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Ear stimulation may guide tailored stroke recovery

NCT ID NCT06335199

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 15, 2026 · Updated 2 times

Summary

This study looked at how stimulating a nerve in the ear (tVNS) affects pupil size in stroke survivors and healthy adults. Researchers compared stimulation on one side versus both sides to see which causes a bigger pupil response. The goal is to use pupil changes as a guide for personalizing stroke rehabilitation. The study involved 21 participants and measured pupil size during stimulation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcutaneous vagus nerve stimulation (tVNS)
What this could lead to
If successful, this could help personalize stroke rehabilitation by identifying which stimulation method works best for each patient.
What could go wrong
This is a small, early-stage study with only 21 participants, focused on measuring pupil response rather than clinical outcomes. Results may not translate to better recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

21 people

The number who actually took part.

Started

Nov 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 89 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18-89 years old across all races, genders, and ethnicities. * Post-stroke subjects will have persistent hemiparesis on the upper extremity (UE) with some residual UE voluntary movement. Exclusion Criteria: Able-bodied subjects: * Younger than 18 years old or older than 89 years old * Current or history of cardiac disease * Have a vision problem not corrected by glasses or contact lenses * Have an implanted device such as a neurostimulator or cochlear implant * Current or history of tympanic membrane perforation * Had a stroke or lesion (including tumor) in your brain * Had a head injury or brain surgery * Suffer from frequent or severe headaches * Had a fainting spell or syncope * Have any metal in the head such as shrapnel, surgical clips, or fragments from welding or metal work * Have any implanted device such as cardiac pacemakers, medical pumps, or intra-cardiac lines * Had any brain-related conditions (i.e. multiple sclerosis, Parkinson, Alzheimer) * Had any illness that caused brain injury (i.e. meningitis, aneurysm, brain tumor) * Had any head trauma that was associated with a loss of consciousness or diagnosed as a concussion * Being treated for any psychiatric condition (i.e. depression, anxiety, PTSD, schizophrenia) * Suspected of pregnancy Post-stroke subjects: * Younger than 18 years old or older than 89 years old * Current or history of cardiac disease * Have a vision problem not corrected by glasses or contact lenses * Have any implanted devices such as a neurostimulator or cochlear implant * Current or history of tympanic membrane perforation * No persistent hemiparesis on the upper extremity (UE) * No residual UE voluntary movement * A first stroke less than 4 months prior to the participation * Serious uncontrolled medical conditions * Excessive pain in any joint of the more affected extremity * Unable to stand independently for 2 min., transfer independently to and from the toilet or perform sit-to-stand * Suffer from frequent or severe headaches * Had a fainting spell or syncope * Have any metal in the head such as shrapnel, surgical clips, or fragments from welding or metal work * Have any implanted device such as cardiac pacemakers, medical pumps, or intra-cardiac lines * Had any illness that caused brain injury (i.e. meningitis, aneurysm, brain tumor) * Had any head trauma that was associated with a loss of consciousness or diagnosed as a concussion * Being treated for any psychiatric condition (i.e. depression, anxiety, PTSD, schizophrenia) * Suspected of pregnancy * A score of less than 24 on the Folstein Mini-Mental State Examination * Excessive frailty or lack of stamina (e.g., cannot attend to instructions, stay awake, engage in functional activities, etc.) * Excessive pain in any joint of the more affected extremity that could limit ability to cooperate with the intervention

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Human Neuromuscular Physiology Lab

    Atlanta, Georgia, 30318, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.