Vascular disorder

Researchers are testing whether an educational and implementation tool helps hospitals follow best-practice guidelines for preventing second strokes caused by heart conditions. The trial enrolls about 2,400 patients who have had an ischemic stroke or a transient ischemic attack. …

Researchers are testing whether seltoplasmid, a gene therapy injected into the calf muscle, can improve outcomes for people with type 2 diabetes who have poor blood flow to the foot and a non-healing ulcer. All participants first undergo a standard procedure to restore blood flow…

This Phase 3 trial will test whether a combination of three cholesterol-lowering drugs—bempedoic acid, ezetimibe, and a high-intensity statin—can reduce and stabilize plaque buildup in the coronary arteries. The study enrolls 103 adults with coronary atherosclerosis who have neve…

This phase 2 trial is testing whether the drug ivonescimab can help control advanced or metastatic adrenal cancers, specifically adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL), that have not responded to prior treatment. About 20 adults with these rare c…

This trial tests whether treating high blood pressure in pregnancy to a stricter target (below 140/90) is better than the usual approach (below 160/110) for women with gestational hypertension or preeclampsia without severe features. About 4,120 pregnant women will be randomly as…

This trial tests whether a drug called carfilzomib, given directly to the liver through an implanted pump, is safe for people whose colon, adrenal, or bile duct cancer has spread to the liver and persists after prior pump therapy. Participants receive weekly infusions of the drug…

This study tests whether the drug telaglenastat, taken twice daily for 12 weeks, can safely lower blood pressure in the lungs and improve heart and lung function in adults with pulmonary hypertension. About 28 participants will receive the drug on top of their usual care. The mai…

This study tests a program for new mothers who had high blood pressure during pregnancy. Participants wear a FitBit and receive weekly messages with personalized activity goals. The goal is to see if this approach increases daily steps and improves blood pressure, and whether mom…

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

Researchers are testing whether a lower dose of the clot-dissolving drug alteplase can treat life-threatening pulmonary embolism as effectively as the standard full dose while causing less severe bleeding. The trial enrolls adults with acute high-risk pulmonary embolism, a condit…

Researchers are testing whether a standardized automated blood pressure measurement protocol in Australian general practice clinics improves hypertension control among adults. The protocol uses a validated device that takes several readings automatically after a five-minute rest,…

This pilot study tests a procedure called left atrial appendage occlusion (LAAO) using the Watchman Flx PRO device in 40 dialysis patients with atrial fibrillation. The goal is to see if it safely reduces stroke and major bleeding compared to standard care. Participants will be f…

This study compares two treatments for when a leg artery stent narrows again (in-stent restenosis). About 578 patients will receive either a drug-coated balloon or a drug-eluting stent, both of which release medication to keep the artery open. The goal is to see which approach re…

This study tests whether using a 21-question tool to understand a person's daily habits, then giving tailored advice, can lower blood pressure more than routine counseling. Researchers will compare two groups of adults with hypertension over three months. The goal is to see if pe…

This observational study is looking at whether Ferretab comp., an oral iron and folic acid supplement, can improve anemia and heart-related symptoms in adults who also have coronary artery disease or heart failure. Participants take the supplement for 12 weeks as part of their us…

Researchers are studying how heart arteries change after a blocked vessel is opened with a paclitaxel drug-coated balloon instead of a metal stent. The balloon delivers a drug to the artery wall and then is removed, leaving no permanent implant. About 150 adults who had this proc…

Researchers are testing whether adding a PCSK9 inhibitor to standard statin therapy can stabilize vulnerable plaques in the carotid artery, the main blood vessel to the brain. The trial enrolls 120 adults with carotid narrowing and high-risk plaque features. Participants receive …

This study explores whether measuring a hormone called renin can help doctors choose the best first medication for people with early-stage high blood pressure. Adults with low renin levels are randomly assigned to receive either spironolactone or a standard blood pressure drug fo…

This study tests whether a tablet-based brain training program and/or a powerful cholesterol-lowering drug (PCSK9 inhibitor) can improve thinking and memory in 420 adults aged 55-80 with narrowed brain arteries. Participants will be split into four groups, combining or not combin…

