AGE-RELATED MACULAR DEGENERATION

This study is for people in Japan aged 40 and older with geographic atrophy, a form of age-related macular degeneration that causes vision loss. The goal is to check the safety of a monthly eye injection called ASP3021 over 12 months. About 20 participants will receive the inject…

This early-phase study tests a stem cell therapy called ASP7317 for people with geographic atrophy, the advanced form of dry age-related macular degeneration that causes central vision loss. The treatment involves injecting special cells under the retina to replace damaged ones. …

This study tests a new drug called VOY-101 in 60 people aged 60 and older with advanced dry age-related macular degeneration (AMD), a condition that causes blind spots. The goal is to see if the drug is safe and can slow the growth of these spots and preserve vision. Participants…

This study tests a new medicine called ABBV-6628 for people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes vision loss. About 66 adults aged 50 and older will receive eye injections of ABBV-6628 or an approved treatment (SYFOVRE) to …

This study tests a new medicine called tiespectus (also known as MK-8748 or EYE201) for wet age-related macular degeneration (AMD), a leading cause of vision loss. About 960 people with untreated wet AMD will receive either tiespectus or the standard treatment aflibercept via eye…

This study tests whether high-dose atorvastatin (a cholesterol-lowering drug) can improve night vision in people with intermediate age-related macular degeneration (AMD). About 21 participants will take the drug and have their dark adaptation (how well eyes adjust to dim light) m…

This study is testing a personalized treat-and-extend approach using faricimab for people newly diagnosed with polypoidal choroidal vasculopathy (PCV), a form of age-related macular degeneration. The goal is to see if this regimen can control the disease while allowing longer int…

This study tests whether taking krill oil supplements for 3 months can reduce harmful deposits (drusen) in the eyes of people with early or intermediate dry age-related macular degeneration (AMD). 24 adults will receive either krill oil capsules or a placebo daily. The goal is to…

This study tests a new medicine called tiespectus (EYE201) against a standard treatment (aflibercept) for wet age-related macular degeneration, a leading cause of vision loss. About 960 adults with untreated wet AMD will receive eye injections and be followed for a year to see if…

This study tests a device that delivers tiny electrical pulses through the eyelid to treat dry age-related macular degeneration (AMD), a leading cause of vision loss. About 100 people with intermediate to advanced dry AMD will receive either real or sham (inactive) treatments ove…

This study tests a small telescope implant for people with end-stage age-related macular degeneration (AMD) who have lost central vision. The device is implanted in one eye to magnify images and improve sight. Researchers will follow 76 participants for 12 months to check safety …

This study looks at how well a biosimilar drug called Yesafili (MY-1701P) works for people with wet age-related macular degeneration (AMD), a condition that causes vision loss. Researchers will track 54 patients to see if the drug improves vision and reduces fluid buildup in the …

This study tests a new way to detect age-related macular degeneration (AMD) before it causes vision loss. Researchers will use special patterns of light, based on quantum science, to see if the eyes of people with early AMD react differently than healthy eyes. The goal is to catc…

This early-phase study tests whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve vision in people with retinal degeneration. Researchers believe it may reduce harmful activity in the retina. The study involves 15 adults with inherited retinal disease …

This study tests whether people with central vision loss from age-related macular degeneration can read faster and more accurately when missing text is remapped to other parts of their visual field. About 108 participants will try different remapping techniques while their readin…

This study tests whether teaching people with age-related macular degeneration, diabetic retinopathy, or glaucoma simple strategies—like using brighter lights, larger print, or smartphone apps—can help them manage their medications more safely and independently. About 50 particip…

This study is for people aged 50 and older with early signs of age-related macular degeneration (AMD), a common eye condition that can lead to vision loss. Researchers want to better understand how early damage spots in the retina grow over time and how they affect vision and qua…

This study looks at fluid from the eyes of people with wet age-related macular degeneration (AMD) to understand why 20-40% of patients do not improve much with standard anti-VEGF injections. Researchers will compare samples from good and poor responders over 24 weeks. The goal is…

This study looks at what 'visual frailty' means for people aged 60 and older who have age-related macular degeneration (AMD). Researchers will measure vision, reading ability, daily function, mental health, and other health conditions to create a new assessment tool. The goal is …

This study collects blood, tissue, and health information from people with and without retinal diseases like age-related macular degeneration and diabetic retinopathy. The goal is to create a research database to help scientists understand why some people get eye diseases and oth…

This study looks at whether taking a daily supplement of lutein, zeaxanthin, and fish oil for six months can improve thinking skills, eye health, and bone density in healthy adults. Researchers will compare people who take the supplement to those who take a placebo. The goal is t…

This study will collect eye images from 1000 people aged 50 and older, both with healthy eyes and with age-related macular degeneration (AMD), from up to 25 countries. The goal is to create a high-quality dataset that researchers can use to develop artificial intelligence (AI) to…