University Of Wisconsin, Madison

This early-phase trial tests whether an experimental DNA vaccine (pTVG-HP) combined with the immunotherapy drug nivolumab and targeted radiation can help the immune system attack prostate cancer that has returned in a few spots. The study involves 14 men whose cancer has come bac…

This early-phase trial is testing whether MRI-guided radiation therapy (SBRT) can be given at higher doses safely to people with cancer that has spread to the liver. Up to 32 participants will receive 5 radiation sessions over 1.5 to 2 weeks. The main goal is to find the highest …

This phase 2 trial is testing a combination of three chemotherapy drugs plus immunotherapy as a first treatment for advanced esophageal and gastric cancer. For patients with HER2-positive tumors, the targeted drug trastuzumab is also added. The study aims to see if this mix is mo…

This study tests whether a smartphone app called Connections can help people with alcohol-related liver disease stop drinking. About 298 participants from two medical centers will use the app along with their usual care, or just receive usual care alone. The goal is to see if the…

This study tests whether community health workers (CHWs) using a mobile app can manage high blood pressure as effectively as doctors. 460 adults with hypertension in rural Guatemala will be randomly assigned to either CHW-led care with app support and remote doctor supervision, o…

This early-stage study tests a radioactive imaging agent called Y-NM600 in up to 60 people with metastatic cancer who are already on immunotherapy drugs (anti-PD-1 or anti-PD-L1). The main goals are to check safety and find the best dose, and to see if the agent can make the immu…

This early-stage study tests whether a cream made from two HIV drugs (lopinavir/ritonavir) can be safely placed inside the anus to treat high-grade anal growths (AIN 2/3) in people living with HIV. About 21 participants will receive the cream for a few months and be followed for …

This early-stage study tests a new type of stem cell transplant for children whose blood cancers or solid tumors have returned or are hard to treat. The transplant uses a half-matched donor and removes certain immune cells to lower the risk of graft-versus-host disease. A drug ca…

This study looks at whether adding support from a pharmacist or a community health worker helps adults with type 2 diabetes better manage their blood sugar. About 376 people will be placed into one of four groups: usual care, pharmacist help, community health worker help, or both…

This early-phase study tests whether combining a liver-directed chemotherapy (HEPZATO KIT) with two immunotherapy drugs (nivolumab and relatlimab, sold as Opdualag) is safe and effective for people with metastatic melanoma that has spread to the liver. About 15 participants who h…

This study tests whether a combination of varenicline (a pill) and nicotine patches can help people who both smoke cigarettes and use e-cigarettes quit smoking. About 500 participants will take the medications and be followed for 12 months to see if they stay smoke-free. The goal…

This study tests a DNA vaccine (pTVG-AR) combined with hormone therapy and immune-boosting drugs in 60 men with newly diagnosed, high-risk prostate cancer who plan to have their prostate removed. The goal is to see if the vaccine can train the immune system to attack cancer cells…

This study tests whether the drug letermovir can prevent cytomegalovirus (CMV) from coming back in kidney or kidney/pancreas transplant patients who are at high risk. About 90 adults will take letermovir daily for 84 days and be followed for 6 months. The goal is to see if it red…

This study tests two drugs, sirolimus and everolimus, taken once a week to see if they can safely slow the aging process in healthy adults aged 55 to 89. Participants take one of three dose levels for 6 weeks, and researchers monitor side effects and drug levels in the blood. The…

This study compares two ways of giving radiation before surgery for soft tissue sarcoma: a shorter course with higher doses (hypofractionated) versus the standard longer course. The goal is to see if the shorter approach is safe and works as well or better at killing tumor cells.…

This study tests whether giving extra caffeine to very premature babies (born before 30 weeks) can improve kidney oxygen levels and reduce kidney injury. About 114 babies already receiving standard caffeine will get either an extra dose or a placebo. Researchers will monitor kidn…

This study looks at whether switching from a standard anti-rejection drug to a longer-acting version (Envarsus XR) can reduce tremors in people who have had a pancreas-kidney transplant. About 20 adults who have had their transplant between 3 months and 5 years ago and developed …

This study tests whether a new combination of three drugs (liposomal irinotecan, TAS102, and bevacizumab) can help people with advanced colorectal cancer that has stopped responding to standard treatments. The trial will enroll 50 adults whose cancer has spread or cannot be remov…

