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New combo could cut morphine use after hip surgery

NCT ID NCT06577155

Symptom relief Sponsor: Asklepieion Voulas General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding nalbuphine to the standard spinal anesthetic levobupivacaine helps control pain after total hip replacement. Sixty adults were split into two groups: one received levobupivacaine alone, the other received levobupivacaine plus nalbuphine. Researchers measured how much morphine patients needed in the first 24 hours, along with pain scores and side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nalbuphine
What this could lead to
If it works, this could offer better pain relief and less need for morphine after hip replacement surgery.
What could go wrong
This is a small, early-phase study with only 60 patients, so results may not apply to everyone. Adding nalbuphine may also cause side effects like dizziness or nausea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

60 people

The number who actually took part.

Started

Aug 2024

Finished

Jan 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Physical status according to American Society of Anesthesiologists (ASA) I-III * Patients scheduled for total hip arthroplasty Exclusion Criteria: * BMI above 40 * Serious psychiatric, mental and cognitive disorders * Contraindication for central and/or peripheral nervous blockade * History of allergic or other adverse reactions on the agents used in the study * Chronic opioid

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Conditions

The condition(s) this trial relates to.

agnosia pain agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Analgesia Total hip arthroplasty

Contacts and locations

Locations

  • Asklepieion Hospital of Voula

    Athens, Ελλάδα (+30), 16675, Greece

More trials for these conditions

Other studies related to the condition(s) this trial covers.