Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New eye injection could change treatment for wet AMD

NCT ID NCT07496567

Disease control Sponsor: EyeBiotech Ltd. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Aug 07, 2026 · Updated 7 times

Summary

This study tests a new drug called tiespectus (MK-8748) against the current standard treatment, aflibercept, for people with wet age-related macular degeneration (AMD). About 960 participants will receive injections into the eye and be followed for a year to see if tiespectus can improve vision as well as or better than aflibercept. The goal is to find a new option for those who don't respond well to existing treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
tiespectus (also called MK-8748 or EYE201)
What this could lead to
If it works, this could offer a new treatment option for wet age-related macular degeneration, potentially helping people maintain or improve their vision.
What could go wrong
This is an early-to-mid stage trial, so the drug may not work better than the current standard treatment. There are also risks from the eye injection itself, such as infection or inflammation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 960 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

The main inclusion criteria include but are not limited to the following: * Has treatment naive choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) including subfoveal, juxtafoveal and extrafoveal lesions or retinal angiomatous proliferations (RAP) and polypoidal choroidal vascularization (PCV) lesions in at least one eye (study eye) * The diagnosis of neovascular age-related macular degeneration (NVAMD) must have been made within 21 days prior to starting study treatment The main exclusion criteria include but are not limited to the following * Has uncontrolled blood pressure at screening * History of any prior macular laser photocoagulation in the study eye * History of uveitis in either eye * History of cataract surgery, minimally invasive glaucoma surgery, or Yttrium-Aluminium Garnet (Yag) laser capsulotomy in the study eye within 90 days before entering the study * Has uncontrolled glaucoma in the study eye * Active retinal disease other than the condition under investigation in the study eye * Has previously received anti- vascular endothelial growth factor (VEGF) therapy or other intravitreal (IVT) therapy in the study eye

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Age-related macular degeneration are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

age-related macular degeneration choroidal neovascularization macular degeneration wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Age-related macular degeneration Choroidal neovascularization Macular degeneration Wet macular degeneration

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    71 sites in 9 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • AIBILI Azinhaga de Santa Comba

    RECRUITING

    Coimbra, 3000-548, Portugal

  • Asheville Eye Associates, Retina Division (Site 077)

    RECRUITING

    Asheville, North Carolina, 28803, United States

  • Associated Retina Consultants - Gilbert

    RECRUITING

    Gilbert, Arizona, 85259, United States

  • Astra Clinic.s.r.o.

    RECRUITING

    Prague, 184 00, Czechia

  • Austin Retina Associates

    RECRUITING

    Round Rock, Texas, 78681, United States

  • Austin Retina Associates

    RECRUITING

    San Marcos, Texas, 78666, United States

  • Axon Clinical, s.r.o. (Site 400)

    RECRUITING

    Prague, 150 00, Czechia

  • Budapest Retina Associates

    RECRUITING

    Budapest, 1133, Hungary

  • Butchertown Clinical Trials

    RECRUITING

    Louisville, Kentucky, 40206, United States

  • Cascade Medical Research Institute, LLC

    RECRUITING

    Springfield, Oregon, 97477, United States

  • Center for Retina and Macular Disease (Site 062)

    RECRUITING

    Winter Haven, Florida, 33880, United States

  • Centre Ophtalmologique Saint Exupéry

    RECRUITING

    Saint-Cyr-sur-Loire, 37540, France

  • Centre d'Ophtalmologie Paradis-Monticelli

    RECRUITING

    Marseille, 13008, France

  • Charleston Neuroscience Institute

    RECRUITING

    Ladson, South Carolina, 29456, United States

  • Charleston Neuroscience Institute (Site 034)

    RECRUITING

    Beaufort, South Carolina, 29902, United States

  • Clinica Oftalmologica del Caribe (COFCA)

    RECRUITING

    Barranquilla, 080001 - Atlantico, Colombia

  • Clinica de Oftalmologia Sandiego

    RECRUITING

    Medellín, 050021 - Antioquia, Colombia

  • Clínica Imbanaco S.A.S

    RECRUITING

    Cali, 760042, Colombia

  • Connecticut Eye Consultants, P.C.