This study tests whether a nutrition program rooted in Oneida culture can reduce stroke risk factors and slow cognitive decline. About 85 tribal members aged 7 to 85 will receive health coaching, blood work, and imaging over one year. The goal is to improve blood pressure, BMI, a…

This study tests a new type of PET/MRI scan to see if it can better tell the difference between a growing brain tumor and changes caused by radiation or immunotherapy. About 30 adults with brain metastases who have had radiation in the last 2 years will get a single 3-hour scan s…

This study is testing a new automated MRI method to see if it can take clearer pictures of the liver. It will include up to 200 adults (and some children age 7+) who are healthy, have known or suspected liver disease, or have iron overload. Participants will have one MRI scan, an…

This study tests whether a special PET scan (FAPI PET) can better detect active scarring in the lungs of people with fibrotic lung disease. About 50 adults with idiopathic pulmonary fibrosis or fibrotic hypersensitivity pneumonitis will get up to 4 PET/MRI scans. The goal is to i…

This study tests a new imaging method called FAPI PET/MRI to see if it can find and track prostate cancer that has spread better than current scans. About 30 adults with prostate cancer will get two research scans. The goal is to improve how doctors detect and monitor the disease…

This study looks at whether a computer program called pediatric eCART can help doctors quickly identify children in the hospital who are at high risk of serious problems like cardiac arrest or sepsis. Researchers will compare data from before and after the tool was put into use, …

This study is testing whether a special PET/MRI scan can show early on if hormone therapy is shrinking breast cancer before surgery. About 53 postmenopausal women with a certain type of breast cancer will get the scan before and after starting treatment. The goal is to see if the…

This study is testing a new, non-invasive MRI technique (4D flow MRI) to detect dangerous varices in the esophagus and stomach of people with cirrhosis. Currently, patients need an endoscopy—a tube down the throat—to check for these varices, which can burst and cause fatal bleedi…

This study tests whether a combined PET/MRI scan can accurately locate the source of chronic pain that persists for months after joint surgery. About 128 adults with ongoing pain (score 4+ out of 10 for at least 6 months) and healthy volunteers will receive the scan. If successfu…

This study looks at whether a computer program that automatically checks older adults (65+) in the emergency room for fall risk can help prevent future falls. The tool alerts doctors and lets them refer high-risk patients to a special falls clinic. Researchers will compare medica…

This study tests whether applying Mastisol, a liquid adhesive, during clubfoot casting helps babies with clubfeet get better faster and with fewer problems. Researchers will compare outcomes like how many weeks of casting are needed and how often complications like sores or swell…

This early-phase trial tests whether injecting mesenchymal stromal cells (MSCs) into the salivary glands is safe and can ease dry mouth in people with graft-versus-host disease or Sjogren's disease. Up to 36 adults will receive one injection and be monitored for pain and side eff…

This early-phase study is testing whether adding two doses of psilocybin (the active ingredient in magic mushrooms) with counseling is safe for adults with opioid use disorder who are already taking buprenorphine/naloxone (a standard medication). The study will monitor side effec…

This pilot study tests whether Tai Chi or exercise can reduce attention problems in college students with ADHD. Researchers will enroll 145 students and measure changes in inattention symptoms. The goal is to see if these non-drug approaches are feasible and worth studying furthe…

This study tests whether using a mindfulness app for 15 minutes a day over two weeks, plus a storytelling workshop, can improve wellbeing in STEM graduate students at the University of Wisconsin-Madison. Researchers will measure changes in depression, anxiety, stress, sleep, and …

This study tests whether gentle electrical stimulation to the brain during a short nap can improve the quality of sleep and reduce mental tiredness. Twenty-five adults with non-restorative sleep will take two naps while wearing a special cap that records brain activity and delive…

This study tests a smartphone app called STAR that uses machine learning to send personalized messages to people recovering from alcohol use disorder. The goal is to see if these messages can help people stay engaged in recovery and reduce heavy drinking. About 416 participants w…

This study aims to find the best way to add small amounts of human or digital support to a meditation app for people with depression and anxiety. About 688 adults with elevated symptoms will use the Healthy Minds Program app and receive different levels of support. The goal is to…

This study tests whether nicotine pouches or mini lozenges can help people replace cigarettes. 300 adult smokers who aren't ready to quit will use one of these products or no product for a week, then try to stop smoking for 3 weeks. Researchers will track how many cigarettes they…

