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Brain's pain 'Off Switch' may predict who gets relief from back injections

NCT ID NCT05961800

Knowledge-focused Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 28, 2026 · Updated 3 times

Summary

This study looks at how the brain naturally reduces pain signals and whether that ability affects how well a lumbar medial branch block (a common injection for back pain) works. Researchers will test 40 adults with chronic low back pain using heat, pressure, and other sensations before and after the injection. The goal is to understand why some people get more relief than others.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors predict which patients will benefit most from nerve block injections for back pain.
What could go wrong
This is a small, early observational study with only 40 participants. It does not test a new treatment, so results may not change practice directly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2023

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Scheduled for lumbar MBB in UPMC Pain Management clinics * Age \> 18 years old * Predominantly axial chronic low back pain at least 3 months on a daily basis * Must meet the minimum criteria for cognitive function using the PROMIS 2-item cognitive screener (\>3) * Low back pain intensity of \> 3/10 * Willing and able to receive study-related phone calls Exclusion Criteria: * History of spine surgery at the level of the lumbar MBB * Active worker's compensation or litigation claims * New pain and/or psychiatric treatments within 2 weeks of enrollment * Not fluent in English and/or not able to complete the questionnaires * Any clinically unstable systemic illness that is judged to interfere with the study

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Conditions

The condition(s) this trial relates to.

agnosia Chronic Pain chronic pain syndrome pain agnosia Pain, Procedural

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Analgesia Facet joint pain Pain, chronic Pain, procedural

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UPMC St. Margaret

    RECRUITING

    Pittsburgh, Pennsylvania, 15215, United States

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