University Of Wisconsin, Madison

This early-phase trial tests whether an experimental DNA vaccine (pTVG-HP) combined with the immunotherapy drug nivolumab and targeted radiation can help the immune system attack prostate cancer that has returned in a few spots. The study involves 14 men whose cancer has come bac…

This early-phase study tests a radioactive imaging agent called Y-NM600 in people with metastatic cancer who are already receiving immunotherapy drugs (anti-PD-1 or anti-PD-L1). The goal is to find a safe dose and see if the agent can help the drugs work better. Up to 60 particip…

This study tests whether community health workers, guided by a mobile app and remote doctor oversight, can manage high blood pressure as effectively as a physician. About 460 adults with hypertension in rural Guatemala will receive care from either a health worker with the app or…

This study compares two ways of giving radiation before surgery for soft tissue sarcoma: a shorter course with higher doses (hypofractionated) versus the standard longer course. The goal is to see if the shorter approach is safe and works as well or better at killing tumor cells.…

This study tests whether giving extra caffeine to very premature babies (born before 30 weeks) can improve kidney oxygen levels and reduce kidney injury. About 114 babies already receiving standard caffeine will get either an extra dose or a placebo. Researchers will monitor kidn…

This study tests a new approach for people with advanced melanoma that has spread to the liver. It combines a liver-directed chemotherapy (HEPZATO KIT) with two immunotherapy drugs (nivolumab and relatlimab). The goal is to see if this combination is safe and works better than cu…

This study tests whether taking a low dose of sirolimus or everolimus once a week can safely slow the aging process in healthy adults aged 55 to 89. Participants take the drug for 6 weeks, and researchers monitor side effects and drug levels in the blood. The goal is to find a do…

This study tests a smartphone app that uses machine learning to send personalized messages to people recovering from alcohol use disorder. The goal is to see if these messages can help participants reduce heavy drinking and stay engaged with their recovery. About 416 adults who h…

This study tests a DNA vaccine (pTVG-AR) combined with hormone therapy and immune-boosting drugs in 60 men with newly diagnosed, high-risk prostate cancer who plan to have their prostate removed. The goal is to see if the vaccine can train the immune system to attack cancer cells…

This study tests whether a smartphone app called CHESS Health Connections can help people with alcohol-related liver disease stay sober. About 298 participants will use the app along with their usual care for up to 6 months. The goal is to reduce drinking and prevent liver diseas…

This study looks at whether switching from a standard anti-rejection drug to a longer-acting version (Envarsus XR) can reduce tremors in people who have had a pancreas-kidney transplant. About 20 adults who have had their transplant between 3 months and 5 years ago and developed …

This study tests a new mix of chemotherapy drugs and immunotherapy for people with advanced esophageal or stomach cancer. The goal is to see if this combination works better and causes fewer side effects than current treatments. About 52 adults with these cancers will take part, …

This study tests whether the drug letermovir can prevent cytomegalovirus (CMV) infection from coming back in kidney or kidney/pancreas transplant patients at high risk. About 90 adults who have already had a CMV infection will take letermovir for about 6 months. The goal is to se…

This early-stage study tests a new type of stem cell transplant for children whose blood cancers or solid tumors have returned or are hard to treat. Doctors use a special method to remove certain immune cells from the donor's stem cells and give a drug called zoledronate after tr…

This study tests whether a new combination of three drugs (liposomal irinotecan, TAS102, and bevacizumab) can help people with advanced colorectal cancer that has stopped responding to standard treatments. The trial will enroll 50 adults whose cancer has spread or cannot be remov…

This study tests whether a special PET scan (FES-PET) can help find the best dose of tamoxifen for people with metastatic breast cancer that has an ESR1 mutation. These mutations can make standard tamoxifen doses less effective. The study will enroll 12 participants and use imagi…

This study tests whether a nutrition program rooted in Oneida culture can reduce stroke risk factors and slow cognitive decline. About 85 tribal members aged 7 to 85 will receive health coaching, blood work, and imaging over one year. The goal is to improve blood pressure, BMI, a…

This study tests whether nicotine pouches or mini lozenges can help people replace cigarettes. 300 adult smokers will use one of these products or no product for a week, then try to stop smoking for 3 weeks. Researchers will track how many cigarettes they smoke and how strong the…

