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Can blood markers predict brain injury outcomes?

NCT ID NCT04951453

Knowledge-focused Sponsor: Rigshospitalet, Denmark Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This study looks at people with acute brain injuries from trauma, bleeding, or aneurysm. Researchers will measure blood markers of oxidative and nitrosative stress—chemical imbalances that may harm brain cells—during the early phase after injury. They will track how these markers relate to neurological recovery, complications, and survival over six months. The goal is to better understand the body's stress response and its link to outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify early markers that predict recovery or complications after brain injury, guiding future treatments.
What could go wrong
This is an observational study, so it won't test a treatment. The findings may not directly change care, and the results could be inconclusive.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

150 people

The number who actually took part.

Started

Aug 2021

Finished

Apr 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with acute brain injury (SAH, ICH or TBI) admitted to the NICU at Rigshospitalet - see detailed inclusion and exclusion criteria above.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Admission to the Neurointensive Care Unit (NICU) at Rigshospitalet * Diagnosis of TBI, spontaneous ICH or aneurysmal SAH * Initiation of blood sampling possible within 3 days after ictus * Expected length of stay in the NICU and/or intermediate care unit of ≥48 hours * Closest relatives understand written and spoken Danish Exclusion Criteria: * Brain death before inclusion * Expected death within 24 hours * ICH secondary to other causes (e.g., a tumour or arteriovenous malformation) * SAH secondary to other causes (e.g., a mycotic aneurysm or arteriovenous malformation)

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Conditions

The condition(s) this trial relates to.

acquired aneurysmal subarachnoid hemorrhage Brain Injuries, Traumatic brain injury intracerebral hemorrhage subarachnoid hemorrhage traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Intracerebral hemorrhage Subarachnoid hemorrhage, aneurysmal Traumatic brain injury

Contacts and locations

Locations

  • Rigshospitalet

    Copenhagen, DK-2100, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.