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Scientists probe whether ear-zap device triggers body's own opioids

NCT ID NCT05490134

First seen Jan 09, 2026 · Last updated Jun 19, 2026 · Updated 22 times

Summary

This study looks at how a device that gently stimulates nerves in the ear might relieve pain. Researchers want to know if it works by making the body release its own natural painkillers (opioids). They will test this in 136 healthy adults by giving some a drug that blocks opioids and seeing if the pain relief goes away. The goal is to understand the mechanism, not to treat a disease.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Medical University of South Carolina

    RECRUITING

    Charleston, South Carolina, 29425, United States

    Contact Email: •••••@•••••

Conditions

The condition(s) this trial relates to.

agnosia pain agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.