This study looks at whether adding support from a pharmacist or a community health worker helps adults with type 2 diabetes better manage their blood sugar and medications. About 376 adults with uncontrolled diabetes will be placed into one of four groups: usual care, pharmacist …

This early-stage study tests the safety of a gel made from HIV medications (lopinavir/ritonavir) applied inside the anus. It is for people with HIV who have high-grade anal pre-cancerous lesions (AIN 2/3). About 21 participants will use the gel for 3 months and be followed for 40…

This study tests a special PET scan that uses a tracer called FAPI to see active scarring in the lungs. Researchers want to learn if this scan can better diagnose and track fibrotic lung diseases like IPF and hypersensitivity pneumonitis. About 50 adults will get up to 4 PET/MRI …

This study tests a new imaging agent called FAPI to see if it can find prostate cancer tumors better than current scans. About 30 adults with prostate cancer will get two PET/MRI scans. The goal is to improve how doctors detect and monitor the disease.

This study looks at whether a computer program called pediatric eCART can help doctors quickly identify children in the hospital who are at high risk of serious problems like cardiac arrest or sepsis. Researchers will compare data from before and after the tool was put into use, …

This study is testing whether a special PET/MRI scan can show early on if hormone therapy is shrinking breast cancer before surgery. About 53 postmenopausal women with a certain type of breast cancer will get the scan before and after starting treatment. The goal is to see if the…

This study is testing a new, non-invasive MRI technique (4D flow MRI) to detect dangerous varices in the esophagus and stomach of people with cirrhosis. Currently, patients need an endoscopy—a tube down the throat—to check for these varices, which can burst and cause fatal bleedi…

This study is testing a new automated MRI method to improve liver image quality. It involves 200 participants, including healthy adults and people with known or suspected liver disease or iron overload. Participants will have one MRI scan, and researchers will compare the new met…

This study tests whether a combined PET/MRI scan can accurately locate the source of chronic pain that persists for months after joint surgery. About 128 adults with ongoing pain (score 4+ out of 10 for at least 6 months) and healthy volunteers will receive the scan. If successfu…

This study tests a special PET scan to see if it can better tell the difference between active brain tumors and changes caused by radiation or immunotherapy. About 30 adults with brain metastases who have had radiation in the last 2 years will get a single PET/MRI scan. The goal …

This study looks at whether a computer system in the emergency room can automatically screen older adults (65+) for their risk of falling in the future. If the system finds someone at high risk, it helps the doctor refer them to a special falls clinic before they go home. Researc…

This study tests if a liquid adhesive called Mastisol helps babies with clubfoot get better results from casting. About 100 infants will be followed for up to 5 years to see if it reduces skin problems and the need for extra procedures. The goal is to make standard treatment easi…

This study tests whether a nerve block given before surgery (TAP block) works as well as numbing medicine injected into the wound by the surgeon for controlling pain after gynecologic cancer surgery. About 80 women having surgery through a vertical belly cut will take part. The g…

This study compares four different ureteral stents (small tubes placed in the ureter) to find which one causes the fewest symptoms after laser surgery for kidney stones. About 272 adults who need a stent after stone removal will be randomly assigned to one of four stent types. Re…

This study is testing a self-help workbook designed to help people in prison manage anxiety and depression. About 96 adults with moderate to severe symptoms will use the workbook for 8 weeks and be followed for 13 weeks total. The goal is to see if the workbook is practical, acce…

This study aims to find the most effective way to help people who both smoke cigarettes and use e-cigarettes quit smoking. Researchers will test different combinations of treatments, including medication and nicotine patches, in 500 participants over 12 months. The goal is to see…

This study aims to find the best way to add small amounts of human or digital support to a meditation app for people with depression and anxiety. About 688 adults with elevated symptoms will use the Healthy Minds Program app and receive different levels of support. The goal is to…

This study is testing whether two non-invasive brain stimulation techniques can improve arm movement in people who have had a stroke. The techniques involve stimulating the arm muscles and the tongue. The study will enroll 288 participants, including stroke patients and healthy c…

This study looks at whether resistance exercise (like weight lifting) can reduce symptoms of major depression. Two hundred adults with depression will do either a high or low dose of resistance training for 16 weeks. Researchers will measure changes in mood, thinking, and blood f…

This study tests whether an ambient artificial intelligence tool can reduce the time nurses spend on electronic health record documentation. About 250 nurses and nursing assistants in hospital units will use the AI to automatically draft notes, and researchers will measure change…

