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Can dexmedetomidine or lidocaine replace opioids for gallbladder surgery pain?

NCT ID NCT05788393

Symptom relief Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed trial tested whether giving dexmedetomidine or lidocaine continuously during gallbladder surgery can control pain afterward and reduce the need for opioids. 64 adults undergoing laparoscopic cholecystectomy were randomly assigned to receive one of the two drugs. The main goal was to measure pain scores using a 0-10 scale after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine and lidocaine
What this could lead to
If successful, this could show that either drug effectively controls pain after gallbladder surgery while reducing the need for opioids.
What could go wrong
This is a small, completed Phase 4 trial with only 64 participants, so results may not apply to everyone. The study compares two drugs but does not test a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

64 people

The number who actually took part.

Started

Apr 2024

Finished

Feb 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient's status ASA status-I and II. * Patients age above 18 years old. * Patients scheduled for laparoscopic cholecystectomy. Exclusion Criteria: * Patient refusal. * Patients with known allergy to dexmedetomidine or lidocaine. * Patients with significant hepatic dysfunction. * Patients with severe renal disease. * Patients with chronic pain. * Regular use analgesics, antidepressants or opioids in last month. * Any known convulsive disorder. * Significant heart disease. * Morbid obesity (BMI\>35). * Patients with autoimmune disease * Patients on corticosteroid therapy * Pregnancy * Breast feeding * Woman under hormonal treatment

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Conditions

The condition(s) this trial relates to.

agnosia pain agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Analgesia

Contacts and locations

Locations

  • Assiut university hospitals

    Asyut, Asyut Governorate, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.