Researchers compare two approaches for adults with small unruptured brain aneurysms found by chance: regular imaging surveillance without initial treatment, or immediate endovascular or surgical repair. The trial enrolls 600 adults aged 35 to 75 with aneurysms measuring 2 to 7.9 …

This study tests a new drug called EPN-701 for calciphylaxis, a rare condition causing painful skin sores with no approved treatment. About 60 adults with moderate to severe pain and at least one open sore will receive the drug. The main goals are to see if EPN-701 safely reduces…

Researchers are testing an experimental eye injection called GenSci148 in people with neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO). GenSci148 is a fusion protein designed to block four proteins involved in blo…

Researchers are testing whether adding tirofiban to standard antiplatelet therapy improves recovery for people whose ruptured brain aneurysm is repaired with a stent. The trial enrolls adults with acute subarachnoid hemorrhage who receive stent-assisted coiling within 72 hours of…

This pilot study tests whether giving semaglutide (Ozempic) to 100 stroke patients who had a clot-removal procedure can improve recovery. Patients are randomly assigned to receive weekly injections for 12 weeks or no drug. The main goal is to see if a larger, definitive trial is …

Researchers are testing whether trametinib, an FDA-approved cancer drug, can help infants with RASopathies who have a severe, life-threatening heart condition called hypertrophic cardiomyopathy. The trial enrolls about 25 babies with a confirmed genetic diagnosis. Participants re…

This study tests whether combining a gentle nerve stimulation device worn on the ear (taVNS) with intensive arm therapy (CIMT) can help infants and toddlers (8–24 months) with perinatal brain injury improve movement in their weaker arm and hand. The therapy involves placing a mit…

Researchers are testing whether a drug-coated balloon alone can keep heart arteries open after clearing a chronic total blockage, without leaving a permanent metal stent. The study plans to enroll 38 adults with a long-standing coronary occlusion and angina or documented ischemia…

Researchers are testing an experimental oral drug called MN-08 in healthy adults to see how safe and tolerable it is. The trial gives participants either MN-08 or a placebo for about a week and measures side effects, vital signs, heart rhythm, and blood test changes. It also trac…

This study looks at people with a rare lung condition called CTEPH who have done well after a procedure (balloon angioplasty) and are taking a drug called riociguat. The goal is to see if stopping the drug is as safe as continuing it. About 150 participants will be randomly assig…

Researchers are testing an experimental antibody called SZN-8141 in people with diabetic macular edema, a swelling of the retina that can blur vision. About nine participants will each receive a single injection of SZN-8141 into the eye, with small groups getting increasing doses…

This registry will follow 2000 people with complex coronary artery disease who receive the Inspiron EVO drug-eluting stent. The stent is designed to be easier to deliver and stronger than standard stents. Researchers will track how well the stent works and whether it reduces hear…

This trial tests whether adding nicorandil, a drug that widens blood vessels, to standard rheumatoid arthritis (RA) treatment can reduce the buildup of plaque in arteries. People with RA have a higher risk of atherosclerosis, which can lead to heart attacks and strokes. Researche…

This early-phase trial is testing a new cell therapy called GT719 for several immune-mediated kidney diseases, including IgA nephropathy and membranous nephropathy. The therapy uses specially engineered immune cells to target and potentially control the disease. The study will en…

This study tests whether two heart failure medications, dapagliflozin and spironolactone, can help the heart recover better after aortic valve replacement. About 445 adults with severe aortic stenosis will take one or both drugs daily for 12 months. The goal is to see if these me…

This trial tests whether a sirolimus-coated balloon, guided by intravascular ultrasound, works as well as a standard drug-eluting stent for people with acute coronary syndrome and large-vessel heart blockages. Participants are randomly assigned to receive either the balloon witho…

Researchers test whether a digital care pathway app plus non-real-time messaging with a nurse helps adults in primary care lower their systolic blood pressure. About 600 patients with uncontrolled hypertension receive usual care, usual care plus the app, or usual care plus the ap…

This trial tests whether adding laser therapy to standard gum surgery improves treatment of advanced periodontitis. Adults with stage I to III periodontitis who still have deep pockets after initial non-surgical care will receive open flap debridement, a procedure that lifts the …

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

Researchers are testing an experimental treatment called AB126, made from neural exosomes, in adults who have had a moderate to severe acute ischemic stroke and who showed limited improvement after a procedure to clear the blocked blood vessel. The trial aims to find out whether …