This study looks at whether listening to your own choice of music can lower anxiety during hand surgery done with only local anesthetic (you're awake). About 170 adults will be randomly assigned to hear either their preferred music or a standard relaxation track while in the oper…

This early-stage trial tests whether injecting mesenchymal stromal cells (MSCs) from a person's own bone marrow into their salivary glands is safe and can improve dry mouth. The study includes 36 adults with dry mouth from conditions like Sjogren's disease or graft-versus-host di…

This study tests two non-drug treatments for college students with ADHD. The goal is to see if motor attention training (like tai chi) can reduce symptoms of inattention. About 145 students with a documented ADHD diagnosis will participate. The study also checks if wireless brain…

This study tests whether a gentle electrical current applied to the brain during a short nap can boost restorative sleep and reduce mental fatigue. Researchers will monitor brain activity with a special cap and ask participants about their sleep quality and mood. The goal is to f…

This early-stage study tests whether adding two doses of psilocybin (the active ingredient in magic mushrooms) to standard buprenorphine/naloxone treatment is safe for adults with opioid use disorder. Ten participants will be closely monitored for side effects and changes in with…

This study looks at how women with early-stage breast cancer feel about their appearance and quality of life after a very short course of radiation (5 days instead of weeks). 50 participants will be followed for up to 5 years. The goal is to see if this ultra-short treatment is b…

This study tests whether a purified CBD medication (Epidiolex) can reduce urinary incontinence in people with a recent spinal cord injury. Twenty adults who have at least two leaks per day will take CBD for 90 days and track their symptoms using a smartphone app. The goal is to s…

This study looks at whether mindfulness and storytelling can improve the wellbeing of STEM graduate students at the University of Wisconsin-Madison. About 250 students will take part, and researchers will track changes in stress, anxiety, depression, sleep, and burnout over up to…

This study looks at whether a group therapy called Cognitive Processing Therapy (CPT) helps reduce PTSD symptoms and rule-breaking in incarcerated men and women. About 900 participants from six prisons will join, each for up to 24 weeks. The therapy helps people change unhelpful …

This study looks at whether doing moderate aerobic exercise right before a therapy session helps people with depression get more out of their treatment. One hundred adults with major depression will either exercise or rest quietly before each of 8 weekly cognitive behavioral ther…

This study looks at whether speech supplementation strategies—like pointing to letters or using special emphasis—can make it easier for children with cerebral palsy (ages 7-17) to be understood by others. Participants will practice these strategies with a speech therapist and the…

This study tests whether a faith-based program can reduce depression symptoms in African American adults. About 50 people from church groups in Wisconsin will take part. The program combines counseling and faith fellowship to improve mental health. If successful, it could become …

This study tests whether taking celecoxib (an anti-inflammatory) plus Tylenol can reduce the need for stronger opioid pain pills after a parotidectomy (salivary gland surgery). About 84 adults will receive either celecoxib or a placebo, along with Tylenol, and can take opioids if…

This study tests whether a smartphone app called Healthy Minds Program can help reduce depression in teenagers. About 200 teens aged 14-19 with moderate to severe depressive symptoms will use the app for 20 weeks. Researchers will track changes in depression and anxiety scores to…

This study aims to improve the Healthy Minds Program app by creating a personalized training plan for each user. Researchers will enroll 1100 adults with mild depression symptoms to test if a data-driven approach can boost long-term well-being. Participants use the app for 4 week…

This study tests whether adding tranexamic acid (TXA) to hyaluronic acid filler reduces bruising, swelling, and pain after facial injections. 40 adults interested in filler will receive TXA on one side of the face and a placebo on the other, then report their bruising intensity a…

This early-stage study tests whether a smartphone app called the Healthy Minds Program is practical and well-liked by people who have had suicidal thoughts in the past month. About 50 adults will use the app for 4 weeks and complete questionnaires. The goal is to see if the app h…

This study looks at oxygen levels in the kidneys of very premature babies (born before 32 weeks) who have a common heart condition called patent ductus arteriosus (PDA). Researchers want to see how kidney oxygen relates to the severity of the PDA and signs of kidney injury. They …

This study explores whether a special ultrasound technique (bQUS) can safely and effectively assess a baby's lung development during late pregnancy. Sixteen pregnant women between 32 and 36 weeks will receive a single 30-minute ultrasound. The goal is to see if the method works a…

