New scalp injection could cut opioid use after brain surgery
NCT ID NCT05624359
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 37 times
Summary
This study tests whether adding flurbiprofen axetil (an NSAID painkiller) to a standard local anesthetic injection in the scalp can better control pain after brain surgery. About 216 adults having brain surgery will receive either the combination or the anesthetic alone before their operation. The main goal is to see if the combination reduces the amount of strong painkiller (sufentanil) needed in the 48 hours after surgery.
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Beijing Tiantan Hospital
Beijing, China
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
flurbiprofen axetil (an NSAID painkiller) combined with ropivacaine (a local anesthetic)
What this could lead to
If it works, this could offer a better way to control pain after brain surgery, reducing the need for strong opioid painkillers.
What could go wrong
This is a small, early-stage trial that is currently suspended. The added benefit of flurbiprofen may be small, and there is a risk of side effects like bleeding or allergic reactions.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.