POSTOPERATIVE PAIN

This study tests two drugs, dexmedetomidine and tramadol, given before hemorrhoid surgery to see which one better reduces anxiety and pain. 90 adults will receive one of the drugs or a placebo. Researchers will measure anxiety levels and pain scores after surgery.

This study tests whether a nerve block called serratus intercostal plane block (SIPB) works better than the usual port infiltration for pain after laparoscopic gallbladder removal. 128 adults having this surgery will be randomly assigned to one of the two methods. The goal is to …

This study tests whether adding flurbiprofen axetil (an NSAID painkiller) to a standard local anesthetic injection in the scalp can better control pain after brain surgery. About 216 adults having brain surgery will receive either the combination or the anesthetic alone before th…

This study tests whether an Enhanced Recovery After Surgery (ERAS) protocol can reduce the need for strong painkillers after a kidney transplant from a living donor. Sixty adult participants will receive a carbohydrate drink, Tylenol, gabapentin, a local numbing injection, and ea…

This study compares two types of nerve blocks for pain after abdominal surgery with a midline cut. One is a modified thoracoabdominal block (M-TAPA) and the other is a standard rectus sheath block. Both use the same numbing medicine. The goal is to see which one provides better p…

This study tests whether a single injection of dexamethasone, a long-acting steroid, given 30 minutes before wisdom tooth removal can lessen post-surgery pain, facial swelling, and trouble opening the mouth. Sixty adults aged 18 to 35 are randomly assigned to receive either the s…

This study compares two types of nerve blocks—subcostal TAP block and rectus sheath block—to see which one better controls pain after a large abdominal incision (laparotomy). Sixty adult patients will receive one of the two blocks during surgery, and their pain scores and need fo…

This study planned to compare a less invasive version of open hemorrhoid surgery with the standard method to see if it causes less pain afterward. It was designed for adults with grade III hemorrhoids who needed surgery. The study was withdrawn before enrolling any participants, …

This study tests whether a numbing injection (bupivacaine) given after nose surgery can reduce the number of strong pain pills patients need. Fifty adults having primary septorhinoplasty will be randomly assigned to receive either the numbing shot or a placebo. Researchers will t…

This phase 4 trial compares giving no opioids versus a small prescription of 5 opioid tablets after inguinal hernia repair. About 904 adults having elective surgery will be randomly assigned to either group. The main goal is to see if the no-opioid group requests fewer refills wh…

This study compares two types of nerve blocks—quadratus lumborum block and retrolaminar block—for pain after lumbar disc surgery. About 84 adults having elective back surgery will receive one of the two blocks before surgery. Researchers will measure pain scores, opioid use, and …

This study tests whether a dexamethasone injection given right after wisdom tooth surgery can lower pain. Seventy adults are split into two groups: one gets standard numbing, the other gets an extra dexamethasone shot. Pain is tracked using a 0-10 scale at 24, 48, and 72 hours af…

This study tests two different injection spots for a nerve block in the thigh (adductor canal block) to see which provides better pain relief and reduces the risk of falls after total knee replacement. 68 adults having knee surgery under spinal anesthesia will be randomly assigne…

This study looks at two ways to manage pain after gynecological surgery: the EXORA block and epidural analgesia. Researchers will measure how well each method controls pain and how quickly patients recover their quality of life. The study involves 60 adults aged 18 to 80 who are …

This study tests whether adding two medications (dexamethasone and dexmedetomidine) to a standard nerve block can extend pain relief and reduce the need for opioid painkillers after shoulder, foot, or ankle surgery. About 100 adults will be randomly assigned to receive either the…

This study tests whether an automated pupillometer—a device that measures how the pupil reacts to light—can help doctors better assess and treat pain during and after surgery. 68 adults having abdominal surgery will be randomly assigned to either standard pain care or care guided…

This study looks at two types of ultrasound-guided nerve blocks (TAP and QLB) to manage pain after open inguinal hernia repair. 70 adults aged 18-65 will receive one of the blocks before surgery, and their pain levels and need for extra painkillers will be tracked for 24 hours. T…

This study tests whether an ultrasound-guided nerve block (superficial cervical plexus block) given before neck surgery can lower pain after the operation and reduce the need for opioid painkillers. Sixty adults aged 18-60 having elective neck surgery under general anesthesia wil…

This study looks at two different nerve blocks—pericapsular nerve block and anterior quadratus lumborum block—to see which one works better for reducing pain when patients are positioned for spinal anesthesia and after hip fracture surgery. About 64 adults aged 30 to 85 will take…

This study aimed to see if injecting a long-lasting painkiller (Exparel) into the vaginal cuff before a minimally invasive hysterectomy could lower pain after surgery. It planned to compare the painkiller mixed with a standard numbing drug versus the standard drug alone. The stud…

This study looks at whether a special nerve block (serratus posterior superior intercostal plane block) can reduce pain and the need for painkillers after cervical disc herniation surgery. About 40 adults having this neck surgery will be divided into groups to compare the nerve b…

This study looks at whether a special nerve block (called ESPB) can help control pain after surgery for a slipped disc in the lower back. About 78 adults having this surgery will receive the block, and researchers will measure their pain levels, how much pain medicine they need, …

This study aimed to see if taking oral steroids after nose surgery (rhinoplasty) could reduce pain, nausea, swelling, and bruising. It was designed for adults having their first nose surgery, but the study was withdrawn before any participants were enrolled. No results are availa…

This study compares two types of nerve blocks (serratus plane block and rhomboid intercostal plane block) to see which provides better pain relief after breast reduction surgery. About 90 women will receive one of the blocks before surgery, and their pain and opioid use will be t…

This study tests two ways to numb the area for collarbone surgery. One method (SCB-CPB) aims to provide good pain relief with fewer breathing side effects than the standard technique (SCB-ISB). 34 adults having collarbone surgery will be randomly assigned to one of the two nerve …

This study looks at whether showing children a video before their tonsil surgery can reduce their fear, anxiety, and pain. 60 children aged 4-10 who are having their first surgery will watch an educational video. Their fear, anxiety, and pain levels will be measured before and af…

This study tests whether a specific nerve block (erector spinae plane block) can lower the need for strong painkillers after open abdominal surgery. About 46 adults having abdominal surgery under general anesthesia will receive the block or standard care. The goal is to see if fe…

This study compares two types of nerve blocks to manage pain after arthroscopic shoulder surgery. The goal is to find which block provides better pain relief while reducing the risk of temporary diaphragm paralysis, a common side effect. Thirty adults having shoulder surgery will…

This study follows 300 adults who receive light therapy before and after plastic surgery as part of their routine care. Researchers will track pain, swelling, bruising, and patient satisfaction over time. The goal is to describe recovery outcomes, not to compare treatments.

This study looks at whether certain signs of inflammation in the blood can predict if numbing shots for dental work will work well and how much pain people feel afterward. About 150 adults with tooth pain will have their blood tested and their anesthesia success tracked. The goal…

This study looks at how the opioid remifentanil affects a person's pain threshold before surgery. About 40 adults will have their pain threshold measured using a pressure device while receiving increasing doses of the drug. The goal is to better understand how to manage pain duri…

This study looks at whether a child's genes can predict how they will respond to morphine after tonsil surgery. The goal is to find out which children are likely to have severe side effects or poor pain relief. 1,200 children aged 3-15 are being studied to help doctors personaliz…