University Of Wisconsin, Madison

This study tests whether giving anti-EGFR drugs (panitumumab or cetuximab) early in treatment can help control advanced colorectal cancer that has spread and cannot be removed by surgery. About 34 people with left-sided tumors will receive these targeted therapies to see if the c…

This study tests whether a low dose of the drug everolimus can safely improve signs of aging in people aged 55 to 80 who have insulin resistance or prediabetes. Participants take the drug daily or weekly for 24 weeks, and researchers measure changes in metabolism, heart function,…

This study tests whether high doses of vitamin C given through an IV can help people recover better after a liver transplant. About 90 adults having their first liver transplant will be randomly assigned to receive either vitamin C or a placebo (salt water) for 48 hours after sur…

This study tests a drug called sacituzumab govitecan in men with advanced prostate cancer that no longer responds to standard hormone therapy. The goal is to see if it can shrink tumors or slow the disease. About 31 participants will receive the drug, and researchers will measure…

This study tests a program called Connections that uses a smartphone app and peer mentors to support people with HIV who also have substance use disorders. The goal is to help them keep their virus under control and attend their clinic appointments. About 433 participants from 8 …

This study aimed to see if a living donor liver transplant, given after standard chemotherapy, could help people with colorectal cancer that spread to the liver and could not be removed by surgery. It planned to enroll 25 donor-recipient pairs (50 people total) and follow recipie…

This study tests whether adding a second DNA vaccine to a standard immunotherapy (pembrolizumab) can better control advanced prostate cancer that no longer responds to hormone therapy. About 60 adults with metastatic, castration-resistant prostate cancer will receive either one o…

This study is testing a new way of giving standard chemotherapy (R-CHOP) to older adults aged 75 and up with diffuse large B-cell lymphoma. The goal is to see if splitting the doses makes treatment easier to tolerate while still being effective. About 27 participants will receive…

This study tests a shorter course of high-dose radiation (hypofractionated radiotherapy) for people with soft tissue sarcoma that cannot be removed by surgery. The goal is to see if this approach can control the tumor for at least two years while causing fewer side effects. About…

This study tests a special donor cell infusion given after a stem cell transplant to help control high-risk blood cancers. The treatment removes certain immune cells to reduce side effects. The goal is to find a safe dose and see if it can prevent cancer from coming back.

This early-phase study tests a new drug (INCB081776) combined with standard radiation and an immunotherapy (pembrolizumab) in people with head and neck cancer that has spread or come back. The goal is to see if the combination is safe and helps control the disease. About 10 parti…

This study tests new MRI and ultrasound methods to measure liver fat in children aged 10-14, including those with obesity and healthy weight. The goal is to see if these non-invasive imaging techniques can reliably detect fatty liver disease (NAFLD) in kids. The study involves 24…

This study tests a technique where a fluorescent dye is used to make dead or inflamed tissue glow during burn surgery, helping surgeons decide exactly what to remove. About 100 adults with burn wounds will be enrolled, and their healing will be tracked for up to 24 days. The goal…

This study is testing a special lollipop-shaped device called CandyCollect to see if it can accurately detect strep throat in children ages 5-17. Instead of a traditional throat swab, kids suck on the lollipop, which collects saliva for testing. The goal is to make strep testing …

This study tests whether using artificial intelligence (AI) to screen for diabetic eye disease during regular primary care visits helps more people get the eye exams they need. About 1,700 adults with diabetes who haven't had an eye exam in the past year will take part. The goal …

This study tests a program called RESTORE that helps nurses redesign their work to reduce stress and burnout. About 470 nurses will be interviewed and complete surveys about their job demands, resources, and well-being. The goal is to see if changing how work is organized can imp…

This pilot study planned to give 25 adults a medication called lorazepam before getting an IUD placed, to see if it helped with pain and anxiety. Participants would rate their pain and anxiety on simple 0-to-10 scales. The study was withdrawn before enrolling anyone, so no result…

This study tests whether gently removing the top layer of skin (dermabrasion) during Mohs surgery helps scars heal more smoothly. About 30 adults having facial or neck surgery will have half their wound treated with dermabrasion and the other half not, so each person acts as thei…

This study looks at whether a special mindfulness class (Mindfulness-Based Childbirth and Parenting) can help pregnant women with high anxiety feel better. Sixty pregnant women will be randomly assigned to either the mindfulness class or a standard childbirth class. Researchers w…

This study tests whether a short video and a 3-week text messaging program can help people who have recently experienced sexual assault. The goal is to see if these tools can reduce mental health problems like PTSD and prevent misuse of opioids and other substances. About 394 adu…

This study looks at whether using the Leva Pelvic Health System for 8 weeks is as good as using it for 16 weeks to help women with fecal incontinence. About 38 women will use the device and fill out surveys. The goal is to find the shortest effective treatment time.

