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Beetroot juice may boost heart blood flow and walking in leg artery disease

NCT ID NCT02553733

Disease control Sponsor: David N. Proctor, PhD Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether short-term consumption of concentrated beetroot juice, which is rich in inorganic nitrate, can improve blood flow to the heart and legs, and enhance walking performance in people with peripheral arterial disease (PAD). PAD causes leg pain during exercise due to reduced blood flow. Participants will consume either beetroot juice or a placebo that looks and tastes the same but has the nitrate removed. The study measures how long they can walk on a treadmill and changes in coronary blood flow during leg exercise.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
beetroot juice (dietary nitrate)
What this could lead to
If effective, beetroot juice could become a simple dietary supplement to help people with peripheral arterial disease walk farther with less leg pain.
What could go wrong
This is a small early-stage trial, so results may not apply widely. Beetroot juice can cause harmless red urine or stool, and people on certain heart medications should avoid it.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

11 people

The number who actually took part.

Started

Dec 2015

Finished

Feb 2020

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients with peripheral arterial disease (PAD) 2. Capable of giving informed consent 3. Men and women age 21- 85 years 4. Diagnosed with PAD (i.e., ankle-brachial index below 0.9) 5. Fontaine stage II or less - no pain while resting 6. Satisfactory history and physical exam Exclusion Criteria: 1. Children 2. Pregnant or nursing women 3. Patients taking nitroglycerine or nitrate preparations 4. Patients taking phosphodiesterase inhibitors such as sildenafil or tadalafil 5. Patients taking proton pump inhibitors 6. Ejection fraction \< 40% 7. Uncontrolled hypertension 8. Uncontrolled diabetes 9. Myocardial infarction within past 6 months or unstable angina 10. Severe lung disease (i.e., on supplemental oxygen or frequently use rescue inhalers) 11. Abnormality in hemoglobin or hematocrit or methemoglobin 12. Impaired renal function 13. Impaired liver function 14. History or diagnosis of Barrett's esophagus 15. Known allergy to beetroot juice or lemon juice 16. Inability to walk on a treadmill at a moderate pace (2.0 miles/hour)

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Conditions

The condition(s) this trial relates to.

peripheral arterial disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Peripheral arterial disease

Contacts and locations

Locations

  • Milton S. Hershey Medical Center

    Hershey, Pennsylvania, 17033, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.