About 250 adults having this surgery will either get the new block or standard care. The goal is to see if the block lowers pain scores and helps patient…

This early-stage study tests a new medicine called SYH9089 for pain after abdominal surgery. About 60 adults will receive either the new drug, an active painkiller, or a placebo. Researchers will check safety and how well it controls pain in the first days after surgery.

This study tests a nerve block called M-TAPA to see if it can better control pain after open-heart surgery and reduce the need for strong painkillers like opioids. About 80 adults having elective open-heart surgery will receive either the nerve block plus standard care or standar…

This study tests whether natural medicines (propolis and green tea extract) placed inside the tooth can reduce pain and sudden flare-ups after a root canal retreatment. Forty adults with a failed root canal on a single-rooted tooth will be randomly assigned to get either the stan…

This study will observe 400 adults having minimally invasive left-sided colorectal surgery to see if an extra nerve block during the operation can reduce pain and the need for opioids. The block targets nerves that carry pain signals from the internal organs. Researchers will tra…

This study tests whether a specific type of nerve block (ESP block) can reduce pain and the need for strong painkillers after spinal fusion surgery. 75 adults will be randomly assigned to receive either a standard painkiller (bupivacaine) or a longer-acting version mixed with lip…

This study compares two types of nerve blocks (thoracolumbar interfascial plane block and retrolaminar block) to see which one helps patients recover better after lumbar spine fusion surgery. 70 adults scheduled for surgery will receive one of the two blocks before the procedure.…

This study will compare two types of nerve blocks (M-TAPA and ESP block) to see which provides better pain relief after laparoscopic sleeve gastrectomy. Sixty-four patients will receive an injection of the numbing medicine bupivacaine in one of the two block techniques. Pain scor…

This study tests a combination of a sedative drug (dexmedetomidine) and a local numbing technique (scalp nerve block) to manage pain after brain tumor surgery. The goal is to reduce the need for strong opioid painkillers, which can have side effects. The trial will enroll 2000 ad…

This study looks at whether giving midazolam before surgery or during anesthesia works better for children having their tonsils removed. One hundred kids aged 3-10 will be randomly assigned to receive the drug either as a drink 30 minutes before surgery or through an IV during an…

This study compares two types of nerve blocks (erector spinae plane block and external oblique intercostal plane block) for pain control during and after open gallbladder removal. Sixty-six adults scheduled for surgery will receive one of the two blocks plus standard anesthesia. …

This study compares two types of nerve blocks (SAP and SPSIP) to see which one provides better pain relief after mammoplasty (breast surgery). Sixty women aged 18-85 will receive one of the blocks along with a numbing medicine (bupivacaine). Researchers will measure pain scores, …

This early-stage trial tests a new oral drug called KHN702 for moderate to severe pain after surgery. About 24 adults will receive either the drug or a placebo to see if it is safe and helps reduce pain. The study is double-blind, meaning neither patients nor doctors know who get…

This study tests whether a 5-minute guided breathing technique called box breathing can help older adults (65+) recover from total knee replacement. The goal is to see if it's practical and acceptable for patients to use before and after surgery. Researchers will measure stress h…

This study tests whether applying a mix of numbing drugs and clotting agents directly to surgical wounds can reduce pain and the need for opioid pills after hand surgery. Forty adults having elective hand surgery will be randomly assigned to one of four combinations of these drug…

This study looks at three ways to manage pain after mastectomy: standard pain medication, a nerve block called rhomboid intercostal block (RIB), or a combination of RIB with another nerve block. Researchers will review medical records of 66 women to see which method provides the …

This study will test whether using a small vibration massager can help control pain and reduce the need for opioid painkillers after surgery for a broken wrist. About 100 adults who have had wrist fracture repair will use the device and report their pain levels and medication use…

This study compares two types of nerve blocks (ITPB and EOIPB) to see which provides better pain relief after laparoscopic sleeve gastrectomy. Sixty adults having this weight-loss surgery will be randomly assigned to receive one of the two blocks. The main goal is to measure pain…

This study compares two types of nerve blocks (QIPB and SIFICB) to see which one works better for pain after hip surgery. About 60 adults having hip surgery will take part. The goal is to find which block lowers pain scores and reduces the need for extra pain medicine.