This study is looking at a protein called PSMA in a specific type of advanced breast cancer (HER2-negative, AR-positive). Researchers want to see if PSMA levels on a PET scan can predict whether the cancer will resist a hormone-blocking drug called bicalutamide. About 15 people w…

This study explores whether a non-invasive brain stimulation technique can help people quickly achieve a deep meditative state, normally only reached after years of training. 48 healthy adults who have never meditated before will wear a special EEG cap and receive brain stimulati…

This study follows 660 adults with or at risk for CADASIL, a genetic condition that damages small blood vessels in the brain and can lead to dementia. Over 5 years, researchers will use memory tests, brain scans, and blood tests to track how the disease progresses. The goal is to…

This study aims to find different types of familial hypercholesterolemia (FH) in newborns. Parents give a cheek swab for genetic testing, and babies provide 5 blood samples over 2 years. The goal is to improve early detection and understanding of this inherited high-cholesterol c…

This study aims to learn how often older adults (age 60+) in the emergency department have trouble swallowing or with mouth health. Researchers will use simple tests like a water swallow test and mouth exams, plus surveys, to find links with other health issues. The goal is to be…

This study looks at how healthy adults control their speech, including how the brain detects errors and learns new sounds. Researchers will measure brain activity and speech patterns in 117 English-speaking adults with normal hearing. The goal is to better understand the basic me…

This study aims to see if culturally tailored videos can help Latinx people with diabetes understand the importance of eye exams and trust their healthcare team. Researchers will survey about 1,500 people and hold small group discussions with 20 patients. The goal is to find bett…

This study looks at whether breast tumors with high chromosomal instability (CIN) respond better to the chemotherapy drug paclitaxel. About 50 women with breast cancer will receive paclitaxel before surgery. Researchers will measure tumor shrinkage and drug levels to understand h…

This study looks at how brain activity before major surgery is linked to delirium (sudden confusion) after surgery. Researchers will monitor about 468 older adults using EEG and other tests. The goal is to better understand delirium, not to test a new treatment.

This study looks at how bone density in the thigh bone changes after total knee replacement. Researchers will compare two types of implants (cemented vs cementless) and two surgical methods (robotic vs manual). 100 adults aged 55 and older will be followed for up to 26 months to …

This study aims to see if researchers can create a personalized tumor model from a biopsy that predicts how a patient's oral cancer will respond to the immunotherapy drug pembrolizumab before surgery. About 20 adults with advanced oral cancer will participate. The goal is to find…

This study looks at how airway inflammation from asthma might change brain activity and relate to feelings of depression or anxiety. Over six visits, 50 adults with mild asthma will answer questionnaires, do computer tasks, take breathing and allergy tests, give blood samples, an…

This study explores whether a non-invasive brain stimulation technique can help people quickly achieve a deep meditative state, normally only reached after years of training. About 22 healthy adults who already meditate will wear an EEG cap and receive brain stimulation while per…

This study looks at whether eye function tests can help predict future development in newborns with hypoxic-ischemic encephalopathy (HIE), a type of brain injury. Researchers will compare eye test results between healthy babies and those with HIE to see if these tests can improve…

This study looks at whether a live phone call from a Navigator can help people who lost their Medicaid coverage due to paperwork issues get re-enrolled. Researchers will compare live calls to pre-recorded messages. The study involves up to 230,000 people in Wisconsin who lost Med…

This study tests whether a 6-week mindfulness skills training program can help reduce anxiety and depression in adults who have recently been released from jail or prison. Researchers will compare participants who take the mindfulness classes with a waitlist group that receives t…

This study aims to adapt a program called Staying Healthy After Childbirth (STAC) to better serve Black women and birthing persons. Researchers will work with community groups to identify barriers and helpful factors, then test the adapted program with 46 participants. The goal i…

This study involves 630 parents of hospitalized children under 12. Some parents will get a bedside tablet to read their child's medical notes, while others receive usual care. Researchers want to see if this access helps parents spot safety concerns and become more involved in th…

This pilot study is looking for ways to tell if endocrine therapy is working in people with a certain type of advanced breast cancer (lobular breast cancer). Researchers will use special PET scans and blood tests to measure estrogen activity before and after starting treatment. T…

