University Of Wisconsin, Madison

This early-stage study tests the safety of a gel containing two HIV drugs (lopinavir/ritonavir) applied inside the anus. It involves 21 adults with HIV who have high-grade anal lesions (precancerous cells). The goal is to find a safe dose and see if the gel can shrink or eliminat…

This study tests two drugs, sirolimus and everolimus, given once a week to see if they can safely target the root causes of aging. Healthy adults aged 55 to 89 will take one of three doses for six weeks. The goal is to find a dose that is safe and could help people stay healthier…

This study tests whether a nutrition program based on Oneida culture can reduce stroke risk and slow memory loss in community members aged 7 to 85. Participants will get health coaching, blood tests, and brain function checks over one year. The goal is to see if traditional foods…

This study compares high blood pressure care given by community health workers using a mobile app and remote doctor support to care given directly by a doctor. The goal is to see if the app-assisted approach works just as well at lowering blood pressure. The trial will enroll 460…

This study tests if a smartphone app called CHESS Health Connections can help people with alcohol-related liver disease stop drinking. About 298 participants from two medical centers will use the app for up to 6 months, and researchers will track their alcohol use and overall hea…

This study tests whether a 6-week mindfulness skills training program can reduce anxiety and depression in adults who have been recently released from jail or prison. Sixty participants will be randomly assigned to either take the mindfulness classes right away or join a waitlist…

This study tests whether using the Healthy Minds Program smartphone app can reduce depression symptoms in teenagers. About 200 teens aged 14-19 with elevated depression will use the app for 20 weeks. Researchers will track changes in depression and anxiety scores using standard s…

This study is testing a new program that combines counseling and faith to help African American adults with depression. Researchers will work with 12 church groups in Wisconsin to see if the program reduces depression symptoms. The goal is to create a helpful, evidence-based opti…

This study is testing a self-help workbook designed to help people in prison manage anxiety and depression. About 96 adults with moderate to severe symptoms will use the workbook for 8 weeks. Researchers will check if it is practical, acceptable, and helpful for improving mental …

This study looks at whether a 16-week resistance exercise program can reduce symptoms of major depression. Researchers will compare high-dose and low-dose exercise in 200 adults aged 18-65 with depression. The goal is to see if exercise improves mood and brain blood flow, offerin…

This study tests whether nicotine pouches or mini lozenges help people smoke fewer cigarettes. 300 adult smokers who don't plan to quit in the next month will use one of these products (or no product) for a week, then try to stop smoking for 3 weeks. Researchers will track how ma…

This study tests whether adding tranexamic acid (TXA) to hyaluronic acid (HA) facial filler can reduce bruising, swelling, and pain after injection. About 40 adults will receive filler with TXA on one side of the face and plain filler on the other, then rate their bruising. The g…

This early-stage study is testing whether a smartphone app called the Healthy Minds Program is practical and well-liked by people who have had suicidal thoughts in the past month. Fifty adults will use the app for 4 weeks and fill out questionnaires. The goal is to see if the app…

This study tests whether taking celecoxib (an anti-inflammatory) plus Tylenol can reduce the need for stronger opioid painkillers like oxycodone after a parotidectomy (salivary gland surgery). About 84 adults will take either celecoxib or a placebo, along with Tylenol, and use op…

This early-stage study tests whether adding psilocybin (the active ingredient in magic mushrooms) to standard buprenorphine/naloxone treatment is safe for people with opioid use disorder. Ten adults on stable medication will receive two doses of psilocybin while being monitored f…

This study follows 65 infants who had a stroke around birth to understand how their brains recover. Researchers will use safe brain scans (MRI), gentle magnetic stimulation (TMS), and movement tests at several visits from birth to age 2. The goal is to find signs of recovery that…

This study looks at whether letting parents read their child's medical notes on a bedside tablet helps them be more involved and catch safety problems. About 630 parents of hospitalized children under 12 will be randomly assigned to use the tool or receive usual care. Researchers…

This study looks at how to help prisons offer more medications for opioid use disorder (MOUD), like buprenorphine and methadone. Researchers will work with 120 prison sites to see which strategies work best. The goal is to improve health and reduce problems like drug-related inci…

