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New study aims to tame sedation risks for Life-Support patients

NCT ID NCT07032987

Knowledge-focused Sponsor: Guy's and St Thomas' NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how painkillers and sedatives are given to patients on ECMO, a life-support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals, then work with patients, families, and staff to design a safer sedation protocol. The goal is to reduce complications like confusion, memory problems, and long hospital stays.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a standard sedation protocol for ECMO patients, potentially reducing long-term health problems like anxiety and memory issues.
What could go wrong
This is an early-stage observational and protocol-development study, not testing a treatment. The protocol may not improve outcomes or may be difficult to implement across different hospitals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Stage 1: mechanically ventilated adult ICU patients Stage 2: Healthcare professionals (doctors, nurses and pharmacists) with experience caring for ECMO patients. ECMO survivors who have recovered and discharged from hospital, and their family.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Stage 1 (multi-centre observational study): Inclusion Criteria: 1. Aged 18 years and older. 2. Receiving continuous IV infusions of analgosedation (opioids, benzodiazepines, and/or propofol). 3. Receiving ECMO for moderate to severe respiratory failure (PaO2/FiO2 (P/F) ratio \<20 kilopascals (kPa)) for ≤ 7 days during the week of recruitment. 4. Non-ECMO ICU patients (control group): must satisfy inclusion criteria 1 and 2, and have received mechanical ventilation for moderate to severe respiratory failure (P/F ratio \< 20kPa) for at least 48 hours OR mechanical ventilation for cardiovascular disorder (out of hospital cardiac arrest, following cardiothoracic or transplant surgery or percutaneous coronary intervention or acute heart failure). Exclusion Criteria: 1. Anticipated length of ICU stay in recruiting centre for less than 24 hours. 2. Withdrawal of life-sustaining treatment in the next 24 hours. Stage 2 (mixed methods study): Inclusion Criteria: 1. Healthcare professionals working at one of two ECMO centres (St Thomas' Hospital and Royal Brompton Hospital (part of Guy's and St Thomas' NHS Foundation Trust). 2. ECMO survivors (patients admitted to ICU and survived ECMO organ support) who have returned home, and recovered. 3. Family members of ECMO survivors, whose relative is no longer hospitalised. Exclusion Criteria: 1. ECMO survivors currently receiving treatment in hospital. 2. ECMO survivors with severe cognitive issues (issues with short-term memory and thinking). 3. ECMO survivors who cannot communicate in English. 4. Non-ECMO survivors and family members.

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Conditions

The condition(s) this trial relates to.

adult acute respiratory distress syndrome agnosia cardiogenic shock pain agnosia respiratory distress syndrome in premature infants respiratory failure Shock, Cardiogenic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Analgesia Cardiogenic shock Extracorporeal membrane oxygenation (ECMO) Intensive care medicine Opioid analgesia Respiratory distress syndrome (RDS) Sedation and analgesia Sedation for mechanical ventilation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Guy's and St Thomas' NHS Foundation Trust

    RECRUITING

    London, London, SE1 7EH, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.