This study looks at whether listening to your own choice of music can lower anxiety during hand surgery that uses only local anesthetic (you stay awake). About 170 adults will be randomly assigned to hear either their preferred music genre or a standard relaxation track while in …

This study tests whether special speech strategies, like pointing to letters or using rhythm, can help children with cerebral palsy speak more clearly. About 100 kids ages 7 to 17 will practice these techniques with a speech therapist and then have their speech recorded. The goal…

This study tests whether adding tranexamic acid (TXA) to hyaluronic acid (HA) facial filler can reduce bruising, swelling, and pain. About 40 adults will receive the TXA mixture on one side of their face and standard filler on the other, then report their symptoms. The goal is to…

This study tests whether an 8-week mindfulness training program can reduce anxiety and depression in adults returning to the community after incarceration. Sixty participants will be randomly assigned to either the mindfulness program or a waitlist control group. The goal is to s…

This study tests whether using a smartphone meditation app (Healthy Minds Program) for 8 weeks can reduce depression symptoms in teens aged 14-19. 200 participants with elevated depression scores will be randomly assigned to either the meditation app or a hydration tracking app. …

This study is testing a very short course of radiation therapy for early-stage breast cancer, given over just 5 days. Researchers want to see how it affects breast appearance and patients' quality of life. 50 women who have had breast-conserving surgery will be followed for up to…

This study looks at whether doing moderate aerobic exercise right before a therapy session (CBT) helps people with major depression get more out of their treatment. One hundred adults will be randomly assigned to either exercise or rest quietly before each of 8 weekly therapy ses…

This study looks at whether a 16-week resistance exercise program can reduce symptoms of major depression in 200 adults. Participants will do either high or low dose strength training. Researchers will measure changes in mood, thinking, and blood flow in the brain to see if exerc…

This study tests a new faith-based program to reduce depression symptoms in African American adults. About 50 people from Wisconsin church groups will take part. The program combines cognitive behavioral techniques with religious fellowship. If successful, it could become the fir…

This study tests a personalized version of the Healthy Minds Program app to improve long-term well-being in 1100 adults with mild depression symptoms. Participants use the app for 4 weeks and are followed for 3 months. The goal is to see if tailoring the training to each person l…

This study tests whether a nerve block given before surgery (TAP block) works as well as numbing medicine injected into the wound by the surgeon for controlling pain after gynecologic cancer surgery. About 80 women having surgery through a vertical belly cut will take part. The g…

This study compares four different ureteral stents (small tubes placed in the ureter) to find which one causes the fewest symptoms after laser surgery for kidney stones. About 272 adults who need a stent after stone removal will be randomly assigned to one of four stent types. Re…

This study is testing a self-help workbook designed to help people in prison manage anxiety and depression. About 96 adults with moderate to severe symptoms will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is practical, acce…

This study is testing whether two non-invasive brain stimulation techniques can improve arm movement in people who have had a stroke. The techniques involve stimulating the arm muscles and the tongue. The study will enroll 288 participants, including stroke patients and healthy c…

This study tests whether an ambient artificial intelligence tool can reduce the time nurses spend on electronic health record documentation. About 250 nurses and nursing assistants in hospital units will use the AI to automatically draft notes, and researchers will measure change…

This study tests whether a purified CBD medication (Epidiolex) can reduce urinary incontinence in people with a recent spinal cord injury. Twenty adults who have at least two leaks per day will take CBD for 90 days and track their symptoms using a smartphone app. The goal is to s…

This study looks at whether a group therapy called Cognitive Processing Therapy (CPT) helps reduce PTSD symptoms and rule-breaking in incarcerated men and women. About 900 participants from six prisons will join, each for up to 24 weeks. The therapy helps people change unhelpful …

This study tests whether taking celecoxib (an anti-inflammatory) plus Tylenol can reduce the need for stronger opioid pain pills after a parotidectomy (salivary gland surgery). About 84 adults will receive either celecoxib or a placebo, along with Tylenol, and can take opioids if…

This early-stage study tests whether a smartphone app called the Healthy Minds Program is practical and well-liked by people who have had suicidal thoughts in the past month. About 50 adults will use the app for 4 weeks and complete questionnaires. The goal is to see if the app h…

This study looks at 24 people with advanced melanoma who are starting immunotherapy. Researchers will do a special PET/CT scan and a blood test for tumor DNA about 3-4 weeks after the first treatment. The goal is to see if these early tests can predict whether the immunotherapy i…