This study tests two simple, drug-free methods—vibration and breathing exercises—to see if they can reduce pain and anxiety when a chest tube is removed after surgery. About 70 adults will be randomly assigned to vibration, breathing exercises, or standard care. If effective, the…

This study looks at whether using a pillow placed behind the shoulder after rotator cuff repair surgery can lower pain and improve sleep. About 126 adults aged 40 to 70 will choose whether to use the pillow or not. Their pain, sleep quality, and shoulder function will be checked …

This study compares two types of nerve blocks (erector spinae plane block vs. external oblique-intercostal plane block) to see which provides better pain relief after open ventral hernia repair. Fifty adults scheduled for surgery will receive one of the two blocks, and researcher…

This study compares two common pain relief methods for people having gallbladder removal surgery. The goal is to see which method better reduces pain and the need for strong painkillers. Sixty adults will be randomly assigned to receive either a local anesthetic injection or an u…

This study will compare two types of nerve blocks to see which one provides better pain relief after video-assisted lung surgery. Sixty adults having planned lung surgery will receive one of the two blocks. The main goal is to measure pain levels and the amount of extra pain medi…

This study compares two different volumes of the same painkiller (bupivacaine) given as a TAP block after cesarean section. The goal is to see if a larger volume provides better pain relief without increasing side effects. Fifty full-term mothers having planned C-sections will ta…

This study tests whether a special numbing medicine (liposomal bupivacaine) injected near the hip before surgery can control pain for up to 72 hours after hip fracture surgery in people aged 55 and older. The goal is to reduce pain, lower the need for strong painkillers like opio…

This study compares two numbing techniques (RIB and PVB) to control pain after video-assisted chest surgery. Sixty adults will be randomly assigned to one of the two blocks, and their pain levels will be checked over 24 hours. The goal is to find which method works better and cau…

This study looks at two ways to manage pain after hip replacement surgery. One method numbs the front of the hip joint, and the other adds numbing to the back. The goal is to see if using both together provides better pain relief. About 40 adults having hip replacement will take …

This study compares two ways to manage pain after ear tube surgery in 300 children aged 6 months to 6 years. One group gets standard pain medicine (fentanyl and ketorolac shots), and the other gets a nerve block (an injection near the ear). The goal is to see if the nerve block w…

This study looks at 50 adults having knee replacement surgery to find out which type of anesthesia works best for controlling pain and reducing the need for painkillers after the operation. Patients will receive either general anesthesia or spinal anesthesia, both combined with a…

This study tests if a surgeon can numb the knee during replacement surgery as effectively as an anesthesiologist using ultrasound. 48 adults having both knees replaced will get one method on each knee. The goal is to see if the surgeon's technique provides equal pain relief and r…

This study looks at whether adding a nerve block to the back of the hip to two standard front-hip blocks can improve pain relief after hip surgery. About 50 adults having hip surgery will be split into two groups to compare pain scores and the need for extra pain medicine in the …

This study tests if a magnesium drip given after a C-section can lower pain and help new mothers recover faster. About 150 women having planned or non-urgent C-sections will be randomly assigned to receive either magnesium or a saltwater placebo. Neither the patient nor the care …

This study looks at the best time to give a new pain drug called Anrikefon to adults having gallbladder surgery. About 274 people will either get the drug before anesthesia or right after the gallbladder is removed. The goal is to see which timing reduces pain better and helps pa…

This study tests if adding a common anti-inflammatory drug (dexamethasone) to a long-lasting numbing medicine (liposomal bupivacaine) can make pain relief last longer after shoulder surgery. About 80 adults having shoulder surgery with a nerve block will be randomly assigned to g…

This study will compare two types of nerve blocks to control pain after laparoscopic sleeve gastrectomy (weight-loss surgery). Sixty adults will be randomly assigned to receive either an intertransverse process block or a subcostal transversus abdominis plane block. The goal is t…

