Rigshospitalet, Denmark

This study looks at whether people with severe nasal polyps who have been symptom-free for at least a year on biologic drugs (Nucala or Dupixent) can stop taking them and still stay well. Sixty-six participants will either stop their medication or continue it, and researchers wil…

This study tests whether a prehabilitation program (exercise and nutrition support) before a stem cell transplant can improve quality of life and physical recovery in adults with blood cancer. About 110 participants will be randomly assigned to the program or standard care. The g…

This study looks at whether people with chronic sinusitis and nasal polyps can safely take their biologic medication (like dupilumab or mepolizumab) less often without losing symptom control. About 135 adults who have been stable on the standard 4-week schedule will be followed t…

This study tests whether a daily tablet of semaglutide (Rybelsus) can safely control high blood sugar in people who recently had a kidney transplant. About 104 participants will receive either the drug or a placebo for 14 weeks, alongside standard care. The goal is to see if the …

This study tests if replacing an infected heart device right away is as safe and effective as waiting for a later procedure. About 176 adults with heart device infections will be randomly assigned to immediate or delayed reimplantation. The goal is to see if immediate replacement…

This study tests whether a technique called ischemic postconditioning, done during emergency artery-opening treatment, can reduce heart muscle damage and improve outcomes for people having a severe heart attack (STEMI). About 1,800 participants will be randomly assigned to receiv…

This study compares two approaches for people with severe aortic stenosis who go into cardiogenic shock (the heart can't pump enough blood). One group gets a new heart valve within 12 hours; the other gets standard ICU care and the valve later. The goal is to see if immediate tre…

This study compares an automated insulin delivery system (CamAPS FX) to standard insulin therapy in 305 women with type 1 diabetes who are planning pregnancy or are in early pregnancy. The goal is to see if the automated system helps keep blood sugar in a healthy range and improv…

This study aims to improve treatment for men with high-risk prostate cancer by testing two changes to standard radiotherapy: giving a higher dose directly to the tumor (a focal boost) and reducing the number of treatment sessions from 20 to 12. About 1,016 participants will be ra…

This study tests whether a special 3D ultrasound can accurately measure how deep a skin cancer (squamous cell carcinoma) goes after it's removed. About 30 adults will have their tumor scanned with 3D ultrasound after surgery, and the results will be compared to standard lab tests…

This study compares two ways to diagnose a peritonsillar abscess (a pus pocket near the tonsils): the usual exam (looking and feeling) versus adding a small ultrasound probe inside the mouth. About 368 adults with suspected abscess will take part. The goal is to see if ultrasound…

This study tests whether a high dose of the steroid dexamethasone can reduce pain when coughing the morning after lung surgery. It includes 80 adults with lung cancer who are expected to have high pain levels. Patients receive either a high or low dose of the drug during surgery,…

This study tests whether a personalized exercise program can help adults with post-concussion syndrome—a condition where symptoms like headache, dizziness, and fatigue last for weeks or longer after a mild head injury. Researchers will measure how long participants can exercise w…

This study tests whether injecting a form of Botox around nerves in the lower legs can safely reduce pain in people with diabetic neuropathy. Eighty adults with diabetes and chronic, symmetrical foot pain will receive either the Botox or a placebo every 12 weeks for 24 weeks. Res…

This study tests whether a drug that widens blood vessels (nitrates) works better than a standard water pill (furosemide), or if using both together is best, for people with sudden fluid buildup in the lungs from heart failure. About 1,100 adults with severe shortness of breath a…

This study tests whether a virtual reality (VR) program can help adults with long-term non-cancer pain avoid worsening pain. About 44 participants will either use the VR self-management program or continue with their usual care. The goal is to see if VR can reduce pain intensity …

This study looks at whether 18 weeks of guided exercise can help people with metastatic colorectal cancer feel better during chemotherapy. About 150 adults starting their first round of chemo will either join an exercise program or continue usual care. The goal is to see if exerc…

This study looks at whether a personalized strength exercise program can improve muscle function and reduce attacks in adults with hypokalemic or hyperkalemic periodic paralysis. Participants will be tested at the start, after 12 weeks, and after 24 weeks, with supervised trainin…

This study tests whether telepresence robots can help children aged 5-17 with cancer attend school remotely when they can't be there in person. The robots let kids see, hear, and move around their classroom from home or the hospital. Researchers will measure if this improves scho…

This study tests a new way to deliver radiation for head and neck cancer that adjusts daily to changes in the patient's anatomy. The goal is to lower radiation to healthy organs and reduce side effects like trouble swallowing and dry mouth. About 40 adults with throat or voice-bo…