This study aims to see if it's possible to enroll and keep children with PANS or PANDAS in a year-long observation. Researchers will track symptoms and outcomes to better understand how these conditions develop and change over time. About 30 children aged 3 to 17 will participate…

This study looks at how speech changes in people at higher risk for Alzheimer's disease. About 165 adults aged 40-80 will record their speech at home using an iPad over 3 years. The goal is to see if remote speech tracking is a useful and easy way to monitor thinking and memory c…

This study tests whether mild stimulation of a nerve in the head can improve blood flow and help the brain clear waste, which may slow cognitive decline. Researchers will enroll 55 healthy adults and people with mild traumatic brain injury or post-concussion syndrome. Participant…

This study tests whether a virtual version of the Abecedarian Approach—a proven early learning program—works as well as in-person care for children aged 0-5 who had a brain injury at birth (HIE) or were born very early (before 28 weeks). About 225 families in rural areas will par…

This study is testing a new web-based tool to help men and boys who had surgery for hypospadias track their health over time. About 20 participants will answer questions about urinary, sexual, and mental health to see if the tool is easy to use and helpful. The goal is to improve…

This study tests a new type of electrical brain stimulation called temporal interference to see if it can temporarily change how different parts of the brain communicate. Researchers will enroll 40 healthy adults aged 18-50. Participants will receive stimulation during sleep and …

This study uses MRI to measure how brain blood flow changes when healthy adults (ages 20-40) shift posture or breathe more carbon dioxide. It aims to understand normal brain blood flow regulation, not to treat any disease. Participants must be nonsmokers, within a certain height …

This study tests a tool called TrialTalk™ to see if it helps cancer patients and their doctors communicate better. About 30 patients and their doctors will fill out questionnaires before and after a regular clinic visit. The goal is to learn if the tool improves understanding and…

This study looks at whether a special recovery plan can help older adults (65+) who had confusion after emergency surgery. Researchers will track thinking, physical, and emotional recovery for 18 months. The goal is to see if the plan improves how well patients bounce back.

This study tests a new computer program that reads brain activity to tell if a person is conscious or not. Thirty healthy adults will have their brains stimulated with magnetic pulses while they are awake and asleep. The goal is to see if the program can accurately detect conscio…

This study looks at how chemotherapy before surgery affects thinking and memory in people with advanced ovarian cancer. Researchers will test 18 participants over about 10 months using simple mental tasks. The goal is to better understand cognitive changes during treatment, not t…

This study uses MRI to measure how brain blood flow changes when healthy adults aged 55-69 shift posture or breathe more carbon dioxide. The goal is to understand normal brain blood flow responses, not to treat any disease. Participants must be nonsmokers, postmenopausal women or…

This study uses special PET/CT scans to see how advanced prostate cancer tumors become resistant to common hormone therapies like enzalutamide or abiraterone. About 25 men with advanced prostate cancer who are starting or already on these treatments will get two types of scans ov…

This study looks at how genes and brain scans can help predict language recovery in people who have aphasia after a stroke. Researchers will study 90 adults aged 40-90 with a history of stroke to understand why recovery varies so much. The goal is to find better ways to predict o…

This study tests whether a newer, MRI-guided radiation method (MRgART) is gentler on the heart than standard radiation for people with lung, esophageal, or other chest cancers. About 60 adults will receive radiation and undergo heart MRIs and blood tests to see how their heart fu…

This study looks at whether a gentle nerve stimulation (taVNS) after a single dose of psilocybin can help healthy adults remember the insights they gained during the experience for longer. Researchers will compare memory vividness, brain activity, and well-being between groups th…

This study is for people aged 18-45 who still have hip pain after hip arthroscopy. Researchers will use a special PET/MRI scan to look for problem spots in the hip. The goal is to understand why some people have ongoing pain while others get better. Participants will have one sca…

This study will collect eye images from 1,000 adults aged 50 and older, both healthy and those with age-related macular degeneration (AMD), from up to 25 countries. The goal is to create a diverse, high-quality dataset that researchers can use to develop artificial intelligence (…

This study tests a new CT scan method that measures blood flow in the lungs without using contrast dye. About 30 adults will get a 30-minute chest CT to see if the new method gives as much information as the standard scan. The goal is to find a safer way to check lung health.