This early-stage study tests whether injecting a person's own bone marrow stem cells into their salivary glands can safely relieve severe dry mouth caused by radiation therapy for head and neck cancer. About 23 adults who finished radiation at least two years ago and have no acti…

This study looks at whether an 8-session nutrition education program is practical and well-liked by patients in a general medicine clinic. The program teaches eating more fiber-rich foods like fruits, vegetables, and whole grains to help manage diabetes and support weight loss. A…

This early-stage study aimed to see if ketamine-assisted psychotherapy is safe and doable for teenagers aged 15-17 with severe PTSD. Five teens were to receive three ketamine doses along with therapy sessions over six weeks, plus sleep monitoring. The study is currently suspended…

This study looks at whether an 8-week mindfulness program, done remotely via an app, can improve mental health and recovery in people who had ACL knee surgery. About 47 participants aged 16-40 will be randomly assigned to mindfulness or standard care. The goal is to reduce anxiet…

This early-phase study tests whether a person's own bone marrow stem cells can safely improve dry mouth caused by past radiation for head and neck cancer. Six to twelve participants receive an injection of their own cells and are monitored for side effects and changes in saliva p…

This study looks at vitamin A levels in 90 adults with vocal fold leukoplakia, a condition that causes white patches on the vocal cords. Researchers want to see if vitamin A status differs between people with and without precancerous changes. Participants provide blood and tissue…

This study looks at whether air samplers placed in homes can detect viruses that cause colds and flu, and how that compares to standard nasal swabs. About 422 students and their families will participate. The goal is to better understand how respiratory viruses spread through hou…

This study looks at blood samples from 20 adults with melanoma or other skin cancers to see if certain markers in the blood can predict how well treatment works or how long someone lives. Researchers will compare these markers to standard measures like tumor response and survival…

This study looks at a training program called FCS that teaches surgeons how to communicate better with patients and teams. About 600 surgeons and trainees will take part to see if the training helps them feel more confident and if it can be used in many hospitals. The goal is to …

This study tests whether a new type of MRI can predict thinking and memory problems in people with multiple sclerosis (MS). Researchers will scan the brains of 75 adults with MS and compare the images to their performance on thinking tests. The goal is to find a better way to det…

This study tests a program called I-SITE that helps rural health systems use teleophthalmology (eye exams via photos) to increase diabetic eye screening rates. Up to 10 rural health systems and 10,000 patients with diabetes will take part for up to 48 months. The goal is to see i…

This study looks at whether special scans and genetic tests can help predict how well high-risk prostate cancer responds to hormone therapy and radiation. About 30 participants will have imaging and tumor gene analysis before and during treatment. The goal is to find early signs …

This study looks at how adults at risk for Alzheimer's disease react after learning their brain scan results for amyloid and tau proteins. Researchers will track changes in distress, stigma, quality of life, and future planning over time. The goal is to understand the emotional a…

This study explores a care approach called a time-limited trial (TLT) for ICU patients who need a breathing machine. In a TLT, the medical team and family agree to try treatments for a set period, then review progress. The goal is to learn the best way to use TLTs to reduce time …

This study trains police officers and first responders to better communicate with people who have aphasia, a condition that affects speech and understanding. 75 participants from the Madison Police Department will take part for up to 6 months. The goal is to see if training impro…

This study looks at how Salvation Army staff can help people who smoke learn about and use free services to quit. About 233 adults who use Salvation Army services will take part. Researchers will track how many people are referred to the Wisconsin Tobacco Quit Line and how many a…

This study looks at how brain blood flow and the autonomic nervous system work in veterans who served in the Gulf War (1990-1992) and have Gulf War Illness. Researchers will measure changes in brain blood flow and nerve activity using ultrasound, MRI, and a breathing test. The go…

This study looks at how a protein called AXL in head and neck tumors responds to a combination of two drugs, imatinib and cetuximab, given before standard treatment. About 15 adults with head and neck cancer will receive the drugs for a short time between diagnosis and surgery or…

This study compares two methods of training surgeons to have clearer, more supportive conversations with older patients about surgery. About 60 surgeons and 660 patients will take part. The goal is to see if automated computer feedback can work as well as training from a human sp…

This study looks at whether a new ankle brace changes how athletes run and cut. Researchers will test 30 athletes on a treadmill and during shuttle runs, asking them to rate comfort, stability, and movement. The goal is to see if the brace works well without hurting performance.

This long-term study follows 1,545 adults to understand how sleep-disordered breathing (like sleep apnea) develops and affects health over time. Researchers use overnight sleep tests and questionnaires to track sleep problems, and check for links to heart disease, stroke, and moo…

This study aims to learn more about vascular stains (a type of birthmark) by using a special imaging technique called optical coherence tomography (OCT) and genetic testing. About 73 people with these birthmarks will have their blood vessels measured and their tissue genes analyz…

This study looks at whether a program called I-SITE can help more people with diabetes get their eyes checked using telemedicine (remote eye photos). Over 12,000 patients from urban health systems are included. The goal is to see if this approach increases screening rates and hel…

This study tests a tool called Best Case/Worst Case-ICU to help doctors talk with families about treatment options for older adults (50+) with serious injuries in the ICU. Researchers will follow about 4,500 patients, 1,500 family members, and 1,600 doctors across 8 hospitals to …

This study looks at different ways to help people keep their dental appointments in clinics that serve low-income and uninsured patients. Researchers will compare reminder messages, walk-in options, and better communication to see which works best. About 48 clinic staff members w…

This study follows 499 children from birth to age 6-7 to understand how early-life factors like allergens, pollution, and microbes may lead to asthma and allergies. Parents with asthma or hay fever are included. No treatments or changes are made—just observation to uncover root c…

This study looks at whether different types of outreach from navigators—trained helpers who assist with the renewal process—can increase the number of people who keep their Medicaid coverage. Over 119,000 Wisconsin residents on fee-for-service Medicaid are included. The goal is t…

This study looks at how a special clinic helps older adults get ready for major abdominal surgery. Researchers will watch and talk to doctors, staff, and patients to understand what works well and what could be better. The goal is to create a clear plan that other hospitals can u…

This study aimed to understand how temperature, visuals, and sounds together influence comfort and body responses like heart rate and skin temperature. Healthy adults aged 18-40 would watch videos in two different climate-controlled rooms and report how they felt. The study was w…