This study looks at how brain blood flow changes when healthy adults aged 55-69 breathe differently or shift posture, using MRI scans. Participants will also receive a single dose of prazosin or a placebo to see how it affects blood flow. The goal is to better understand the brai…

This study tests whether a new approach called 'Exercise Forecasting' can help people with prolonged-sitting jobs become more active. Twenty participants will wear a smartwatch, answer two questions daily, and receive customized motivational messages. The goal is to see if these …

This study looks at children ages 5 to 15 who test positive for strep throat to understand why some become carriers—meaning they have the bacteria but no symptoms. Researchers will collect throat samples and analyze gene activity to compare carriers with those who have active inf…

This study looks at how neoadjuvant chemotherapy (given before surgery) affects thinking skills like memory and attention in people with advanced ovarian cancer. Researchers will test 18 participants using questionnaires and cognitive tests over about 10 months. The goal is to be…

This study looks at how the brain manages blood flow when blood pressure drops or carbon dioxide levels rise. Healthy adults aged 20-40 will undergo MRI scans while performing breathing exercises and a simulated postural change. Some will receive a single dose of prazosin, a drug…

This study tests whether letting parents read their child's medical notes on a bedside tablet helps them spot safety issues and feel more involved. Researchers will compare 630 families who get tablet access to those who receive usual care. The goal is to see if this simple chang…

This pilot study is testing whether local anesthesia (with sedation) works as well as general anesthesia for inguinal hernia repair in veterans aged 60 and older. The goal is to gather data to plan a larger, more definitive trial. About 80 participants will be followed for 6 mont…

This study looks at how sleep and emotion processing are linked in teenagers with post-traumatic stress disorder (PTSD). Researchers will use a special sleep device to try to improve sleep quality and see if it helps with next-day mood. 180 teens aged 15-18 will take part, comple…

This study is testing a special type of ultrasound called backscatter quantitative ultrasound (bQUS) to see if it can safely check a baby's lung development when the mother is 36 weeks pregnant. Sixteen pregnant women will each have one extra ultrasound scan between 32 and 36 wee…

This study aims to see if a custom-made tumor culture system can predict how oral cavity cancer responds to the immunotherapy drug pembrolizumab before surgery. Twenty participants will provide a biopsy, receive pembrolizumab as standard care, and then have their tumor analyzed. …

This study aims to create a database of vocal health in people aged 4 to 65 with no voice problems, and compare them to children with voice disorders. Participants will perform simple voice tasks into a device that measures airflow and pressure. The goal is to find the best way t…

This study follows 200 infants (3-24 months old) with and without a history of perinatal brain injury to understand how their cognitive skills grow over time. Researchers use virtual games and parent questionnaires to measure attention, language, and problem-solving. All visits h…

This study looks at how common mouth and swallowing problems are in older adults (age 60+) who come to the emergency department. Researchers will collect saliva, do a simple water swallow test, check mouth function, and ask questions. The goal is to learn how these issues relate …

This study aims to find out why hearing aids work well in quiet labs but not in noisy real-world settings. About 45 adults with hearing loss who already use hearing aids will listen to different sound scenarios and rate their experience. The goal is to improve hearing aid perform…

This study enrolls up to 10,000 adults with cancer to see how a special team of experts (a molecular tumor board) uses genetic testing to recommend personalized treatments. Researchers will track whether doctors follow these recommendations and if patients benefit. The goal is to…

This study aims to find better ways to help people who lost their Medicaid coverage due to paperwork issues. Researchers will call 230,000 eligible people to see if a live conversation with a navigator helps them re-enroll more than a recorded message. The goal is to reduce cover…

This early-stage trial is testing whether bicalutamide, a drug typically used for prostate cancer, can change a protein linked to bladder cancer growth. Researchers will compare men with non-muscle invasive bladder cancer who take the drug to those who don't. The goal is to see i…

This study uses special PET/CT scans to see how advanced prostate cancer becomes resistant to newer hormone therapies like enzalutamide or abiraterone. Researchers will track changes in cancer lesions over time in 25 participants. The goal is to better understand resistance patte…

This study tests a new computer program that reads brain activity to tell if someone is conscious or not. Thirty healthy adults will have their brains scanned while awake and asleep. The goal is to see if a simpler, portable version of the test can accurately detect consciousness…

