AGE-RELATED MACULAR DEGENERATION

This study tested an experimental drug called ALK-001 in people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes blind spots. About 200 participants received the drug and 100 received a placebo. The main goal was to see if ALK-001 coul…

This study tested a drug called carbidopa-levodopa, normally used for Parkinson's disease, in 20 people with wet age-related macular degeneration (AMD). The goal was to see if the drug is safe and can improve vision and reduce fluid buildup in the retina. Participants had not rec…

This study tested whether the antibiotic minocycline, taken as a pill twice daily for 3 years, could safely slow the growth of geographic atrophy—an advanced form of age-related macular degeneration that causes blind spots. Thirty-seven adults aged 55 and older with geographic at…

This study tested two different dosing schedules of the drug brolucizumab in 52 adults aged 50 and older with age-related macular degeneration (AMD) who had not responded well to previous treatment. The goal was to see which schedule better maintains or improves vision over 52 we…

This study checks the long-term safety of an eye injection called avacincaptad pegol for people with geographic atrophy, a form of advanced age-related macular degeneration. It includes 278 adults aged 50 and older who completed a previous study of the same drug. The main goal is…

This study tested whether a drug used for Parkinson's disease (carbidopa-levodopa) could help people with wet age-related macular degeneration (AMD). The drug may protect the retina and reduce the need for frequent eye injections. 35 participants who were already receiving standa…

This study tested a robotic arm that holds a tiny needle steady while a surgeon injects a clot-busting medicine (tPA) under the retina. The goal was to see if the robot could help place the needle correctly and keep it still for up to 3 minutes. Twenty people with bleeding under …

This study tested whether regular eye injections of a drug called aflibercept could prevent the 'wet' form of age-related macular degeneration (AMD) in people at high risk. 128 participants received either the drug or a sham injection. The goal was to see if the drug could stop t…

This study tested whether a steroid eye drop called loteprednol can reduce pain after eye injections for age-related macular degeneration. 64 patients received either loteprednol or artificial tears after their injection and reported pain levels over one week. The goal is to find…

This study followed 20 adults aged 55 and older with geographic atrophy, an advanced form of age-related macular degeneration that causes central vision loss. Researchers measured how the area of damage in the eye changed over nearly 4 years using special eye images. The goal was…

This study looked at 60 people with geographic atrophy, an advanced form of dry age-related macular degeneration that causes permanent vision loss. Researchers reviewed past eye exams and scans to see how vision loss relates to changes in the retina. No new treatments were tested…

This study looked at 100 people with age-related macular degeneration to measure certain proteins in their eye fluid. The goal was to understand why about 37% of patients do not respond well to standard anti-VEGF injections. Researchers hope this knowledge will help predict treat…

This study looked at whether special eye scans (SDOCT) can predict vision loss and worsening of age-related macular degeneration (AMD) in people at moderate to high risk. Researchers followed 470 adults aged 50-85 who were already in a larger AMD trial. They measured changes in t…

This study looked at whether giving people with age-related macular degeneration (AMD) personalized risk information, including genetic testing, along with coaching, helps them make healthier lifestyle changes. 150 participants with early or intermediate AMD took part. The goal w…

This study looked at 68 adults with wet age-related macular degeneration (AMD) to see if a newer type of eye scan (OCT angiography) changes how doctors decide when to give injections, compared to the standard scan (OCT B-scan). The goal was to see if the newer scan helps keep vis…

This study collected eye images from 1,000 people with intermediate age-related macular degeneration (AMD) to create a database. Researchers will analyze these images to find patterns that predict if and when the disease will worsen to advanced stages. The goal is to improve earl…

This study looked at whether telling healthy people their genetic risk for age-related macular degeneration (AMD) would encourage them to eat more foods rich in carotenoids, which are good for eye health. About 80 Caucasian adults aged 18 to 64 without AMD took part. Researchers …

This study looked at 556 people to understand why some with early age-related macular degeneration (AMD) have trouble seeing in the dark. Researchers used advanced eye imaging to map how changes in the retina affect night vision recovery. The goal is to find better ways to measur…

This study followed 26 adults aged 55 and older with early age-related macular degeneration (AMD) or healthy eyes for up to 5 years. Researchers used eye exams, imaging, and vision tests to track changes in the retina and understand how the disease progresses. The goal was to lea…