This study looks at whether measuring CRP levels (a marker of inflammation) and giving patients an information leaflet can help doctors prescribe fewer antibiotics for respiratory infections. About 1050 adults in Kyrgyzstan will take part. The goal is to see if these tools safely…

This study looks at two conditions that cause sudden vision loss: giant cell arteritis (GCA) and NAION. GCA is a blood vessel inflammation that needs quick treatment, while NAION does not benefit from that treatment. Researchers will use advanced PET/MRI and eye scans to find sig…

This study looks at men over 65 who have chest pain but no blocked arteries. Researchers want to find out how many of them have a hidden heart condition called cardiac amyloidosis. Participants will have blood tests, heart scans, and other exams. No treatment is given—this is onl…

This study tests a personalized rehabilitation program for people who survived a sudden cardiac arrest outside the hospital. The goal is to help them return to work within 12 months. 214 participants will either receive the special rehab plus usual care, or usual care alone. The …

This study aims to understand why up to 20% of people still have moderate to severe pain after hip or knee replacement surgery. Researchers will invite 100 patients who have persistent pain to complete questionnaires about different types of pain. The goal is to better classify t…

This study tracks how much physical movement (like sitting up or moving limbs) is given to adults with severe brain injury in Scandinavian intensive care units. Researchers will monitor 198 patients to see how the amount and intensity of movement relates to safety and recovery. T…

This study looks at the tiny blood vessels inside thyroid nodules using a special ultrasound technique. Researchers hope to find patterns that help tell harmless nodules from those that need surgery. About 50 people with thyroid nodules and healthy volunteers will take part. The …

This study looks at why people with Waldenström's macroglobulinemia (a rare blood cancer) often develop nerve damage, causing pain, numbness, and trouble moving. Researchers will screen 90 patients to find how common this nerve damage is and what causes it. The goal is to speed u…

This study watches 148 adults with acute brain injury who have a drainage tube in their head. Researchers want to see if changes in a natural chemical called lactate in the brain fluid can signal an infection early. The goal is to find better ways to detect and manage these serio…

This study explores whether a wireless chest patch that tracks heart rate, breathing, oxygen, blood pressure, and temperature is practical and well-liked by nurses and patients after major spinal surgery. About 150 adults having spinal deformity surgery will wear the sensor along…

This study looks at what happens to appetite and food choices when physically active men aged 40 to 55 suddenly stop exercising for two weeks. Participants are randomly assigned to either keep their normal routine or drastically cut back activity (under 1,500 steps a day). Resear…

This study looks at how blood flow and sugar use in the brain are different in people with Alzheimer's disease, especially those who also have type 2 diabetes. Researchers will use special PET scans to measure these changes without needles. The goal is to find early signs of dise…

This study is collecting information from 500 people with lymphatic disorders (often linked to heart disease) across Europe. Researchers want to see how well current tests and treatments, like lymphatic embolization, work in real life. The goal is to find the best ways to diagnos…

This study looks at how well patients understand the information they get before major abdominal cancer surgery, what they expect, and if they later regret their decision. Researchers will follow 90 adults having surgery for pancreatic, liver, stomach, or bowel cancer at a Danish…

This study watches 100 adults with blood cancers like lymphoma who are getting CAR T-cell or bispecific antibody therapy. Researchers track vital signs and immune markers to find early clues that a serious complication called cytokine release syndrome (CRS) may be developing. The…

This study looks at how showing AI predictions to doctors affects their confidence and accuracy in predicting preterm birth. About 125 doctors will review cases with ultrasound images and see AI results in different formats. The goal is to find which AI presentation helps doctors…

This study follows 1,000 children under 18 who have surgery for a brain tumor in the back part of the brain. It aims to understand why up to 1 in 4 develop Cerebellar Mutism Syndrome, a condition where they lose the ability to speak. Researchers will look at surgical techniques, …

This study looks at how two natural gut hormones, GIP and GLP-1, affect how the body takes up sugar and moves blood through organs. Researchers will use a special full-body PET scanner to measure these effects in healthy volunteers and people with type 2 diabetes. The goal is to …

This study looks back at the last 10 years to understand how many people in Denmark use a breathing machine at home through a tube in their throat. Researchers will examine which diseases lead to this need and how many patients survive one year after starting. The goal is to gath…

This study aims to see if an online screening tool can help find mental health problems in children aged 5-17 who were born with heart defects. Researchers will test the screening in 4800 Danish kids and create a website to help families and doctors better understand and address …