University Of Wisconsin, Madison

This study tests whether a three-drug combination (liposomal irinotecan, TAS102, and bevacizumab) can help people with metastatic colorectal cancer that has stopped responding to standard treatments. About 50 adults whose cancer is mismatch repair proficient and who have already …

This study tests whether a smartphone app (CHESS Health Connections) helps people with alcohol-related liver disease stop drinking. About 298 participants will use the app alongside usual care for up to 6 months. The goal is to see if the app increases days without alcohol and re…

This study is testing whether a shorter, more intense course of radiation before surgery is as safe and effective as the standard longer course for soft tissue sarcomas. It will involve 30 adults with these rare cancers, comparing five treatments over 1-2 weeks to the usual 25 tr…

This study looks at whether switching from a standard anti-rejection drug to a longer-acting version (Envarsus XR) can reduce bothersome hand tremors in people who have had a pancreas-kidney transplant. About 20 adults who received their transplant 3 months to 5 years ago and dev…

This early-phase study tests a stem cell transplant from a half-matched donor for children with blood cancers or solid tumors that have come back or are hard to treat. The transplant uses a special method to remove certain immune cells, and patients also receive a drug called zol…

This study is testing a new mix of chemotherapy drugs and immunotherapy as a first treatment for people with advanced esophageal or stomach cancer. The goal is to see if this combination works better and causes fewer side effects than current standard treatments. About 52 adults …

This study compares high blood pressure care given by community health workers using a mobile app and remote doctor support to care given directly by a doctor. The goal is to see if the app-assisted approach works just as well at lowering blood pressure. The trial will enroll 460…

This early-stage study tests the safety of a gel containing two HIV drugs (lopinavir/ritonavir) applied inside the anus. It involves 21 adults with HIV who have high-grade anal lesions (precancerous cells). The goal is to find a safe dose and see if the gel can shrink or eliminat…

This study tests two drugs, sirolimus and everolimus, given once a week to see if they can safely target the root causes of aging. Healthy adults aged 55 to 89 will take one of three doses for six weeks. The goal is to find a dose that is safe and could help people stay healthier…

This study is testing a new type of MRI (called 4D flow MRI) to see if it can find dangerous veins in the stomach and throat of people with liver cirrhosis. These veins can burst and cause deadly bleeding. Currently, doctors use a camera down the throat (endoscopy) to check, but …

This study is testing a new automated MRI method to improve images of the liver. It includes healthy adults and people with known or suspected liver disease or iron overload. Participants will have one MRI scan, and researchers will compare the new method to standard techniques t…

This study is testing a new imaging method called FAPI PET/MRI to see if it can find and track prostate cancer that has spread better than current scans. About 30 adults with prostate cancer will each have two research scans. The goal is to improve how doctors detect and monitor …

This study looks at whether a nutrition program based on Oneida culture can reduce stroke risk and slow memory loss in the Oneida Nation. About 85 people aged 7 to 85 will get health coaching, blood tests, and brain checks over one year. The goal is to see if learning about healt…

This study tests whether a group therapy called Cognitive Processing Therapy (CPT) helps reduce PTSD symptoms and rule-breaking in incarcerated people. About 900 adults from 6 prisons will join, and the study lasts up to 24 weeks. Participants must have a current PTSD diagnosis a…

This study tests whether a liquid adhesive called Mastisol helps babies with clubfoot get better results from casting. About 100 infants will be followed for up to 5 years to see if Mastisol reduces skin sores, the need for extra casts, or surgery. The goal is to make standard cl…

This study tests whether a purified CBD medication (Epidiolex) can reduce urinary incontinence in people who recently had a spinal cord injury. Twenty adults with at least two leaks per day will take CBD for 90 days and track their symptoms. The goal is to see if CBD is a safe an…

This study tests whether a gentle electrical current applied to the scalp during a short nap can boost brain activity linked to deep sleep and reduce mental tiredness. About 25 adults who don't feel rested after sleep will take two napping visits while wearing a special cap to me…

This study is testing a very short course of whole breast radiation (just 5 treatments) for women with early-stage breast cancer. Researchers want to see how the breast looks and how patients feel about their appearance, side effects, and quality of life over 5 years. 50 women wh…

This study tests whether taking celecoxib (an anti-inflammatory) plus Tylenol after a parotidectomy (a type of neck surgery) can reduce the need for stronger opioid pain pills like oxycodone. About 84 adults will receive either celecoxib or a placebo, along with Tylenol, and trac…

This study tests whether using the Healthy Minds Program smartphone app can reduce depression symptoms in teenagers. About 200 teens aged 14-19 with elevated depression will use the app for 20 weeks. Researchers will track changes in depression and anxiety scores using standard s…

This early-stage trial tests whether injecting special bone marrow cells (called mesenchymal stromal cells) into the salivary glands is safe and can improve dry mouth. About 36 adults with dry mouth from conditions like Sjogren's disease or graft-versus-host disease will take par…