This study is collecting eye images from 1,000 adults aged 50 and older, with or without age-related macular degeneration (AMD), from up to 25 countries. The goal is to create a high-quality, diverse dataset that researchers can use to train artificial intelligence (AI) to screen…

This study looks at how genes and brain scans can help predict recovery from aphasia, a language disorder that often follows a stroke. Researchers will enroll 90 adults aged 40-90 who have had a stroke and have trouble speaking or understanding language. By understanding these bi…

This study looks at how the brain processes and controls speech in healthy adults. Researchers want to understand how people notice their own speech mistakes and learn new sounds. About 117 English-speaking adults with normal hearing and no neurological conditions will take part.…

This study tests whether a newer, MRI-guided radiation method (MRgART) is gentler on the heart than standard radiation (LINAC) for people with lung, esophageal, or other chest cancers. About 60 adults will receive radiation and have their heart function checked via MRI and blood …

This study looks at how training on computer tasks can change the way people think and process information. Healthy adults aged 18-30 or 60-85 with normal vision can join. Participants will complete cognitive tasks over up to 8 weeks to measure learning and thinking skills.

This study looks at whether a gentle nerve stimulation (taVNS) after a single dose of psilocybin can help healthy adults remember the insights they gained during the experience for longer. Researchers will compare memory vividness, brain activity, and well-being between groups th…

This study is for people with rare, undiagnosed genetic conditions that standard tests couldn't identify. Researchers will use whole genome sequencing of the patient and their parents, plus advanced lab work, to find new disease genes and provide a diagnosis. The goal is to give …

This study will follow 600 adults who vape nicotine regularly for at least three years. Researchers will use blood tests, lung CT scans, and heart stress tests to measure changes in artery thickness and lung air trapping. The goal is to understand if long-term e-cigarette use har…

This study follows 660 adults with CADASIL, a genetic condition that causes strokes and dementia, for up to 5 years. Researchers will use brain scans, memory tests, and blood samples to track how the disease progresses from its earliest stages. The goal is to identify factors tha…

This study explores whether mild electrical stimulation of a nerve in the forehead can boost the brain's natural waste-clearing system. Researchers will measure changes in blood flow and cerebrospinal fluid movement in 55 healthy adults and people with mild traumatic brain injury…

This study explores whether a non-invasive brain stimulation technique can help people quickly achieve a deep meditative state, normally only reached after years of training. About 22 healthy adults who already meditate will wear an EEG cap and receive brain stimulation while per…

This study tests whether a virtual version of the Abecedarian Approach, an early childhood education program, can help children ages 0-5 who had hypoxic-ischemic encephalopathy (HIE) or were born very prematurely. Researchers will enroll 225 families and measure parent satisfacti…

This study looks at whether simple, non-invasive eye tests can help predict brain development in newborns with hypoxic-ischemic encephalopathy (HIE), a type of brain injury caused by lack of oxygen. Researchers will measure eye function using visual evoked potential (VEP) and ele…

This study follows 65 infants who had a stroke around birth, tracking their brain development and motor skills over two years. Researchers use MRI scans, brain stimulation, and movement tests to find markers of recovery. The goal is to understand how the brain heals, which could …

This study aims to adapt a program called Staying Healthy After Childbirth (STAC) to better serve Black women and birthing persons. Researchers will work with community advisors and local organizations to identify barriers and facilitators to implementation. The goal is to create…

This study tests a new process to help older adults (age 80+) get a comprehensive geriatric assessment (CGA) before major surgery. The goal is to see if a special implementation package can increase the number of patients referred and assessed. Researchers will compare results to…

This pilot study tests whether a special PET scan (FES-PET/CT) can help doctors find the best dose of tamoxifen for people with metastatic breast cancer that has an ESR1 mutation. These mutations can make standard tamoxifen doses less effective. The study will enroll 12 participa…

This study is testing a new web-based tool called the Care Planning Tool for people who have had surgery to correct hypospadias. About 20 males aged 5 to 65 will use the tool to answer questions about their health and well-being. The goal is to see if the tool is easy to use and …

This study looks at how speech changes over time in people at higher risk for Alzheimer's disease. Researchers will have 165 participants complete speech tasks and surveys on an iPad at home for 3 years. The goal is to see if remote speech tracking is a useful and easy way to mon…

This study looks at whether airway inflammation from asthma can cause brain inflammation and affect mood. Over six visits, 50 adults with mild asthma will complete questionnaires, computer tasks, allergy tests, breathing tests, blood draws, and brain scans. The goal is to underst…