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This trial tests a medical device that has not been approved or cleared by the U.S. FDA. Researchers want to learn whether the device is safe and whether it can help people with a specific condition. Participants receive the device as part of the study, and the team monitors thei…

This trial tests whether the anesthetic remimazolam keeps blood pressure more stable than the standard drug propofol in adults undergoing surgery to repair an aortic aneurysm. Maintaining steady blood pressure during these procedures helps protect vital organs. Researchers will m…

This early-stage study tests whether it is safe to take nitroglycerin spray (used for chest pain) together with an experimental drug called nurandociguat (designed to help kidneys) in 36 adults with stable coronary artery disease. Both drugs widen blood vessels, so the main conce…

Some newborns with HIE, a brain injury from lack of oxygen at birth, also develop heart problems. This pilot trial tests whether starting a heart medication called dobutamine early, before heart failure signs appear, is feasible and safe. Forty babies receiving cooling therapy wi…

The RELEASE trial tests whether adults aged 65 and older with stable ischemic heart disease can safely stop their daily low-dose aspirin. Researchers will compare stopping aspirin against continuing it in 7,000 participants who have been free of heart events for at least two year…

This trial tests whether adding Yiqi Fumai lyophilized injection to standard heart failure treatment improves symptoms and reduces heart strain in adults with chronic heart failure caused by coronary heart disease. About 100 participants at four hospitals in China will receive th…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This 52-week trial tests whether combining a structured lifestyle program with a mushroom-based supplement and the drug bupropion helps overweight adults lose weight and lower cardiometabolic risk. About 250 adults aged 18 to 55 with a BMI between 25 and 35 will be randomly assig…

This pilot study tests whether giving new mothers with preeclampsia or gestational hypertension a blood pressure cuff, extra education, and a reminder bracelet helps them manage their blood pressure at home. About 40 participants will receive these tools before leaving the hospit…

This study tests whether using a patient's genetic information to choose anti-platelet drugs can lower bleeding risks compared to standard care. About 1,760 high-risk patients receiving a heart stent will be assigned to either a personalized drug plan or usual therapy. The goal i…

This trial tests a new heart valve called the INOVARE SAFESYNC, which doctors implant through a tube in the leg, avoiding open-heart surgery. The study enrolls 40 people with severe aortic stenosis, a narrowing of the heart's main valve, who are at intermediate or higher risk for…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This study tests whether a nurse-led, community-based program can help lower blood pressure in adults aged 25 and older with uncontrolled hypertension in Monrovia, Liberia. Trained community health nurses provide medication and lifestyle counseling at mobile clinics in high-traff…

This study tests whether combining non-invasive light therapy on the head, electrical stimulation cycling for the arms, and cognitive tasks can improve thinking and arm movement in adults who have had a stroke. Participants attend 10 sessions over 2 weeks, and researchers measure…

Peripheral artery disease can completely block the superficial femoral artery in the thigh, cutting off blood flow to the leg. This trial tests a minimally invasive procedure that uses a rotating device to shave away the blockage, followed by a drug-coated balloon to widen the ar…

This trial tests a 'Hospital-to-Home' support program for people recovering from acute coronary syndrome, a group of heart emergencies like heart attacks. Participants are randomly assigned to either the structured program or standard education. The program uses behavior change m…

This trial studies people with pulmonary arterial hypertension (PAH) who live permanently above 2600 meters. Researchers want to see if spending one week at sea level and then returning to high altitude changes pressure in the lung's blood vessels. They will measure heart and lun…

This trial tests whether giving adolescent girls a daily multiple micronutrient supplement (with or without extra nutrients) improves their growth, brain function, bone health, and overall well-being compared to the standard weekly iron-folic acid pill. About 3,000 girls aged 10–…

This trial investigates whether adding early lumbar drainage to standard care (a drain in the head plus clot-dissolving medication) improves long-term outcomes for people with bleeding into the brain's fluid-filled spaces. The study includes adults aged 18 to 85 who have had a fi…

This study tests whether medically tailored meals, prepared to support kidney and heart health, can improve blood pressure and kidney function in Veterans with chronic kidney disease. About 100 participants will be randomly assigned to receive these meals or usual care for three …

