1,000 eye photos could teach AI to spot blindness early
NCT ID NCT06924021
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is collecting eye images from 1,000 adults aged 50 and older, with or without age-related macular degeneration (AMD), from up to 25 countries. The goal is to create a high-quality, diverse dataset that researchers can use to train artificial intelligence (AI) to screen for AMD. Participants will provide images of their eyes but will not receive any treatment as part of this study.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 1,000 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2025
- Expected to finish
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Nov 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Approximately 1000 participants from up to 25 sites in the United States, Europe, Asia, South America, Africa, and Australia will be enrolled and balanced by age, sex, and AMD level (worse eye selected as study eye). Every region listed above may not be represented and additional regions/countries not listed above may be included.
- Ages
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50 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Participants greater than or equal to 50 years of age at time of signing Informed Consent Form * Willing to comply with all study procedures and sign the Informed Consent Form (ICF) * Individuals with normal healthy eyes or diagnosed with any stage of Age-Related Macular Degeneration (treatment naïve patients with early, intermediate, or late AMD). The diagnosis and eligibility review will be confirmed by Central Reading Center. Exclusion Criteria: * Therapeutic treatment for any type of AMD, in either eye. Supplements, such as AREDS2 formula, are allowed. * Unable to acquire adequate quality images, as evaluated by the Central Reading Center * Severe vision loss requiring urgent surgery * Contraindicated for acquiring retinal images due to narrow anterior chamber angles or hypersensitivity to light * A systemic or ocular condition that in the opinion of the Investigator would preclude participation in the study * Unwilling to sign informed consent form * Currently or previously enrolled in an interventional AMD clinical trial
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
14 sites in 7 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Adelaide Eye and Retina Centre
NOT_YET_RECRUITINGAdelaide, 5000, Australia
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Aga Khan University
RECRUITINGKarachi, 74800, Pakistan
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Aravind Eye Hospital
RECRUITINGChennai, Tamil Nadu, 641014, India
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Bergstrom Eye Research LLC
RECRUITINGFargo, North Dakota, 58103, United States
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Centre Hospialier Intercommunal de Paradis (Centre Monticelli Paradis)
NOT_YET_RECRUITINGMarseille, 13008, France
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Charles Research Center
NOT_YET_RECRUITINGBuenos Aires, Argentina
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Erie Retina Research
RECRUITINGErie, Pennsylvania, 16507, United States
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Retina Consultants of Texas (Houston)
RECRUITINGThe Woodlands, Texas, 77384, United States
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Retina Foundation of the Southwest
RECRUITINGDallas, Texas, 75231, United States
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Sankara Nethralaya, Medical Research Foundation
RECRUITINGChennai, Tamil Nadu, 600006, India
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University Station Eye Care Clinic
RECRUITINGMadison, Wisconsin, 53705, United States
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University of Bonn - Department of Ophthalmology
NOT_YET_RECRUITINGBonn, 53127, Germany
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University of Utah - John A. Moran Eye Center
RECRUITINGSalt Lake City, Utah, 84132, United States
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Valley Retina Institute
RECRUITINGMcAllen, Texas, 78503, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Could years of eye injections weigh down the upper eyelid?
- Can blocking rogue immune cells stop a leading cause of blindness?
- A window into the eye: could functional tests predict macular degeneration progression?
- Can a VR maze reveal hidden vision loss in macular degeneration?
- Can a new eye injection save vision in wet AMD?
- A new eye camera may spot stressed cells before vision loss begins