This study compares two types of nerve blocks to control pain after laparoscopic hysterectomy. Sixty women aged 18-65 will receive either an Intertransverse Process Block or an M-TAPA block. The main goal is to see which block provides better pain relief in the first 24 hours aft…

This study tests whether placing a loxoprofen sodium patch on the skin before video-assisted lung surgery can reduce pain and the need for strong painkillers afterward. About 156 adults aged 18 to 64 having lung surgery will be randomly assigned to get the patch or a placebo. The…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce pain and the need for strong painkillers after complex spinal surgery. About 98 adults having major back surgery will be randomly assigned to receive either the real stimulati…

This study tests an experimental pain medicine called CPL-01 in 112 adults who are having bunion surgery. Half will get the drug, half a placebo. Researchers will measure how much pain people feel and how much extra pain medicine they need. The goal is to see if CPL-01 provides b…

This study tests a new type of nerve block (r-PVB) to reduce pain and improve recovery after stoma closure surgery. 250 adults will receive either the new block or standard care. The goal is to see if the new method lowers pain scores and helps patients feel better faster.

This study tests whether a new type of nerve block, called SPSIPB, can reduce pain and the need for strong painkillers after heart surgery. About 120 adults having elective heart surgery will either receive this block or standard care. The goal is to see if the block leads to les…

This study compares two types of nerve blocks (ITPB and M-TAPA) to see which provides better pain relief after laparoscopic gallbladder removal. Sixty adults having elective surgery will be randomly assigned to receive one of the two blocks. Researchers will measure pain scores, …

This study tests whether injecting tramadol, with or without dexamethasone, into the knee after arthroscopy can reduce pain and the need for extra painkillers. About 135 adults having minor knee surgery will be randomly assigned to receive one of two drug combinations or a placeb…

This study tests two methods to reduce pain after keyhole stomach surgery for cancer. One method uses a standard ultrasound-guided nerve block, while the other applies a special temperature-sensitive gel mixed with numbing medicine directly to the surgical site. The goal is to se…

This study tests if using scalp nerve blocks and a drug called dexmedetomidine can reduce the need for strong opioid painkillers and prevent confusion after brain tumor surgery. About 2000 adults having brain surgery will be randomly assigned to receive one or both treatments, or…

This study compares two common root canal cleaning solutions—chlorhexidine and sodium hypochlorite (bleach)—to see which one leads to less pain the day after the procedure. About 90 adults needing a root canal will be randomly assigned to one of the two solutions. Participants wi…

This study looks at whether adding a steroid called dexamethasone to standard pain medicine helps people feel less pain after shoulder surgery. About 70 adults having shoulder arthroscopy will get either the steroid or a placebo, and researchers will measure how long it takes bef…

This study compares a new, simpler nerve block method to the traditional one for people having lung surgery with a camera (VATS). The goal is to see if the new method works just as well for pain control and helps patients recover faster. About 200 adults will be randomly assigned…

This study looks at whether a hot water foot bath can reduce pain and help people pass gas sooner after laparoscopic gallbladder removal. About 62 adults will be randomly assigned to receive the foot bath or standard care. The goal is to find a simple, drug-free way to improve re…

This study tests a technique called cryoablation, where doctors temporarily freeze nerves in the chest during open-heart surgery. The goal is to see if this reduces pain, helps patients breathe deeper and cough better after surgery, and lowers the need for strong painkillers like…

This study will compare two types of nerve blocks (ITP and ESP) to see which one provides better pain relief after robotic colorectal surgery. Fifty adults having this surgery will be randomly assigned to receive one of the two blocks. The main goal is to measure pain levels and …

This study looks at whether adding two types of nerve blocks (parasternal and adductor canal blocks) to standard pain medicine can better control pain and reduce the need for strong painkillers after coronary artery bypass surgery. About 120 adults having planned bypass surgery w…

