New eye injection could change treatment for wet AMD

NCT ID NCT07496567

Recruiting now Disease control Sponsor: EyeBiotech Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 07, 2026 · Updated 7 times

Summary

This study tests a new drug called tiespectus (MK-8748) against the current standard treatment, aflibercept, for people with wet age-related macular degeneration (AMD). About 960 participants will receive injections into the eye and be followed for a year to see if tiespectus can improve vision as well as or better than aflibercept. The goal is to find a new option for those who don't respond well to existing treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tiespectus (also called MK-8748 or EYE201)
What this could lead to: If it works, this could offer a new treatment option for wet age-related macular degeneration, potentially helping people maintain or improve their vision.
What could go wrong: This is an early-to-mid stage trial, so the drug may not work better than the current standard treatment. There are also risks from the eye injection itself, such as infection or inflammation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

AIBILI Azinhaga de Santa Comba
RECRUITING

Coimbra, 3000-548, Portugal
Asheville Eye Associates, Retina Division (Site 077)
RECRUITING

Asheville, North Carolina, 28803, United States
Associated Retina Consultants - Gilbert
RECRUITING

Gilbert, Arizona, 85259, United States
Astra Clinic.s.r.o.
RECRUITING

Prague, 184 00, Czechia
Austin Retina Associates
RECRUITING

Round Rock, Texas, 78681, United States
Austin Retina Associates
RECRUITING

San Marcos, Texas, 78666, United States
Axon Clinical, s.r.o. (Site 400)
RECRUITING

Prague, 150 00, Czechia
Budapest Retina Associates
RECRUITING

Budapest, 1133, Hungary
Butchertown Clinical Trials
RECRUITING

Louisville, Kentucky, 40206, United States
Cascade Medical Research Institute, LLC
RECRUITING

Springfield, Oregon, 97477, United States
Center for Retina and Macular Disease (Site 062)
RECRUITING

Winter Haven, Florida, 33880, United States
Centre Ophtalmologique Saint Exupéry
RECRUITING

Saint-Cyr-sur-Loire, 37540, France
Centre d'Ophtalmologie Paradis-Monticelli
RECRUITING

Marseille, 13008, France
Charleston Neuroscience Institute
RECRUITING

Ladson, South Carolina, 29456, United States
Charleston Neuroscience Institute (Site 034)
RECRUITING

Beaufort, South Carolina, 29902, United States
Clinica Oftalmologica del Caribe (COFCA)
RECRUITING

Barranquilla, 080001 - Atlantico, Colombia
Clinica de Oftalmologia Sandiego
RECRUITING

Medellín, 050021 - Antioquia, Colombia
Clínica Imbanaco S.A.S
RECRUITING

Cali, 760042, Colombia
Connecticut Eye Consultants, P.C.
RECRUITING

Danbury, Connecticut, 06810, United States
Envision Ocular, LLC
RECRUITING

Bloomfield, New Jersey, 07003, United States
Erie Retina Research
RECRUITING

Erie, Pennsylvania, 16505, United States
Espaço Médico de Coimbra
RECRUITING

Coimbra, 3030-163, Portugal
Fakultni nemocnice Kralovske
RECRUITING

Prague, PSČ 100 34, Czechia
Florida Retina Institute
RECRUITING

Orlando, Florida, 32806, United States
Fundacion Oftalmologica Nacional
RECRUITING

Bogotá, 110231 - D.C., Colombia
Graystone Eye
RECRUITING

Hickory, North Carolina, 28602, United States
Hopital Intercommunal De Creteil
RECRUITING

Créteil, 94010, France
Hospital General de Catalunya
RECRUITING

Barcelona, 8195, Spain
IPEPO - Instituto Paulista de Estudos e Pesquisas em Oftalmologia (Site 332)
RECRUITING

São Paulo, 04038-032, Brazil
Illinois Retina Associates
RECRUITING

Joliet, Illinois, 60435, United States
Klaudians Hospital - Ophthalmology department
RECRUITING

