Night vision test may spot early eye disease
NCT ID NCT04112667
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study looked at 556 people to understand how night vision problems are connected to early age-related macular degeneration (AMD). Participants took vision tests and had detailed eye imaging. The goal was to find reliable markers that could help design future treatments for AMD.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help identify reliable markers for early AMD, paving the way for future treatments.
- What could go wrong
- This is an observational study, not a treatment trial. It may not directly lead to new therapies, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
556 people
The number who actually took part.
- Started
-
Oct 2019
- Finished
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Oct 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
group 1 is \>=60 years old with normal macular health group 2 is \>=60 years old with early AMD group 3 is 20-30 years old are Young Normals
- Ages
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20 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: For those in Normal Macular Health or Early AMD: aged ≥ 60 years; either have normal macular health in both eyes at baseline or have early AMD in one eye For Young Normals: aged 20-30 years old; normal macular health in both eyes. Exclusion Criteria: Exclusion for those in normal macular health are: * ANY EYE CONDITION OR DISEASE IN EITHER EITHER (OTHER THAN EARLY CATARACT) THAT CAN IMPAIR VISION INCLUDING: * diabetic retinopathy * glaucoma * ocular hypertension * history of retinal diseases (e.g., retinal vein occlusion, retinal degenerations) * optic neuritis * corneal disease * previous ocular trauma or surgery * REFRACTIVE ERROR \>- 6 DIOPTERS * NEUROLOGICAL CONDITIONS THAT CAN IMPAIR VISION OR JUDGEMENT INCLUDING: * multiple sclerosis * Parkinson disease * stroke * Alzheimer disease * seizure disorders * brain tumor * traumatic brain injury * PSYCHIATRIC DISORDERS THAT COULD IMPAIR THE ABILITY: * to follow simple directions * answer questions about health and functioning * or to provide informed consent * DIABETES * ANY MEDICAL CONDITION THAT CAUSES SIGNIFICANT FRALITY OR IS BELIEVED TO BE TERMINAL. Exclusion criteria for the early AMD group: These are identical to those described above, except that it is acceptable for participants to have early AMD (AREDS 2-4) in one eye and be AREDS grade 1 or any stage of AMD in the fellow eye. Exclusion for Young Normals: * ANY EYE CONDITION OR DISEASE IN EITHER EYE (OTHER THAN EARLY CATARACT) THAT CAN IMPAIR VISION INCLUDING: * diabetic retinopathy * glaucoma * ocular hypertension * history of retinal diseases (e.g., retinal vein occlusion, retinal degenerations) * optic neuritis, corneal disease * previous ocular trauma or surgery * RERACTIVE ERROR \>=6 DIOPTORS * NEUROLOGICAL CONDITIONS THAT CAN IMPAIR VISION OR JUDGEMENT INCLUDING: * multiple sclerosis * Parkinson disease * stroke * Alzheimer disease * seizure disorders * brain tumor * traumatic brain injury * PSYCHIATRIC DISORDERS THAT COULD IMPAIR THE ABILITY TO: * follow simple directions * answer questions about health and functioning * or to provide informed consent * DIABETES * ANY MEDICAL CONDITION THAT CAUSES SIGNIFICANT FRAILTY OR IS BELIEVED TO BE TERMINAL.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
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