This study tests whether a 6-week mindfulness skills training program can reduce anxiety and depression in adults who have been recently released from jail or prison. Sixty participants will be randomly assigned to either take the mindfulness classes right away or join a waitlist…

This study is testing a new program that combines counseling and faith to help African American adults with depression. Researchers will work with 12 church groups in Wisconsin to see if the program reduces depression symptoms. The goal is to create a helpful, evidence-based opti…

This study is testing a self-help workbook designed to help people in prison manage anxiety and depression. About 96 adults with moderate to severe symptoms will use the workbook for 8 weeks. Researchers will check if it is practical, acceptable, and helpful for improving mental …

This study looks at whether a 16-week resistance exercise program can reduce symptoms of major depression. Researchers will compare high-dose and low-dose exercise in 200 adults aged 18-65 with depression. The goal is to see if exercise improves mood and brain blood flow, offerin…

This study tests whether nicotine pouches or mini lozenges help people smoke fewer cigarettes. 300 adult smokers who don't plan to quit in the next month will use one of these products (or no product) for a week, then try to stop smoking for 3 weeks. Researchers will track how ma…

This study tests whether adding tranexamic acid (TXA) to hyaluronic acid (HA) facial filler can reduce bruising, swelling, and pain after injection. About 40 adults will receive filler with TXA on one side of the face and plain filler on the other, then rate their bruising. The g…

This early-stage study is testing whether a smartphone app called the Healthy Minds Program is practical and well-liked by people who have had suicidal thoughts in the past month. Fifty adults will use the app for 4 weeks and fill out questionnaires. The goal is to see if the app…

This early-stage study tests whether adding psilocybin (the active ingredient in magic mushrooms) to standard buprenorphine/naloxone treatment is safe for people with opioid use disorder. Ten adults on stable medication will receive two doses of psilocybin while being monitored f…

This study looks at how chronic lymphocytic leukemia (CLL) cells use nutrients like glucose and glutamine compared to normal cells. Researchers will give participants a special drink with harmless tracers and then take blood samples to track the tracers. The goal is to find metab…

This study looks at whether a special recovery model can help older adults (65+) who had delirium after emergency surgery. About 528 participants will be followed for 18 months to track changes in thinking, physical ability, and mood. The goal is to see if this approach improves …

This study aims to adapt a program called Staying Healthy After Childbirth (STAC) to better serve Black women and birthing persons. Researchers will work with community advisors and staff to identify barriers and helpful factors for using the program in community organizations. T…

This study looks at how well older adults (age 60+) can swallow and how healthy their mouths are while they are in the emergency department. Researchers will collect saliva, do simple swallowing and breathing tests, and ask questions. The goal is to learn how common these problem…

This study follows 660 adults with CADASIL, a genetic condition that damages small blood vessels in the brain and can lead to dementia. Researchers will use memory tests, brain scans, and blood samples over 5 years to track how the disease develops. The goal is to better understa…

This study looks at how psilocybin, the active ingredient in magic mushrooms, helps the brain adapt and change. Researchers will give different doses of psilocybin to 60 adults who feel a mild dip in emotional wellbeing. Participants will have brain scans, answer questionnaires, …

This study tests whether a newer, MRI-guided radiation method (MRgART) is gentler on the heart than standard radiation (LINAC) for people with lung, esophageal, or other chest cancers. About 60 adults will receive radiation and have their heart function checked with MRIs and bloo…

This study aims to identify familial hypercholesterolemia (FH), a genetic condition causing high cholesterol, in newborns. Researchers will collect cheek swabs from parents and blood samples from babies over 2 years. The goal is to better understand how to detect FH early in life…

This study creates a list of people interested in CADASIL research. You can join if you are 18 or older and have CADASIL, are at risk, or have a loved one with the condition. By signing up, you allow researchers to contact you about future studies. No treatment is given—this is p…

This study is testing a new online tool called the Care Planning Tool for people who had surgery to fix hypospadias (a birth condition where the urine opening is not at the tip of the penis). About 20 males aged 5 to 65 will use the tool to answer questions about their health, an…

This study aims to see if a special type of ultrasound can safely check a baby's lung health during late pregnancy. Researchers will enroll 16 pregnant women between 32 and 36 weeks for a single 30-minute scan. The goal is to learn if the technique works and gather initial data, …

This study tests a new computer program that reads brain signals to tell if someone is conscious or not. Thirty healthy adults will have their brain activity recorded during both wakefulness and sleep. The goal is to see if a simple, portable setup can accurately detect conscious…

This study follows 65 infants who had a stroke around birth to understand how their brains heal and develop. Researchers use safe brain scans and movement tests to find markers that could guide future treatments. The goal is to learn, not to test a new therapy.

