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Scientists probe nerve signals to unlock Stiff-Knee gait mystery

NCT ID NCT04947865

Knowledge-focused Sponsor: MetroHealth Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 1 time

Summary

This study looks at how nerve reflexes in the thigh muscle affect walking in people who have had a stroke and have a stiff-knee gait. Researchers will use mild electrical stimulation to measure reflex activity while participants walk. The goal is to better understand why some stroke survivors have trouble bending their knee during walking.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

54 people

The number who actually took part.

Started

Jun 2021

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Aged at least 18 * Premorbidly independent * If post-stroke, mild to moderate impairment determined by standard practices per the physical therapist * Able to continuously walk for 30 minutes * If post-stroke, reduced knee flexion during walking relative to unimpaired side * If post-stroke, hemiparesis * Ability to provide informed consent Exclusion criteria: * No history of serious lower limb musculoskeletal injury * No functionally relevant osteoarthritis and weight-bearing restrictions * No functionally relevant polyneuropathy * No functionally relevant cognitive impairment * No functionally relevant vision impairment

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Conditions

The condition(s) this trial relates to.

Gait Disorders, Neurologic Mobility Limitation stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic stroke Gait disorder, sensorimotor Gait disorders, neurologic Gait, hemiplegic Gait, spastic Stroke Walking, difficulty

Contacts and locations

Locations

  • MetroHealth Medical Center

    Cleveland, Ohio, 44109, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.