This study looks at whether adding electroacupuncture to standard numbing medicine can lower pain and stress during impacted wisdom tooth extraction. Sixty adults aged 25-35 will be split into three groups: real electroacupuncture, fake acupuncture, or no extra treatment. Researc…

This study compares two common nerve block techniques for shoulder surgery pain. Sixty adults having arthroscopic shoulder surgery will receive either an interscalene block alone or a combined interscalene and suprascapular block. Researchers will measure pain scores, painkiller …

This study tests a special numbing injection called M-TAPA to see if it reduces pain and the need for strong painkillers after laparoscopic hysterectomy. About 60 adults having this surgery will be randomly assigned to get either the nerve block or standard pain care. Researchers…

This study tests whether a cold anti-inflammatory rinse (ketorolac tromethamine at 2-5°C) placed inside the tooth after root canal can lower post-treatment pain compared to the same rinse at room temperature. Sixty adults with painful tooth infections will rate their pain and hav…

This study compares two ultrasound-guided nerve blocks (TFP and ESP) to control pain after cesarean section. The goal is to see which block provides better pain relief and reduces the need for opioid painkillers. Sixty women having a planned C-section will participate, and their …

This study will compare two types of nerve blocks (SPSIP and ESP) to see which one works better for pain after rib fracture surgery. About 60 adults will take part, and researchers will measure pain levels, opioid use, and side effects. The goal is to find a safer, more effective…

This study compares two types of nerve blocks (M-TAPA and ESPB) to see which provides better pain relief after laparoscopic gallbladder removal. About 124 adults having elective surgery will receive one of the two blocks, and researchers will measure pain scores, opioid use, and …

This study looks at whether a device called TENS, which sends mild electrical pulses through the skin, can help reduce pain and improve sleep after inguinal hernia surgery. About 80 adults having this surgery will either receive TENS or standard care. Researchers will measure pai…

This study will look at 100 adults having gallbladder surgery to see if their anxiety before surgery and pain from getting an IV can predict how much pain they'll have afterward. Researchers hope to find simple ways to identify patients who might need extra pain relief. This is a…

This study looks at whether a skin monitor can reliably measure pain in newborns after surgery. Since babies can't tell us they're in pain, doctors currently use checklists and vital signs. The monitor tracks skin conductance, a sign of stress. Researchers will compare it to stan…

This study observes 100 adults undergoing total thyroidectomy to see if a cervical plexus block (a type of pain injection) is linked to better recovery and less swallowing pain. Researchers will compare those who received the block as part of routine care with those who did not. …

This study observes 440 patients receiving epidural catheters placed by anesthesia residents with at least two years of training. Researchers will compare two techniques—loss of resistance and hanging drop—to see which leads to more first-attempt successes and fewer complications…

This study looks at how a new pain medicine called Anrikefon works in older adults after laparoscopic belly surgery. Thirty people aged 65 and older will receive the drug and have their blood tested to measure drug levels. The goal is to understand how the drug behaves in older b…

This study looks at whether the position you are in when you get a nerve block for chest surgery changes how well it works. Researchers will compare sitting up versus lying on your side in 90 adults having video-assisted chest surgery. The goal is to see which position gives bett…

This study tests three different ways to numb the abdomen in healthy volunteers to see which works best. Each volunteer gets all three blocks on separate days, and researchers map the numb areas and check leg strength. The goal is to improve pain relief after surgery without usin…

This study watches 250 children aged 2 to 8 who are having urogenital surgery. Researchers want to see if the time they fast (no food or drink) before the operation changes how much pain or confusion they feel afterward. The goal is to learn if shorter fasting times could help ki…

This study looks at whether negative pressure wound therapy (a machine that helps heal wounds) is linked to ongoing pain six months after a war injury. Researchers will follow 150 adults with severe soft tissue injuries from blasts, bullets, or burns. The goal is to find early si…

This study will check if measuring belly muscle thickness with ultrasound before surgery can help predict how much opioid pain medicine older patients need after abdominal surgery. Researchers will follow 62 patients aged 65 and older for 24 hours after surgery, recording pain sc…