This study looks at whether a simple ultrasound can do the same job as an MRI for measuring how well the bladder works in people with lower urinary tract symptoms (like trouble urinating). Researchers will compare results from both scans in 80 adults. If ultrasound works, it coul…

This study compares two newer ultrawide field cameras (Clarus and Optos) with the standard imaging system for people with inherited retinal diseases. Researchers want to see if all three cameras give the same information to monitor these conditions. Participants will have their e…

This early-phase study tests whether a special PET scan (using Detectnet) can help doctors plan a more precise and safer dose of radiation therapy (Lutathera) for people with neuroendocrine tumors. Ten participants will receive extra scans before and after treatment to compare ho…

This study looks at how to get more medications for opioid use disorder (MOUD) to people in prison. Researchers will work with 120 prison sites to see which methods work best for increasing access to these life-saving drugs. The goal is to improve health and reduce harm for incar…

This study enrolls up to 10,000 adults with cancer to see how often doctors follow recommendations from a special team (molecular tumor board) that reviews each patient's tumor genetic test results. Researchers will track whether these personalized treatment suggestions actually …

This study tests a new approach to radiation therapy for liver tumors that have spread from other cancers. Using real-time MRI guidance, doctors can adjust the radiation dose to target tumors more precisely while protecting nearby organs. The goal is to find the highest safe dose…

This study tests whether a special hospital team (Primary Hospital Provider) can provide better, more consistent care for adults who are hospitalized often. Researchers will compare patients assigned to this team with those getting usual care, looking at how many return to the sa…

This study looks at how training on computer tasks can change the way people think and process information. Healthy adults aged 18-30 or 60-85 with normal vision can join. Participants will complete cognitive tasks over up to 8 weeks to measure learning and thinking skills.

This study looks at how babies' brains develop after an injury around birth. Researchers will use fun games and brain wave tests (EEG) to see if they can predict which children might have trouble with thinking and memory later. About 100 babies, both healthy and those with brain …

This study looks at how cancer cells in chronic lymphocytic leukemia (CLL) use nutrients like sugar and glutamine. Researchers will give participants special labeled nutrients and then measure how the cells process them. The goal is to understand cancer cell metabolism better, no…

This study aims to develop a method for collecting human milk remotely (by mail) so researchers can study gene activity. About 50 breastfeeding volunteers in Wisconsin will add a preservative to their milk and ship it to the university. The goal is to see if the milk's genetic ma…

This study tests a new training program called Better Conversations to help surgeons communicate more clearly with patients. Researchers will compare specialist-led training versus automated training by recording surgical consultations and surveying patients. The goal is to see i…

This study looks at how to best help teens and young adults with congenital heart disease (CHD) move from pediatric to adult care. Researchers will compare education led by nurses versus doctors to see which approach helps patients find adult doctors more easily. About 450 people…

This study tests if a non-invasive electrical stimulation method called TI-TES can temporarily alter brain activity during sleep, specifically sleep spindles. Up to 24 healthy adults in Wisconsin will each spend 3 nights in the lab. The goal is to understand how different stimula…

This study looks at whether combining a special PET/CT scan with a blood test for tumor DNA can help doctors predict which patients with advanced melanoma will respond to immunotherapy. About 24 adults with stage III or IV melanoma will have their scans and blood tested before an…

This study aims to find out if computer-based cognitive training can improve memory, attention, and problem-solving. Researchers will enroll 1,600 healthy adults (ages 18-30 or 60-85) who will complete up to 15 hours of brain games and tests over 4-8 weeks. No medication or treat…

This study looks at how starting gender-affirming hormone therapy (GAHT) changes the brain over the first few months. Researchers will measure blood flow, brain structure, and thinking skills like memory and attention in 72 adults before and 4-6 months after starting GAHT. The go…

This study will enroll up to 3,500 people across the United States, especially in the upper Midwest and Northeast, to test whether using a smartphone app (the Tick App) can help track tick encounters and encourage prevention habits like tick checks and showering. Participants wil…

This study looks at how babies' thinking skills grow over time, including healthy infants and those who had a brain injury around birth. Researchers will use fun online games and parent questionnaires to measure attention and learning. The goal is to better understand how early b…

This early-stage trial is testing whether bicalutamide, a drug typically used for prostate cancer, can change a protein linked to bladder cancer growth. About 80 adult men with non-invasive bladder cancer will either receive the drug or no study drug. The goal is to see if the dr…