    RECRUITING

    Danbury, Connecticut, 06810, United States

  • Envision Ocular, LLC

    RECRUITING

    Bloomfield, New Jersey, 07003, United States

  • Erie Retina Research

    RECRUITING

    Erie, Pennsylvania, 16505, United States

  • Espaço Médico de Coimbra

    RECRUITING

    Coimbra, 3030-163, Portugal

  • Fakultni nemocnice Kralovske

    RECRUITING

    Prague, PSČ 100 34, Czechia

  • Florida Retina Institute

    RECRUITING

    Orlando, Florida, 32806, United States

  • Fundacion Oftalmologica Nacional

    RECRUITING

    Bogotá, 110231 - D.C., Colombia

  • Graystone Eye

    RECRUITING

    Hickory, North Carolina, 28602, United States

  • Hopital Intercommunal De Creteil

    RECRUITING

    Créteil, 94010, France

  • Hospital General de Catalunya

    RECRUITING

    Barcelona, 8195, Spain

  • IPEPO - Instituto Paulista de Estudos e Pesquisas em Oftalmologia (Site 332)

    RECRUITING

    São Paulo, 04038-032, Brazil

  • Illinois Retina Associates

    RECRUITING

    Joliet, Illinois, 60435, United States

  • Klaudians Hospital - Ophthalmology department

    RECRUITING

    Mladá Boleslav, 293 01, Czechia

  • Long Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY

    RECRUITING

    Great Neck, New York, 11021, United States

  • Maine Eye Center (Site 097)

    RECRUITING

    Portland, Maine, 04101, United States

  • Mid Atlantic Retina Specialists

    RECRUITING

    Hagerstown, Maryland, 21740, United States

  • NC Retina

    RECRUITING

    Cary, North Carolina, 27511, United States

  • NC Retina Associates

    RECRUITING

    Wake Forest, North Carolina, 27587, United States

  • Northeast Wisconsin Retina Associates

    RECRUITING

    Appleton, Wisconsin, 54914, United States

  • Northern California Retina Vitreous Associates Medical Group, Inc.

    RECRUITING

    Mountain View, California, 94040, United States

  • Oftalvist

    RECRUITING

    Burjassot -(Valencia), 46100, Spain

  • Orange County Retina Medical Group

    RECRUITING

    Santa Ana, California, 92705, United States

  • Pacific Northwest Retina

    RECRUITING

    Bellevue, Washington, 98004, United States

  • Palmetto Retina Center

    RECRUITING

    Florence, South Carolina, 29501, United States

  • Palmetto Retina Center

    RECRUITING

    West Columbia, South Carolina, 29169, United States

  • Presidio Ospedaliero Universitario "Santa Maria della Misericordia" Clinica Oculistica - Padiglione 7 - Piano 3

    RECRUITING

    Udine, 33100, Italy

  • RSC Research LLC

    RECRUITING

    Denver, Colorado, 80222, United States

  • Retina Associates of Western NY, PC (Site 051)

    RECRUITING

    Rochester, New York, 14620, United States

  • Retina Associates, LLC

    RECRUITING

    Lenexa, Kansas, 66215, United States

  • Retina Consultants of Minnesota

    RECRUITING

    Edina, Minnesota, 55435, United States

  • Retina Consultants of Southern Colorado

    RECRUITING

    Colorado Springs, Colorado, 80909, United States

  • Retina Consultants of Southern Colorado

    RECRUITING

    Pueblo, Colorado, 81008, United States

  • Retina Consultants of Texas

    RECRUITING

    Bellaire, Texas, 77401, United States

  • Retina Consultants of Texas

    RECRUITING

    Katy, Texas, 77494, United States

  • Retina Consultants of Texas

    RECRUITING

    San Antonio, Texas, 78240, United States

  • Retina Consultants of Texas

    RECRUITING

    Schertz, Texas, 78154, United States

  • Retina Consultants, LLC

    RECRUITING

    Salem, Oregon, 97302, United States

  • Retina Consultants, P.C.

    RECRUITING

    Manchester, Connecticut, 06042, United States

  • Retina Group of Florida

    RECRUITING

    Fort Myers, Florida, 33912, United States

  • Retina Group of Florida (Site 065)

    RECRUITING

    Sarasota, Florida, 34232, United States

  • Retina Group of New England

    RECRUITING

    Waterford, Connecticut, 06385, United States

  • Retina Research Institute at New England Retina Consultants, PC

    RECRUITING

    Springfield, Massachusetts, 01107, United States

  • Salt Lake Retina

    RECRUITING

    West Jordan, Utah, 84088, United States

  • Southeastern Retina Associates

    RECRUITING

    Hixson, Tennessee, 37343, United States

  • Southeastern Retina Associates (Site 095)

    RECRUITING

    Johnson City, Tennessee, 37604, United States

  • Southeastern Retina Associates, P.C.

    RECRUITING

    Knoxville, Tennessee, 37922, United States

  • Tennessee Retina

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • Texas Retina Associates

    RECRUITING

    Fort Worth, Texas, 76104, United States

  • The Retina Partners

    RECRUITING

    Encino, California, 91436, United States

  • University Retina & Macula Associates, P.C.

    RECRUITING

    Lemont, Illinois, 60439, United States

  • VISUS spol. s r.o.

    RECRUITING

    Náchod, 54701, Czechia

  • Vistar Eye Center (Site 129)

    RECRUITING

    Roanoke, Virginia, 24019, United States

  • Wolfe Eye Clinic

    RECRUITING

    West Des Moines, Iowa, 50266, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.