This study looks at oxygen levels in the kidneys of premature babies born before 32 weeks who have a heart condition called patent ductus arteriosus (PDA). Researchers want to see how kidney oxygen relates to the severity of the heart condition and whether it can predict kidney i…

This study tests a tool called TrialTalk™ to see if it helps cancer patients and their doctors communicate more clearly. About 30 patients and their doctors will fill out questionnaires before and after a regular clinic visit. The goal is to see if the tool improves understanding…

This study is testing a new MRI method to take clearer pictures of the abdomen by reducing blurring caused by breathing, heartbeats, and other movements. It will involve 80 participants, including healthy volunteers and patients with liver metastases. The goal is to see if the ne…

This study looks at how brain activity before major surgery might predict delirium afterward. Researchers will monitor 468 older adults (ages 60+) using EEG and blood tests. The goal is to find early warning signs and better understand why some people get confused after surgery.

This study tests a new training program called Better Conversations to help surgeons communicate more clearly with patients. Researchers will compare training led by a specialist versus an automated version. About 580 participants, including surgeons, patients, and stakeholders, …

This study aims to see if short videos featuring Latinx patients and doctors can encourage more Latinx people with diabetes to get regular eye exams. Researchers will survey about 1,500 people and hold small group discussions to measure changes in eye health knowledge and trust i…

This study tests if a gentle, non-invasive electrical stimulation applied to the brain during sleep can temporarily change brain activity, specifically sleep spindles (brain waves linked to memory). Up to 24 healthy adults will have 3 overnight visits to compare real stimulation …

This study looks at ways to help teenagers and young adults with congenital heart disease (CHD) switch from pediatric to adult doctors. Researchers will compare education led by nurses versus doctors to see which works better. About 450 people with CHD, their supporters, and prov…

This study tests a new type of brain stimulation called temporal interference to see if it can temporarily change how different brain regions communicate. Forty healthy adults aged 18-50 will receive stimulation during sleep and wakefulness, and have their brain activity measured…

This study aims to identify different types of familial hypercholesterolemia (FH) in infants and newborns. Expectant parents with FH will provide a cheek swab for genetic testing, and their babies will have 5 blood samples collected over 2 years. The goal is to improve early dete…

This study looks at whether a program with a nurse case manager can help people leaving prison visit a doctor or clinic instead of the emergency room. About 488 adults with a history of substance use and a chronic health condition will take part. Some will get extra support from …

This study looks at whether having a special hospital team that gets to know frequently hospitalized patients can improve their care. About 1200 adults who have been hospitalized two or more times in the past year will take part. Researchers will compare those assigned to the ded…

This study is looking at a protein called PSMA in a specific type of advanced breast cancer (HER2-negative, AR-positive). Researchers want to see if PSMA levels on a PET scan can predict whether the cancer will resist a hormone-blocking drug called bicalutamide. About 15 people w…

This study explores whether a non-invasive brain stimulation technique can help people quickly achieve a deep meditative state, normally only reached after years of training. 48 healthy adults who have never meditated before will wear a special EEG cap and receive brain stimulati…

This study looks at whether breast tumors with high chromosomal instability (CIN) respond better to the chemotherapy drug paclitaxel. About 50 women with breast cancer will receive paclitaxel before surgery. Researchers will measure tumor shrinkage and drug levels to understand h…

This study looks at how bone density in the thigh bone changes after total knee replacement. Researchers will compare two types of implants (cemented vs cementless) and two surgical methods (robotic vs manual). 100 adults aged 55 and older will be followed for up to 26 months to …

This pilot study is looking for ways to tell if endocrine therapy is working in people with a certain type of advanced breast cancer (lobular breast cancer). Researchers will use special PET scans and blood tests to measure estrogen activity before and after starting treatment. T…

This study aims to see if it's possible to enroll and keep children with PANS or PANDAS in a year-long observation. Researchers will track symptoms and outcomes to better understand how these conditions develop and change over time. About 30 children aged 3 to 17 will participate…

This study looks at whether a special recovery plan can help older adults (65+) who had confusion after emergency surgery. Researchers will track thinking, physical, and emotional recovery for 18 months. The goal is to see if the plan improves how well patients bounce back.