This trial tests whether a procedure to reopen a blocked carotid artery in the neck can improve cognitive function in people who have had a stroke or mini-stroke and now have thinking or memory problems. Participants are randomly assigned to receive standard medical care alone, o…

This trial tests whether a granule form of the Chinese herbal formula Huayu Jiedu (FTFY-919) works as well as the traditional decoction for people with acute hypertensive intracerebral hemorrhage, a type of stroke caused by bleeding in the brain. About 300 adults who have had a b…

This trial tests whether treadmill training with a robotic cable that gently pulls walkers side-to-side can improve balance and daily walking in adults who had a stroke. Participants complete 20 high-intensity treadmill sessions, either with the robotic pulling forces or without …

This study tests whether adding stem cells to standard cooling therapy helps newborns with brain injury from lack of oxygen at birth. Forty infants will receive either stem cells from donated placentas or a placebo. Researchers will track death and developmental delays for up to …

This trial tests whether an 8-week home-based telerehabilitation program, delivered through a mobile app, can safely improve exercise capacity in adults with pulmonary arterial hypertension (PAH). PAH causes severe shortness of breath and fatigue, and many patients cannot easily …

This pilot study tests whether stroke survivors can follow a self-managed exercise program at home to maintain their health. Participants first complete an 18-session guided program with respiratory, strengthening, and cardiovascular exercises, plus weekly virtual coaching sessio…

This study tests a new, simple procedure done right after doctors remove a blood clot from the brain in severe stroke patients. The procedure involves briefly inflating and deflating a tiny balloon to gently restore blood flow, which may prevent extra brain damage. About 288 to 4…

This trial tests whether a newer ventilation method, called flow-controlled ventilation, keeps the lungs and diaphragm in better shape than the standard pressure-controlled method during elective heart bypass surgery. About 154 adults scheduled for on-pump coronary artery bypass …

This study compares two methods to remove large blood clots from the brain during a stroke: using a super large suction catheter versus a stent retriever. About 708 adults with acute ischemic stroke will be randomly assigned to one of the two techniques. The goal is to see which …

This trial tests whether starting a powerful cholesterol-lowering combination right after a heart attack can make the fatty plaques in coronary arteries more stable. Researchers will compare an early intensive strategy using a high-intensity statin, ezetimibe, and inclisiran agai…

This trial tests whether empagliflozin, a drug used for diabetes, improves blood vessel and nerve function in adults aged 45 to 75 with prehypertension. Participants take the drug or a placebo for two weeks, then switch, while a control group with normal blood pressure is observe…

This study tests a stent (Carotid WALLSTENT) used with a special brain protection system (ENROUTE NPS) in 60 Chinese patients with narrowed carotid arteries. The goal is to see if the combination can be safely delivered to prevent strokes. Patients must have significant artery na…

This trial tests whether mazdutide, a weekly injection that targets GLP-1 and glucagon receptors, can safely reduce portal pressure in overweight adults with compensated cirrhosis and clinically significant portal hypertension. Participants receive 16 weeks of mazdutide, with the…

This study tests whether a low-dose anti-inflammatory drug called colchicine can help people who have had a brain hemorrhage (a type of stroke) recover better and avoid future heart attacks or strokes. About 1,125 adults with signs of artery disease will take either colchicine or…

This trial studies people with pulmonary arterial hypertension, a condition where high blood pressure strains the lungs, who live permanently above 2600 meters. Researchers test whether spending one week at sea level and then returning to altitude changes how far participants can…

This study will look at how well a drug called ARNi (sacubitril/valsartan) lowers blood pressure in 500 adults with hypertension in the United Arab Emirates. Researchers will compare it to standard treatments like ACE inhibitors and calcium channel blockers. The goal is to see if…

This study tests an experimental drug called HRS-1780 in people with uncontrolled or resistant hypertension—high blood pressure that stays high despite treatment. The trial compares three different doses of HRS-1780 against a placebo to see if it safely lowers blood pressure. Par…

This study tests a medicine called tenecteplase for people who have a stroke but don't know exactly when it started, like waking up with symptoms. About 352 adults will get either tenecteplase or standard care after a simple CT scan. The goal is to see if the drug helps them reco…

