Scientists launch major effort to unlock secrets of rare brain disease CADASIL
NCT ID NCT05677880
First seen Jan 18, 2026 · Last updated Jun 20, 2026 · Updated 31 times
Summary
This study follows 660 adults with CADASIL, a genetic condition that causes strokes and dementia, for up to 5 years. Researchers will use brain scans, memory tests, and blood samples to track how the disease progresses from its earliest stages. The goal is to identify factors that influence disease onset and severity, which could help develop future treatments.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Brown University
RECRUITINGProvidence, Rhode Island, 02912, United States
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Columbia University
RECRUITINGNew York, New York, 10027, United States
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Georgia State University Research Foundation
RECRUITINGAtlanta, Georgia, 30303, United States
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Loyola University
RECRUITINGChicago, Illinois, 60660, United States
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Oregon Health & Science University
RECRUITINGPortland, Oregon, 97239, United States
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University of California
RECRUITINGLos Angeles, California, 90095, United States
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University of California
RECRUITINGSan Francisco, California, 94143, United States
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University of Colorado
RECRUITINGDenver, Colorado, 80204, United States
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University of Texas
NOT_YET_RECRUITINGSan Antonio, Texas, 78249, United States
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University of Texas Health Science Center
NOT_YET_RECRUITINGHouston, Texas, 77030, United States
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University of Utah
RECRUITINGSalt Lake City, Utah, 84112, United States
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University of Washington
RECRUITINGSeattle, Washington, 98195, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this study could reveal early markers and risk factors for CADASIL, pointing toward ways to slow or predict the disease.
What could go wrong
This is an observational study, not a treatment trial. It may not lead to any direct therapy, and results may take years to translate into clinical practice.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.