This study is for people aged 18-45 who still have hip pain after hip arthroscopy. Researchers will use a special PET/MRI scan to look for problem spots in the hip. The goal is to understand why some people have ongoing pain while others get better. Participants will have one sca…

This study tests a new CT scan method that measures blood flow in the lungs without using contrast dye. About 30 adults will get a 30-minute chest CT to see if the new method gives as much information as the standard scan. The goal is to find a safer way to check lung health.

This study looks at whether a simple ultrasound can do the same job as an MRI for measuring how well the bladder works in people with lower urinary tract symptoms (like trouble urinating). Researchers will compare results from both scans in 80 adults. If ultrasound works, it coul…

This study compares two newer ultrawide field cameras (Clarus and Optos) with the standard imaging system for people with inherited retinal diseases. Researchers want to see if all three cameras give the same information to monitor these conditions. Participants will have their e…

This early-phase study tests whether a special PET scan (using Detectnet) can help doctors plan a more precise and safer dose of radiation therapy (Lutathera) for people with neuroendocrine tumors. Ten participants will receive extra scans before and after treatment to compare ho…

This study looks at how to get more medications for opioid use disorder (MOUD) to people in prison. Researchers will work with 120 prison sites to see which methods work best for increasing access to these life-saving drugs. The goal is to improve health and reduce harm for incar…

This study looks at how babies' brains develop after an injury around birth. Researchers will use fun games and brain wave tests (EEG) to see if they can predict which children might have trouble with thinking and memory later. About 100 babies, both healthy and those with brain …

This study looks at how cancer cells in chronic lymphocytic leukemia (CLL) use nutrients like sugar and glutamine. Researchers will give participants special labeled nutrients and then measure how the cells process them. The goal is to understand cancer cell metabolism better, no…

This study aims to develop a method for collecting human milk remotely (by mail) so researchers can study gene activity. About 50 breastfeeding volunteers in Wisconsin will add a preservative to their milk and ship it to the university. The goal is to see if the milk's genetic ma…

This study aims to find out if computer-based cognitive training can improve memory, attention, and problem-solving. Researchers will enroll 1,600 healthy adults (ages 18-30 or 60-85) who will complete up to 15 hours of brain games and tests over 4-8 weeks. No medication or treat…

This study looks at how starting gender-affirming hormone therapy (GAHT) changes the brain over the first few months. Researchers will measure blood flow, brain structure, and thinking skills like memory and attention in 72 adults before and 4-6 months after starting GAHT. The go…

This study will enroll up to 3,500 people across the United States, especially in the upper Midwest and Northeast, to test whether using a smartphone app (the Tick App) can help track tick encounters and encourage prevention habits like tick checks and showering. Participants wil…

This study creates a registry of people interested in CADASIL, a rare genetic brain disease. If you have CADASIL, are at risk, or have a loved one with it, you can join. Your name will be added to a list to be invited to future research studies. No treatment is given—this is abou…

This study looks at how psilocybin, the active ingredient in magic mushrooms, helps the brain adapt and improve emotional wellbeing. Researchers will give 60 adults with mild emotional decline different doses of psilocybin along with other medications, then use brain scans and qu…

This study is testing a new, non-invasive tool called fetal magnetocardiography (fMCG) to better monitor the heart rhythms of babies in the womb. Current methods like ultrasound have limits, and fMCG may provide clearer information. The study will include up to 450 pregnant women…

This study looks at how asthma-related inflammation in the lungs might affect the brain and contribute to depression and anxiety. Researchers will compare brain scans, blood tests, and breathing tests between 100 adults with asthma and healthy volunteers. The goal is to understan…

This study tests a new imaging method called qDSA that measures blood flow before, during, and after a procedure to block blood supply to liver tumors. Up to 20 adults having liver embolization will take part. The goal is to see if qDSA helps doctors better control the treatment.

This study is testing a new AI tool that creates patient-friendly summaries of radiology reports for people with cancer. The goal is to see if these easy-to-read summaries help patients better understand their scan results and reduce the number of questions doctors receive. About…

This study looks at whether metabolic syndrome harms the arteries in the neck differently in young men versus women, and if one 30-minute exercise session can improve artery function. Researchers will test 48 young adults with and without metabolic syndrome over four visits. The …

This study collects tissue samples from women with and without preeclampsia during C-sections to examine blood vessel function. Researchers focus on a protein called AT2R, which may play a role in the condition. The goal is to better understand how preeclampsia affects blood vess…