Eye imaging study aims to predict who will lose sight from AMD
NCT ID NCT05698316
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed study collected eye images from 1,000 people with intermediate age-related macular degeneration (AMD) to create a detailed database. Researchers will analyze these images to find signs that predict whether the disease will worsen to advanced stages. The goal is to improve early detection and monitoring, not to test a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors predict which patients with intermediate AMD will develop vision loss, enabling earlier monitoring or treatment.
- What could go wrong
- This is an observational study that builds a database, not a treatment trial. It may not lead to immediate clinical changes, and the predictive models need further validation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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1,000 people
The number who actually took part.
- Started
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May 2023
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patient with Age-related macular degeneration (AMD)
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Each dataset per patient should have one eye as the study eye with: * Intermediate AMD with no atrophy and no subretinal drusenoid deposits * Intermediate AMD with no atrophy with subretinal drusenoid deposits * Intermediate AMD with early atrophy (iRORA) with no Subretinal drusenoid deposits * Intermediate AMD with early atrophy (iRORA) with Subretinal drusenoid deposits * Intermediate AMD with evidence of cRORA Non-study eye images will not be exported but information about the status of the macula should be added using the following options: * Established Geographic Atrophy (cRORA) * Exudative AMD (presence of MNV) * Early AMD * Healthy macula Exclusion Criteria: * Both eyes have exudative AMD or geographic atrophy at baseline. * Co-existent ocular disease: Any other ocular condition that, in the investigator's opinion, might affect or alter visual acuity during the study. * Any patient who has opted out of their information being used for research nationally or locally at any Member Site.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AIBILI-CEC (AIBILI- Clinical Trials Centre)
Coimbra, Portugal
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Clinical Eye Research Centre - St. Paul's Eye Unit, Royal Liverpool University Hospital
Liverpool, United Kingdom
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Clinical Trial Unit, Dep. Ophth., Gloucestershire Hospitals NHS Foundation Trust
Cheltenham, United Kingdom
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Clínica Oftalmológica AIKEN / Fundación Aiken de la Comunitat Valenciana
Valencia, Spain
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Department of Ophthalmology Justus/Liebig/University/Giessen
Giesen, Germany
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Department of Ophthalmology Porto Medical School / Hospital S. João
Porto, Portugal
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Department of Ophthalmology Radboud University Medical Centre Nijmegen
Nijmegen, Netherlands
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Department of Ophthalmology St. Franziskus/Hospital Münster
Münster, Germany
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Department of Ophthalmology University of Bonn
Bonn, Germany
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Department of Ophthalmology University of Freiburg
Freiburg im Breisgau, Germany
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Department of Ophthalmology University of Muenster Medical Center
Münster, Germany
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Department of Ophthalmology University of Udine
Udine, Italy
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Department of Ophthalmology, University Hospital, Nantes
Nantes, France
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Espaço Médico de Coimbra
Coimbra, Portugal
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Eye Clinic Sulzbach, Knappschaft Hospital Saar
Sulzbach, Germany
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Eye Unit, University Hospital Maggiore della Carità
Novara, Italy
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Institut Català de Retina (ICR), Clinical Trial Unit
Barcelona, Spain
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Institut de la Màcula Centro Médico Teknon
Barcelona, Spain
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Instituto de Oftalmologia Dr. Gama Pinto
Lisbon, Portugal
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Medical Retina Service, Operative Unit Ophthalmology / MultiMedica Spa (IRCCSMM)
Milan, Italy
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NIHR Moorfields Clinical Research Facility, Moorfields Eye Hospital, NHS Foundation Trust
London, United Kingdom
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Royal Victoria Eye and Ear Research Foundation
Dublin, Ireland
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Swiss Visio Retina Research Center, Swiss Visio Montchoisi
Lausanne, Switzerland
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University Hospital Basel, University Eye Clinic, Basel
Basel, Switzerland
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Valles Ophthalmology Research, S.L.
Barcelona, Spain
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