This study compares two blood thinners—apixaban (Eliquis) and warfarin (Coumadin)—in 460 people with advanced heart failure who have a HeartMate 3 heart pump. The goal is to see which drug better prevents strokes, pump clots, and serious bleeding. Participants must have had their…

This trial tests a small device called the C-MIC System, which is implanted under the skin and delivers a constant low-level electrical current to the heart. The goal is to see if this microcurrent can improve heart pumping ability, exercise capacity, and quality of life in peopl…

This pilot study is testing whether a Bifidobacterium probiotic supplement can help lower blood pressure in 30 middle-aged Chinese adults with untreated hypertension. Participants will take the probiotic for 12 weeks, and researchers will monitor their blood pressure and other he…

This trial compares two types of replacement heart valves used in a procedure called TAVI for people with severe aortic valve stenosis and a small aortic annulus. The two valves are the Meril Octapro+ and the Abbott Navitor. Researchers want to see which design provides better sa…

This study tests a brain-computer interface called BrainGate2 in people with expressive aphasia, a condition where stroke damage makes it hard to speak. Researchers place small sensors in the brain areas that control speech, then record brain activity while participants try to sp…

This trial tests a support program for adults with glaucoma who struggle to take their eye drops regularly or attend clinic visits. Participants identify their main barrier, such as forgetfulness or difficulty using drops, and receive matching help like education, reminders, or t…

This study tests a new non-invasive brain stimulation method that targets deep brain structures through the scalp, without surgery, to improve arm and hand function in people who had a stroke at least 12 weeks ago. Participants receive either active stimulation or a sham version,…

This trial tests whether a procedure to remove blood clots from the brain, called endovascular treatment, can improve recovery in people who have had a severe stroke with a very large area of brain damage. Participants receive either the clot-removal procedure plus standard medic…

This trial tests whether a rapid combination of minimally invasive surgery, intensive blood pressure lowering, and a clot-stabilizing drug can improve recovery after a bleeding stroke. Adults with a moderate to large bleed in the brain are randomly assigned to receive this early …

This trial tests whether a home-based electrical stimulation device can help people recovering from stroke improve their walking. Participants will use the device on leg muscles for 30 minutes, five times a week, for 12 weeks, with remote support via a smartphone app. The study c…

This trial tests whether using ultrasound to mark the correct spot on the back before spinal anesthesia improves success compared with the traditional method of feeling the bones. Sixty women having planned cesarean sections will be randomly assigned to either ultrasound marking …

This study looks at whether a clot-busting drug called prourokinase can improve recovery in people who have an acute ischemic stroke, when given within 4.5 hours of symptoms starting. About 3,000 adults will receive the drug intravenously and be followed for 90 days to see how we…

This phase 3 trial is testing whether Angong Niuhuang, a traditional Chinese medicine, can improve recovery in people who have had a bleeding stroke (intracerebral hemorrhage). About 1,100 adults who are eligible for non-surgical management will receive either the herbal pill or …

This trial compares two common treatments—hypertonic saline and mannitol—to see which is better at reducing dangerously high pressure inside the skull after a severe traumatic brain injury. The study includes 100 adults with severe head injuries and uses a simple ultrasound measu…

This trial tests whether clazakizumab, an experimental anti-inflammatory drug, can lower a blood marker of inflammation called hsCRP in adults who have elevated levels and are at increased risk for heart problems. Participants must have conditions like established heart disease, …

This trial tests whether genistein, a natural compound found in soy, can reduce inflammation and improve blood vessel health in people living with HIV. Even with effective HIV treatment, the body stays inflamed, raising the risk of heart disease and other problems. The study give…

This trial tests whether a traditional Chinese herbal formula, Fuzheng Yangxin, can help people recover better after coronary artery bypass grafting (CABG), a common heart surgery. The study includes 230 patients who have the surgery and show signs of a specific imbalance (qi-yin…

This trial tests whether nicotinamide riboside, a form of vitamin B3, can improve walking ability in people aged 50 and older with peripheral artery disease (PAD). Participants will take either the supplement or a placebo for six months. The main goal is to see if the supplement …

This trial tests a 12-week community program for older stroke survivors who also have high blood pressure or type 2 diabetes. Participants take part in physical activities like exercise and nutrition education, plus cognitive games on an AI-enabled large screen. The goal is to se…