This study tests a new approach called 'Exercise Forecasting' to help people with prolonged-sitting jobs become more active. Twenty participants will wear a smartwatch, answer daily questions, and receive customized motivational messages. The goal is to see if these messages can …

This study looks at why some children become carriers of group A strep bacteria without showing symptoms. Researchers will compare 30 children with active strep throat and 30 carriers to understand gene differences. The goal is to learn if carriers truly need antibiotic treatment…

This study creates a registry of people interested in CADASIL, a rare genetic brain disease. If you have CADASIL, are at risk, or have a loved one with it, you can join. Your name will be added to a list to be invited to future research studies. No treatment is given—this is abou…

This study aims to find out why hearing aids work well in quiet labs but not in noisy real-world settings. About 45 adults with hearing loss who already use hearing aids will test different sound-enhancement settings in simulated environments. They will rate how well they underst…

This study looks at how psilocybin, the active ingredient in magic mushrooms, helps the brain adapt and improve emotional wellbeing. Researchers will give 60 adults with mild emotional decline different doses of psilocybin along with other medications, then use brain scans and qu…

This study is testing a new way to take MRI pictures of the abdomen that reduces blurring caused by breathing and other movements. Researchers will try the method on 80 healthy adults and people with liver tumors to see if it produces clearer images. The goal is to improve image …

This study is for people with rare, undiagnosed genetic conditions that standard tests couldn't identify. Researchers will use advanced genetic analysis to discover new disease genes and provide diagnoses. Up to 1,000 participants will be enrolled to help expand knowledge of gene…

This study looks at whether local anesthesia (numbing only the surgery area) works as well as general anesthesia (being fully asleep) for older adults having hernia repair. About 80 Veterans aged 60 and older will take part and be followed for 6 months. The main goal is to gather…

This study is testing a new, non-invasive tool called fetal magnetocardiography (fMCG) to better monitor the heart rhythms of babies in the womb. Current methods like ultrasound have limits, and fMCG may provide clearer information. The study will include up to 450 pregnant women…

This study aims to create a large database of healthy voices from people aged 4 to 65. Researchers will compare different ways to measure voice function in children and adults, and also look at differences between healthy voices and those with voice problems. Participants attend …

This study looks at how asthma-related inflammation in the lungs might affect the brain and contribute to depression and anxiety. Researchers will compare brain scans, blood tests, and breathing tests between 100 adults with asthma and healthy volunteers. The goal is to understan…

This study tests a new imaging method called qDSA that measures blood flow before, during, and after a procedure to block blood supply to liver tumors. Up to 20 adults having liver embolization will take part. The goal is to see if qDSA helps doctors better control the treatment.

This study is testing a new AI tool that creates patient-friendly summaries of radiology reports for people with cancer. The goal is to see if these easy-to-read summaries help patients better understand their scan results and reduce the number of questions doctors receive. About…

This study follows 600 adults who regularly vape nicotine to see how it affects their heart and lungs over time. Researchers will use ultrasound and CT scans to measure artery thickness and lung damage. The goal is to understand the long-term health risks of e-cigarette use, espe…

This study looks at whether a short program with a nurse case manager can help people leaving prison get medical care instead of going to the emergency room. About 488 adults with a history of substance use and a chronic health condition will take part. Some will get extra help f…

This study looks at whether metabolic syndrome harms the arteries in the neck differently in young men versus women, and if one 30-minute exercise session can improve artery function. Researchers will test 48 young adults with and without metabolic syndrome over four visits. The …

This study looks at how sleep and emotion processing are linked in teenagers with post-traumatic stress disorder (PTSD). Researchers will test if improving sleep quality can help teens feel better the next day. About 180 teens aged 15-18 will take part in sleep studies, surveys, …

This study follows 65 infants who had a stroke around birth to understand how their brains recover. Researchers use safe MRI scans, brain stimulation, and movement tests over the first two years of life. The goal is to find signs that predict recovery, which could lead to better …

This study collects tissue samples from women with and without preeclampsia during C-sections to examine blood vessel function. Researchers focus on a protein called AT2R, which may play a role in the condition. The goal is to better understand how preeclampsia affects blood vess…

This study tests whether a new process can help more older adults get a special health check-up before major surgery. The check-up, called a geriatric assessment, looks at overall health to help plan care. Researchers will compare how many people use the new process versus past p…