Ear stimulation may guide tailored stroke recovery
NCT ID NCT06335199
First seen Jun 27, 2026 · Last updated Sep 15, 2026 · Updated 2 times
Summary
This study looked at how stimulating a nerve in the ear (tVNS) affects pupil size in stroke survivors and healthy adults. Researchers compared stimulation on one side versus both sides to see which causes a bigger pupil response. The goal is to use pupil changes as a guide for personalizing stroke rehabilitation. The study involved 21 participants and measured pupil size during stimulation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- transcutaneous vagus nerve stimulation (tVNS)
- What this could lead to
- If successful, this could help personalize stroke rehabilitation by identifying which stimulation method works best for each patient.
- What could go wrong
- This is a small, early-stage study with only 21 participants, focused on measuring pupil response rather than clinical outcomes. Results may not translate to better recovery.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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21 people
The number who actually took part.
- Started
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Nov 2024
- Finished
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Oct 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 89 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 18-89 years old across all races, genders, and ethnicities. * Post-stroke subjects will have persistent hemiparesis on the upper extremity (UE) with some residual UE voluntary movement. Exclusion Criteria: Able-bodied subjects: * Younger than 18 years old or older than 89 years old * Current or history of cardiac disease * Have a vision problem not corrected by glasses or contact lenses * Have an implanted device such as a neurostimulator or cochlear implant * Current or history of tympanic membrane perforation * Had a stroke or lesion (including tumor) in your brain * Had a head injury or brain surgery * Suffer from frequent or severe headaches * Had a fainting spell or syncope * Have any metal in the head such as shrapnel, surgical clips, or fragments from welding or metal work * Have any implanted device such as cardiac pacemakers, medical pumps, or intra-cardiac lines * Had any brain-related conditions (i.e. multiple sclerosis, Parkinson, Alzheimer) * Had any illness that caused brain injury (i.e. meningitis, aneurysm, brain tumor) * Had any head trauma that was associated with a loss of consciousness or diagnosed as a concussion * Being treated for any psychiatric condition (i.e. depression, anxiety, PTSD, schizophrenia) * Suspected of pregnancy Post-stroke subjects: * Younger than 18 years old or older than 89 years old * Current or history of cardiac disease * Have a vision problem not corrected by glasses or contact lenses * Have any implanted devices such as a neurostimulator or cochlear implant * Current or history of tympanic membrane perforation * No persistent hemiparesis on the upper extremity (UE) * No residual UE voluntary movement * A first stroke less than 4 months prior to the participation * Serious uncontrolled medical conditions * Excessive pain in any joint of the more affected extremity * Unable to stand independently for 2 min., transfer independently to and from the toilet or perform sit-to-stand * Suffer from frequent or severe headaches * Had a fainting spell or syncope * Have any metal in the head such as shrapnel, surgical clips, or fragments from welding or metal work * Have any implanted device such as cardiac pacemakers, medical pumps, or intra-cardiac lines * Had any illness that caused brain injury (i.e. meningitis, aneurysm, brain tumor) * Had any head trauma that was associated with a loss of consciousness or diagnosed as a concussion * Being treated for any psychiatric condition (i.e. depression, anxiety, PTSD, schizophrenia) * Suspected of pregnancy * A score of less than 24 on the Folstein Mini-Mental State Examination * Excessive frailty or lack of stamina (e.g., cannot attend to instructions, stay awake, engage in functional activities, etc.) * Excessive pain in any joint of the more affected extremity that could limit ability to cooperate with the intervention
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Human Neuromuscular Physiology Lab
Atlanta, Georgia, 30318, United States
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