This trial tests whether a team-based care program, initiated in the emergency department, can help adults with severely elevated blood pressure achieve better control. Participants are randomly assigned to either the team-based program or usual care. The team-based program inclu…

This clinical trial is evaluating an investigational medical device that has not been approved or cleared by the U.S. FDA. The study aims to assess the device's safety and how well it works in participants with a specific medical condition. By gathering data on the device's perfo…

This trial tests whether a drug called recombinant human prourokinase (rhPro-UK) can improve recovery in people who have had a stroke caused by a blocked medium-sized blood vessel in the brain, when given 4.5 to 24 hours after symptoms begin. Participants are selected using brain…

This trial compares two ways of managing high blood pressure: using a cuffless wearable device that tracks blood pressure continuously for 24 hours versus traditional office measurements. About 3,000 adults with high blood pressure will be randomly assigned to one of the two stra…

This Phase 3 trial is testing whether a microneedle pad delivering botulinum toxin A can improve symptoms of Raynaud's phenomenon and digital ulcers in people with systemic sclerosis. The study compares the microneedle treatment to a placebo, measuring changes in finger temperatu…

This trial tests whether a non-invasive brain stimulation technique, called transcranial temporal interference stimulation, can improve swallowing in adults who have difficulty swallowing after an ischemic stroke. Participants will receive either active or sham stimulation combin…

This trial tests whether epidural spinal cord stimulation can help people with severe brain injury breathe without a ventilator. Ten patients with stroke or traumatic brain injury who need mechanical ventilation will receive a surgically implanted electrode that delivers electric…

This trial is testing whether preparing a blocked leg artery with a special 'scoring' balloon before using a drug-coated balloon improves outcomes compared to using a standard balloon. The study involves people with severe leg artery disease (critical limb-threatening ischemia) w…

This trial investigates whether combining two behavioral therapies can help people with non-fluent aphasia—a condition where stroke damages the brain's language centers, making speech difficult. The approach uses Melodic Intonation Therapy (MIT), which uses singing-like intonatio…

This trial tests whether icosapent ethyl, a purified form of fish oil, can stabilize high-risk coronary plaques in people with heart disease. Participants have plaques that narrow a major heart artery by 30–70% and show at least one high-risk feature on a CT scan. Half will take …

This trial tests whether aspirin and a non-invasive physical therapy called ischemic conditioning can slow the progression of moyamoya disease, a rare brain vessel disorder that can cause strokes and cognitive decline. The study enrolls adults with moyamoya disease or syndrome wh…

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This study looks at whether switching to a higher-dose eye injection called aflibercept 8 mg can allow people with neovascular age-related macular degeneration (nAMD) or diabetic macular oedema (DME) to go longer between treatments. It follows adults in Portugal who have already …

This trial tests whether a simple, non-invasive technique called remote ischemic preconditioning (RIPC) can reduce brain damage after an aneurysmal subarachnoid hemorrhage, a severe type of stroke. The procedure involves briefly inflating a blood pressure cuff on the leg to restr…

This trial is testing a new medical device called FRED X, designed to treat brain aneurysms—weak spots in blood vessels that can bulge and potentially rupture. The study will enroll about 15 people with a single untreated aneurysm to see if the device, used with blood-thinning me…

This study tracks the safety and effectiveness of J&J MedTech devices used to remove blood clots in people with acute ischemic stroke. It will follow about 5,000 adults who receive these devices as part of their routine care, measuring how well blood flow is restored and how pati…

This trial tests whether an experimental drug called CS1, taken as a daily pill, can improve blood vessel function in people with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs makes the heart work harder. Participants will receive CS1 o…

This trial tests whether giving praziquantel three times a year, instead of the standard once a year, can improve liver fibrosis (scarring) caused by schistosomiasis in people aged 15-40 in Uganda. Participants with liver fibrosis will be randomly assigned to one of two treatment…

This trial tests whether Cerebrolysin, given after a procedure to remove a blood clot from the brain, can reduce tissue damage and improve recovery in people with acute ischemic stroke. The study involves 100 adults aged 18 to 80 who undergo successful clot removal within 6 to 24…