This study tests whether an early learning program, usually done in person, works just as well when delivered virtually to families in rural areas. About 225 children aged 0-5 with a history of brain injury from lack of oxygen (HIE) or very premature birth will take part. Parents…

This study tests a new computer program that reads brain signals to tell if someone is conscious or not. Thirty healthy adults will have their brain activity recorded while awake and asleep. The goal is to see if a simpler, portable system can accurately detect consciousness. Thi…

This study uses special PET/CT scans to see how advanced prostate cancer becomes resistant to hormone-blocking drugs like enzalutamide or abiraterone. Researchers will track changes in cancer lesions over time in 25 men who are either starting or already on these therapies. The g…

This study looks at how asthma-related airway inflammation may affect brain function and mood. Researchers will compare brain scans, blood and sputum samples, and cognitive tests between 100 adults with severe asthma and healthy volunteers. The goal is to understand links between…

This study enrolls 422 schoolchildren and their families in Oregon to see if air samplers placed in homes can detect viruses that cause respiratory infections. Participants provide nasal swabs and report symptoms over 14 days. The goal is to learn how well air surveillance tracks…

This study looks at whether having a special hospital team that gets to know patients who are frequently hospitalized can improve their care. Researchers will compare patients assigned to this team with those getting usual care. The main goal is to see if these patients are more …

This study aims to understand why some children become carriers of group A strep bacteria without showing symptoms. Researchers will compare children with active strep throat to those who are carriers. The goal is to learn whether carriers need antibiotic treatment. The study inv…

This study looks at how babies' thinking skills grow over time, both in healthy infants and those who had a brain injury around birth. Researchers will use online games and parent questionnaires to measure attention, problem-solving, and language. The goal is to learn more about …

This study tests a newer radiation method (MRgART) against standard radiation (LINAC) for people with cancers in the chest area, like lung or esophageal cancer. The goal is to see if the newer method causes less damage to the heart. About 60 participants will receive radiation, M…

This study aims to see if it's possible to enroll and keep 30 children (ages 3-17) with PANS or PANDAS in a one-year observation. Researchers want to learn how often these conditions occur and how they change over time. No new treatments are being tested—just careful tracking of …

This study explores whether brain stimulation can help people quickly achieve a deep meditative state, normally requiring years of training. Twelve healthy adults who already meditate will wear a special cap to measure brain activity while receiving stimulation and performing gui…

This study looks at whether a computer program called pediatric eCART can help doctors quickly identify children in the hospital who are at risk of serious problems like heart failure or sepsis. Researchers will compare hospital records from before and after the tool was put into…

This study looks at how chemotherapy before surgery affects memory, attention, and other thinking skills in people with advanced ovarian cancer. Researchers will test 18 participants over about 10 months using simple mental tasks. The goal is to better understand cognitive change…

This study looks at how chronic lymphocytic leukemia (CLL) cells use nutrients like glucose and glutamine compared to normal cells. Researchers will give participants a special tracer (a safe, non-radioactive nutrient) and then measure how it's used by the cells. The goal is to f…

This study looks at whether metabolic syndrome harms artery function differently in young men versus women, and if a single 30-minute exercise session can temporarily improve it. Researchers will measure blood flow in the neck artery before and after exercise in 48 adults with an…

This study is testing a new AI tool that creates simple, patient-friendly summaries of radiology reports for people with cancer. Researchers want to see if these summaries help patients better understand their scan results and reduce the number of questions doctors get. About 2,0…

This study aims to find out if computer-based cognitive training can improve memory, attention, and problem-solving. Researchers will enroll 1,600 adults with normal vision and no known brain issues. Participants will complete up to 15 hours of brain games and thinking tasks over…

This study looks at a protein called PSMA in a specific type of advanced breast cancer (HER2-negative, AR-positive). Researchers want to see if PSMA levels can show why some cancers stop responding to hormone therapy. About 15 people will get a special PET scan to measure PSMA, a…

This study is testing whether a special type of ultrasound can safely check a baby's lung health before birth. Researchers will scan 16 pregnant women between 32 and 36 weeks of pregnancy. The goal is to see if the technique works, not to treat any condition.

This study looks at whether local anesthesia (numbing only the surgery area) works as well as general anesthesia (being fully asleep) for older adults having inguinal hernia repair. About 80 Veterans aged 60 and older will take part. The goal is to gather information to plan a la…