Mladá Boleslav, 293 01, Czechia
Long Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY
RECRUITING

Great Neck, New York, 11021, United States
Maine Eye Center (Site 097)
RECRUITING

Portland, Maine, 04101, United States
Mid Atlantic Retina Specialists
RECRUITING

Hagerstown, Maryland, 21740, United States
NC Retina
RECRUITING

Cary, North Carolina, 27511, United States
NC Retina Associates
RECRUITING

Wake Forest, North Carolina, 27587, United States
Northeast Wisconsin Retina Associates
RECRUITING

Appleton, Wisconsin, 54914, United States
Northern California Retina Vitreous Associates Medical Group, Inc.
RECRUITING

Mountain View, California, 94040, United States
Oftalvist
RECRUITING

Burjassot -(Valencia), 46100, Spain
Orange County Retina Medical Group
RECRUITING

Santa Ana, California, 92705, United States
Pacific Northwest Retina
RECRUITING

Bellevue, Washington, 98004, United States
Palmetto Retina Center
RECRUITING

Florence, South Carolina, 29501, United States
Palmetto Retina Center
RECRUITING

West Columbia, South Carolina, 29169, United States
Presidio Ospedaliero Universitario "Santa Maria della Misericordia" Clinica Oculistica - Padiglione 7 - Piano 3
RECRUITING

Udine, 33100, Italy
RSC Research LLC
RECRUITING

Denver, Colorado, 80222, United States
Retina Associates of Western NY, PC (Site 051)
RECRUITING

Rochester, New York, 14620, United States
Retina Associates, LLC
RECRUITING

Lenexa, Kansas, 66215, United States
Retina Consultants of Minnesota
RECRUITING

Edina, Minnesota, 55435, United States
Retina Consultants of Southern Colorado
RECRUITING

Colorado Springs, Colorado, 80909, United States
Retina Consultants of Southern Colorado
RECRUITING

Pueblo, Colorado, 81008, United States
Retina Consultants of Texas
RECRUITING

Bellaire, Texas, 77401, United States
Retina Consultants of Texas
RECRUITING

Katy, Texas, 77494, United States
Retina Consultants of Texas
RECRUITING

San Antonio, Texas, 78240, United States
Retina Consultants of Texas
RECRUITING

Schertz, Texas, 78154, United States
Retina Consultants, LLC
RECRUITING

Salem, Oregon, 97302, United States
Retina Consultants, P.C.
RECRUITING

Manchester, Connecticut, 06042, United States
Retina Group of Florida
RECRUITING

Fort Myers, Florida, 33912, United States
Retina Group of Florida (Site 065)
RECRUITING

Sarasota, Florida, 34232, United States
Retina Group of New England
RECRUITING

Waterford, Connecticut, 06385, United States
Retina Research Institute at New England Retina Consultants, PC
RECRUITING

Springfield, Massachusetts, 01107, United States
Salt Lake Retina
RECRUITING

West Jordan, Utah, 84088, United States
Southeastern Retina Associates
RECRUITING

Hixson, Tennessee, 37343, United States
Southeastern Retina Associates (Site 095)
RECRUITING

Johnson City, Tennessee, 37604, United States
Southeastern Retina Associates, P.C.
RECRUITING

Knoxville, Tennessee, 37922, United States
Tennessee Retina
RECRUITING

Nashville, Tennessee, 37203, United States
Texas Retina Associates
RECRUITING

Fort Worth, Texas, 76104, United States
The Retina Partners
RECRUITING

Encino, California, 91436, United States
University Retina & Macula Associates, P.C.
RECRUITING

Lemont, Illinois, 60439, United States
VISUS spol. s r.o.
RECRUITING

Náchod, 54701, Czechia
Vistar Eye Center (Site 129)
RECRUITING

Roanoke, Virginia, 24019, United States
Wolfe Eye Clinic
RECRUITING

West Des Moines, Iowa, 50266, United States

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