Spinal fluid clues may reveal brain recovery secrets
NCT ID NCT07600996
First seen Jun 27, 2026 · Last updated Sep 10, 2026 · Updated 2 times
Summary
This study is observing tiny energy-producing parts of cells, called mitochondria, in the spinal fluid of people who have had a stroke or have Alzheimer's disease. Researchers want to see if these markers relate to how well patients recover after a stroke. The study does not give any treatment—it only uses leftover fluid from routine medical tests.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help identify new ways to measure brain damage or recovery after stroke and Alzheimer's disease.
- What could go wrong
- This is a small, early observational study with only 40 participants. It does not test any treatment, so results may not lead to immediate changes in care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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40 people
The number who actually took part.
- Started
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Mar 2026
- Finished
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Aug 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population will include adult patients treated at Xuanwu Hospital, Capital Medical University between March 2026 and May 2026 who are diagnosed with ischemic stroke or Alzheimer disease and require diagnostic lumbar puncture for clinical indications. Only patients with available residual cerebrospinal fluid after completion of routine clinical testing will be included.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 18 years or older. Patients treated at Xuanwu Hospital, Capital Medical University between March 2026 and May 2026. Diagnosis of ischemic stroke or Alzheimer disease according to standard clinical diagnostic criteria. Diagnostic lumbar puncture performed for clinical indications as part of routine medical care. Availability of residual cerebrospinal fluid after completion of clinically required testing. Ability to provide written informed consent, or availability of a legally authorized representative to provide consent when appropriate. For ischemic stroke patients, availability of baseline neurological assessment and planned follow-up for 90-day modified Rankin Scale assessment. Exclusion Criteria: * Lumbar puncture performed solely for research purposes rather than clinical indication. Insufficient residual cerebrospinal fluid volume for research flow cytometry analysis. Grossly bloody or severely contaminated cerebrospinal fluid sample that precludes reliable flow cytometry analysis. Known central nervous system infection, malignant meningitis, or other inflammatory or neoplastic condition that, in the investigator's judgment, may substantially confound cerebrospinal fluid mitochondrial measurements. Inability to obtain informed consent from the participant or legally authorized representative. Missing key clinical outcome data, including admission NIHSS, discharge NIHSS, or planned 90-day mRS follow-up for ischemic stroke participants. Any condition judged by the investigator to make the participant unsuitable for inclusion in the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Xuanwu Hospital
Beijing, None Selected, 100053, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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