University Of Wisconsin, Madison

This study tests whether giving a lung medication (surfactant) mixed with an anti-inflammatory drug (budesonide) to extremely premature babies (born before 29 weeks) who are still on a breathing machine at 7-14 days old can safely prevent a serious lung condition called bronchopu…

This study tests whether combining two drugs—ASTX727 (a pill) and retifanlimab (given through a vein)—can shrink tumors or stop them from growing in people with advanced Merkel cell cancer that no longer responds to standard immunotherapy. About 31 adults will take the drugs for …

This study tests a text- and web-based tool called FamilyCHESS for people with moderate to severe opioid use disorder and a concerned loved one. The goal is to help patients begin and continue medication for opioid use disorder. About 338 participants will be enrolled, and the to…

This study tests an experimental stem cell transplant for children and young adults with blood diseases. Doctors will remove certain immune cells from donated stem cells before giving them to the patient, hoping the new cells will grow without causing severe graft-versus-host dis…

This study aims to find the best way to help Black adults stop smoking. It compares standard quitline services with more intensive, culturally tailored programs, including one with financial rewards. About 1,550 participants will be followed for 26 weeks to see which approach lea…

This study tests a new AI tool that lets primary care doctors screen for diabetic eye disease during regular visits. The goal is to see if this approach helps more patients get the eye follow-up they need, especially among Black and Hispanic groups. About 4,000 adults with diabet…

This study tests whether a mobile phone app can help African Americans with depression. Eight participants will attend six weekly 90-minute classes on their phone and fill out surveys. The goal is to see if the app reduces symptoms of depression and anxiety over four months.

This study will test whether taking a daily probiotic pill is safe and practical for older adults who have early Alzheimer's or are at risk for it. Researchers will enroll 40 people and follow them for up to one year. The main goal is to see if participants can stick with the sup…

This study tests a non-invasive technique called temporal interference stimulation to boost deep sleep in people with epilepsy. Researchers want to see if improving sleep can reduce seizures and improve mood and alertness. Up to 24 participants will receive both real and sham sti…

This study tests whether a well-being intervention can improve both emotional health and physical symptoms in adults with Irritable Bowel Syndrome (IBS). Researchers will measure changes in anger, anxiety, depression, self-esteem, empathy, hope, and IBS severity. About 150 partic…

This study looks at two mirror-image forms of methamphetamine: one found in decongestant sprays and a stronger one used for ADHD. Researchers will give these to 17 healthy adults and measure how the body processes them and how they affect thinking. The goal is to better understan…

This study uses a safe, non-invasive ultrasound test called Transcranial Doppler to measure blood flow in the brains of 125 children in the Pediatric Intensive Care Unit. Researchers want to see how brain blood flow changes during critical illness and whether those patterns relat…

This study tests whether a special MRI scan (CSE-MRI) can measure active bone marrow as accurately as a PET scan (FLT PET) in men with metastatic castration-resistant prostate cancer. Fifteen participants will receive both scans on the same day to compare results. The goal is to …

This study looks at whether adding a health education class and personal coaching to regular Special Olympics activities helps adults with intellectual or developmental disabilities get better healthcare. About 1,040 athletes and their care partners will take part. The goal is to…

This study tests a small device that attaches to a shoe to measure walking patterns in healthy adults aged 65 and older. Twenty participants will walk on a mat and climb stairs with and without the device to see how well it tracks speed and movement. The goal is to improve the de…

This study tests new MRI techniques to measure blood flow and tissue details in the liver. Researchers will scan 110 people, including healthy volunteers and those with chronic liver disease or fibrosis, to see if these scans can reliably detect liver damage. The goal is to devel…

This study looks at how metabolic syndrome (a cluster of conditions like high blood sugar and cholesterol) affects blood flow to the brain, and whether it does so more in women than men. Researchers will use MRI scans and exercise tests in 72 healthy adults and those with metabol…

This study looks at how well the body uses choline from a new dairy ingredient compared to eggs in women aged 51-70 who have gone through menopause. Participants will drink a chocolate-flavored drink with either the dairy ingredient or whole egg powder. The goal is to see if dair…

This study will compare two different machines that measure pressure and flow during swallowing in 25 healthy adults. The goal is to see how the devices differ and to standardize the measurements. This research does not treat any condition but aims to improve future diagnosis of …

This study looks at how psilocybin (a psychedelic drug) might improve mood and well-being. Researchers want to know if the 'trip' itself is key or if the drug works directly on the brain. Up to 120 healthy adults with low well-being will get psilocybin while awake or asleep, and …

This study tests a new journal tool that helps teens track and think about their social media use. Researchers will ask 50 participants aged 13-18 to try the journal and share their feedback. The goal is to see if teens find it useful and easy to use, so it can be shared with mor…

This study tests new computer software for MRI machines to see if it can make brain scans faster, quieter, and clearer. About 131 adults, including healthy volunteers and those scheduled for a routine brain MRI, will have one 60-minute scan using both standard and new methods. Re…

This study looks at whether learning about well-being can positively affect the thoughts and feelings of romantic couples. About 2000 adults in committed relationships will fill out online surveys about their mood and relationship satisfaction. The goal is to understand how knowl…

This study will test a new type of X-ray machine that takes clearer pictures during medical procedures like biopsies or injections. About 20 adults who are already scheduled for an image-guided procedure will have extra scans with this new system. The goal is to see if the new te…

This study looks at how often the common cold virus (rhinovirus) causes serious breathing problems in children that require hospital care. Researchers will follow 670 children, including a group of healthy toddlers and older kids, to track which virus types are circulating and ho…