Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1

This trial tests whether a Mediterranean diet, enriched with extra virgin olive oil or walnuts, can lower the chance of stroke and slow cognitive decline in people with cerebral amyloid angiopathy (CAA) or CADASIL, two conditions that affect blood vessels in the brain. Participan…

This study investigates whether changes in retinal blood vessels can serve as a marker for cerebral small vessel disease (SVD), a common condition in older adults that increases stroke and dementia risk. The trial includes people with SVD-related conditions like CADASIL, sporadic…

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This study follows 155 adults with CADASIL, a genetic condition that narrows small blood vessels and raises the risk of strokes and dementia, over nine years. Researchers will use brain scans, blood tests, and other exams to track how the disease changes blood vessels and thinkin…

This study looks at 100 adults with CADASIL, a genetic condition that affects small blood vessels in the brain and can lead to strokes and thinking problems. Researchers will collect genetic data, symptoms, and brain MRI images to see how these factors relate. The goal is to bett…

This 10-year study will follow 500 Korean adults with CADASIL, a genetic brain disease that causes strokes and dementia. Researchers will track symptoms, brain scans, memory tests, and genetic information to understand how the disease progresses in Koreans. The goal is to improve…

This study is investigating why some people with migraine with aura also have a small hole in the heart called a PFO. Researchers will compare genetic differences and blood flow patterns between 240 adults who have migraine with aura, some with a PFO and some without. No new trea…

This study is following 500 people with cerebral small vessel disease (CSVD) to see how their genes affect their brain scans, symptoms, and health over time. Participants get genetic testing and MRI scans at the start and again after 1-2 years. The goal is to better understand th…

This study follows 660 adults with CADASIL, a genetic condition that causes strokes and dementia, for up to 5 years. Researchers will use brain scans, memory tests, and blood samples to track how the disease progresses from its earliest stages. The goal is to identify factors tha…

This study collects medical information and biological samples (like blood or tissue) from up to 12,000 people with leukodystrophies—rare disorders that damage the brain's white matter. Researchers will use this data to find new genetic causes, develop biomarkers for future trial…

This study creates a list of people interested in CADASIL research. If you have CADASIL, are at risk, or have a loved one with the condition, you can join. Researchers will then invite you to future studies, making it easier to find volunteers and speed up discoveries about this …