University Of Wisconsin, Madison

This study tests a smartphone-based tool called FamilyCHESS, designed to help people with moderate to severe opioid use disorder begin and continue medication treatment. The tool also involves a concerned family member or friend who provides support. Researchers will compare outc…

This study tests whether combining two drugs—ASTX727 (a pill) and retifanlimab (given through a vein)—can shrink tumors and control advanced Merkel cell cancer in people whose disease has worsened after standard immunotherapy. About 31 adults with stage III or IV Merkel cell canc…

This study tests whether giving a special lung medicine (surfactant mixed with budesonide) to extremely premature babies who are still on a breathing machine at 7-14 days old is safe and can help prevent a serious lung condition called bronchopulmonary dysplasia. About 24 babies …

This study tests an experimental stem cell transplant for children and young adults with blood diseases. Doctors will remove certain immune cells from donated stem cells before giving them to the patient, hoping the new cells will grow without causing severe graft-versus-host dis…

This study aims to find the best way to help Black adults stop smoking. It compares standard quitline services with more intensive, culturally tailored programs, including one with financial rewards. About 1,550 participants will be followed for 26 weeks to see which approach lea…

This study tests a new AI tool that lets primary care doctors screen for diabetic eye disease during regular visits. The goal is to see if this approach helps more patients get the eye follow-up they need, especially among Black and Hispanic groups. About 4,000 adults with diabet…

This study tests whether a well-being intervention can improve both emotional health and physical symptoms in adults with Irritable Bowel Syndrome (IBS). Researchers will measure changes in anger, anxiety, depression, self-esteem, empathy, hope, and IBS severity. About 150 partic…

This pilot study tests whether a mobile phone app can effectively deliver depression treatment to African Americans. Eight participants will attend six weekly 90-minute cognitive behavioral classes via the app and complete surveys over four months. The goal is to see if symptoms …

This study tests a non-invasive technique called temporal interference stimulation to boost deep sleep in people with epilepsy. Researchers will compare 4 nights of real stimulation to 4 nights of sham (fake) stimulation in up to 16 patients. The goal is to see if better sleep ca…

This study will test whether taking a daily probiotic pill is safe and practical for older adults who have early Alzheimer's or are at risk for it. Researchers will enroll 40 people and follow them for up to one year. The main goal is to see if participants can stick with the sup…

This pilot study will test a wearable device called OptiGait that attaches to a shoe to measure walking speed and natural gait. Twenty healthy adults aged 65 and older will walk with and without the device to see if it accurately captures movement. The goal is to refine the devic…

This study will test whether a special MRI scan (CSE-MRI) can accurately measure active bone marrow in men with metastatic prostate cancer, compared to a standard PET scan using a radioactive tracer (FLT). Fifteen participants will receive both scans at the same time using a comb…

This study will use a non-invasive ultrasound test called Transcranial Doppler to measure blood flow in the brains of 125 children in the Pediatric Intensive Care Unit. Researchers want to see how brain blood flow changes during critical illness and whether those patterns relate …

This study will give 17 healthy adults three different versions of methamphetamine to see how the body processes each one. Meth comes in two mirror-image forms: S-meth, a strong stimulant used for ADHD, and R-meth, a weaker form found in some nasal sprays. Researchers will measur…

This study will give psilocybin to 120 healthy adults with low well-being, either while awake or asleep, to see if the psychedelic experience is needed for mood benefits. Participants will also receive a placebo or clonidine for comparison. The goal is to understand how psilocybi…

This study tests new computer software for brain MRI scans to see if it can make them faster, quieter, and clearer. About 131 adults, including healthy volunteers and patients already scheduled for a brain MRI, will have one 60-minute scan session. Researchers will compare standa…

This study tests whether adding a health education and coaching program to Special Olympics activities helps adults with intellectual or developmental disabilities get better healthcare. About 1,040 athletes and their care partners will take part. The goal is to see if this extra…

This study tests a new journal designed to help teens track their social media use. Researchers will ask 50 participants aged 13-18 to use the journal and give feedback on how easy and helpful it is. The goal is to see if this tool is practical and acceptable for wider use.

This study looks at whether learning about well-being can improve how romantic partners think and feel. About 2,000 couples with mild depression symptoms will take online surveys about their emotions and relationship satisfaction. The goal is to see if gaining knowledge about wel…

This study will compare two different systems that measure pressure and flow during swallowing in 25 healthy adults. The goal is to see how the devices differ and to standardize the measurements. This research does not treat any condition but will help improve future diagnosis an…

This study aims to find out how often rhinovirus (the virus behind many common colds) causes serious breathing problems that require hospital care in children. Researchers will follow 120 young children at home for 3 years and study 450 hospitalized infants and children, plus 100…

This study tests new MRI techniques to measure blood flow and tissue details in the liver. Researchers will scan 110 people, including healthy volunteers and those with chronic liver disease or fibrosis, to see if these scans can reliably detect liver damage. The goal is to devel…

This study looks at how metabolic syndrome (a cluster of conditions like high blood sugar and cholesterol) affects blood flow to the brain, and whether it does so more in women than men. Researchers will use MRI scans and exercise tests in 72 healthy adults and those with metabol…

This study looks at how well the body uses choline from a new dairy ingredient compared to eggs in women aged 51-70 who have gone through menopause. Participants will drink a chocolate-flavored drink with either the dairy ingredient or whole egg powder. The goal is to see if dair…

This study will test a new type of X-ray machine that takes clearer pictures during medical procedures like biopsies or injections. About 20 adults who are already scheduled for an image-guided procedure will have extra scans with this new system. The goal is to see if the new te…