This study will use a smartphone app to track people's daily activities and tick encounters across the United States, especially in the upper Midwest and Northeast. Up to 3,500 participants will log their behaviors for 7 days over a year. The goal is to see if using the app helps…

This study will collect eye images from 1,000 adults aged 50 and older, both healthy and with age-related macular degeneration (AMD), from up to 25 countries. The goal is to create a high-quality dataset that researchers can use to develop artificial intelligence (AI) tools for s…

This study looks at how chemotherapy before surgery affects memory, attention, and other thinking skills in 18 women with advanced ovarian cancer. Participants will take thinking tests over about 10 months. The goal is to understand the mental side effects of treatment, not to ch…

This study looks at how practice on computer tasks can change the way people think and see. Researchers will test healthy adults ages 18-30 and 60-85 to see if training improves skills like vision, attention, and reading. The goal is to understand how learning works, not to treat…

This study looks at how brain activity before major surgery relates to the risk of postoperative delirium—a state of confusion that can occur after surgery. Researchers will monitor 468 older adults (age 60 or older) using EEG and blood tests. The goal is to better understand why…

This study will test if researchers can successfully recruit and keep 30 children aged 3-17 with PANS or PANDAS for one year. The goal is to learn how often these conditions occur and how they change over time. No new treatments are being tested; instead, the focus is on gatherin…

This study tests a new process to help older adults (80+) prepare for major surgery by improving access to a geriatric assessment. Researchers will see if the new process increases the number of patients referred and surgeons using it. Results will be compared to past data.

This study tests whether a virtual version of the Abecedarian Approach, an early learning program, works as well as in-person care for children aged 0-5 who had a brain injury at birth (HIE) or were born very prematurely. Researchers will enroll 225 families in rural areas and me…

This study uses special PET/CT scans to see how advanced prostate cancer becomes resistant to newer hormone therapies like enzalutamide or abiraterone. About 25 men with advanced prostate cancer who are starting or already on these treatments will be followed for up to 2 years. T…

This study aims to understand why some children become carriers of group A strep bacteria without showing symptoms. Researchers will compare children with active strep throat to those who are carriers. The goal is to learn whether carriers need antibiotic treatment. The study inv…

This study looks at how babies' thinking skills grow over time, both in healthy infants and those who had a brain injury around birth. Researchers will use online games and parent questionnaires to measure attention, problem-solving, and language. The goal is to learn more about …

This study looks at whether a protein called PSMA, usually found in prostate cancer, is also present in a certain type of advanced breast cancer (HER2-negative, AR-positive). Researchers will use a special PET/CT scan to measure PSMA levels in 15 participants. The goal is to see …

This study looks at whether a simple ultrasound can measure bladder function as well as an MRI does. Researchers will compare both imaging methods in 80 adults with lower urinary tract symptoms or an enlarged prostate. The goal is to develop a more affordable and widely available…

This study looks at whether letting parents read their child's medical notes on a bedside tablet helps them be more involved and catch safety problems. About 630 parents of hospitalized children under 12 will be randomly assigned to use the tool or receive usual care. Researchers…

This study looks at how to help prisons offer more medications for opioid use disorder (MOUD), like buprenorphine and methadone. Researchers will work with 120 prison sites to see which strategies work best. The goal is to improve health and reduce problems like drug-related inci…

This study looks at how asthma-related airway inflammation may affect brain function and mood. Researchers will compare brain scans, blood and sputum samples, and cognitive tests between 100 adults with severe asthma and healthy volunteers. The goal is to understand links between…

This study enrolls 422 schoolchildren and their families in Oregon to see if air samplers placed in homes can detect viruses that cause respiratory infections. Participants provide nasal swabs and report symptoms over 14 days. The goal is to learn how well air surveillance tracks…

This study looks at whether having a special hospital team that gets to know patients who are frequently hospitalized can improve their care. Researchers will compare patients assigned to this team with those getting usual care. The main goal is to see if these patients are more …

This study explores whether brain stimulation can help people quickly achieve a deep meditative state, normally requiring years of training. Twelve healthy adults who already meditate will wear a special cap to measure brain activity while receiving stimulation and performing gui…

This study looks at whether a computer program called pediatric eCART can help doctors quickly identify children in the hospital who are at risk of serious problems like heart failure or sepsis. Researchers will compare hospital records from before and after the tool was put into…

This study looks at whether metabolic syndrome harms artery function differently in young men versus women, and if a single 30-minute exercise session can temporarily improve it. Researchers will measure blood flow in the neck artery before and after exercise in 48 adults with an…

This study is testing a new AI tool that creates simple, patient-friendly summaries of radiology reports for people with cancer. Researchers want to see if these summaries help patients better understand their scan results and reduce the number of questions doctors get. About 2,0…

This study aims to find out if computer-based cognitive training can improve memory, attention, and problem-solving. Researchers will enroll 1,600 adults with normal vision and no known brain issues. Participants will complete up to 15 hours of brain games and thinking tasks over…

This study looks at whether local anesthesia (numbing only the surgery area) works as well as general anesthesia (being fully asleep) for older adults having inguinal hernia repair. About 80 Veterans aged 60 and older will take part. The goal is to gather information to plan a la…