This study tests whether giving creatine monohydrate, a popular sports supplement, twice a day for 12 weeks is safe and practical for children and teenagers recovering from a moderate-to-severe brain injury, including traumatic brain injury or stroke. The trial will enroll 46 par…

This trial is testing whether a new heart valve device, called Myval, can safely and effectively treat people with severe aortic regurgitation—a condition where the heart's aortic valve doesn't close properly, causing blood to leak backward. The study involves about 164 adults wh…

This study tests a new laser system designed to vaporize plaque in blocked coronary arteries before doctors place a stent. The trial compares the new laser device to an existing one in about 218 people with severe heart artery narrowing. The main goal is to see if the new system …

This trial tests whether faricimab, an eye injection, can improve vision and reduce swelling in South Asian patients with diabetic macular edema (DMO), a complication of diabetes that can lead to blindness. Previous studies mostly included Caucasian or East Asian participants, le…

This trial tests whether rimegepant, a newer migraine medication, works as well as flunarizine, an older preventive, for reducing days with moderate-to-severe dizziness in people with vestibular migraine. About 400 adults aged 18 to 75 will take one of the two drugs daily for 12 …

This trial tests whether giving empagliflozin before or after a procedure to open a blocked heart artery (primary PCI) reduces heart muscle injury during a heart attack. Adults aged 18-75 of South Asian origin having their first heart attack will be randomly assigned to receive e…

This phase 3 trial is testing whether giving a clot-busting drug before mechanical thrombectomy (a procedure to physically remove a blood clot) improves outcomes for people with severe strokes caused by large vessel occlusion. Participants are randomly assigned to receive tenecte…

This trial tests whether a minimally invasive heart bypass surgery, done through a small incision on the left side of the chest, helps frail adults aged 60 and older recover better than the traditional approach of opening the breastbone. Participants are randomly assigned to one …

This trial tests a new device called the Angimis Atherectomy System, which uses laser energy to break up plaque in coronary arteries that are too narrow or hardened for standard balloon or stent procedures. The study enrolls adults with coronary artery disease who have at least o…

This trial compares two methods for closing the main artery in the leg after a TAVI procedure, which replaces a heart valve without open surgery. Half of the participants will have the artery closed with a single suture device, while the other half will receive a hybrid approach …

This trial tests whether dapagliflozin, a drug used for diabetes, can improve blood flow in the tiny vessels of the heart in people with angina (chest pain) but no blocked coronary arteries. Participants will take either dapagliflozin or a placebo daily for 180 days. The study me…

This trial is testing an experimental drug called NTS-521, given as an intravenous infusion, to see if it can help people recover better after an acute ischemic stroke. The study will include about 140 adults aged 45 to 80 who have moderate to severe weakness on one side of the b…

This trial compares two surgical implants—the Baerveldt Glaucoma Implant and the Paul Glaucoma Implant—in people with glaucoma that is not well controlled by eye drops. Both devices are tiny tubes placed in the eye to drain fluid and lower pressure. The study will track which imp…

This trial compares two ways of giving tranexamic acid, a drug that reduces bleeding, to adults undergoing off-pump coronary artery bypass surgery. Half receive the drug as a pill before surgery, while the other half get it through an IV during surgery. The goal is to see if the …

This trial asks whether people with severe aortic stenosis can safely go home the same day after a minimally invasive heart valve replacement (TAVI) instead of staying in the hospital. About 764 patients who are stable six hours after the procedure will be randomly assigned to ei…

This trial tests whether wearing a portable heart monitor for two weeks after a TAVI procedure can reduce the risk of sudden death, dangerous heart rhythms, or stroke within the following year. People who have had a successful TAVI and show certain electrical abnormalities on the…

This trial investigates whether tirzepatide, a drug approved for diabetes and obesity, can improve recovery in people who have had a severe stroke caused by a large artery blockage. Participants receive two injections of tirzepatide—one before a clot-removal procedure and another…

This trial tests whether a hybrid cardiac telerehabilitation program — combining in-person sessions, live video workouts, and remote monitoring — can improve adherence to exercise rehab in people with coronary artery disease or stable heart failure. Participants are randomly assi…

This trial tests whether angiotensin receptor blockers (ARBs), a type of blood pressure medication, can reduce the risk of death or heart failure in people who have had a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis and still have a thickened heart mus…

This trial explores whether starting transdermal estradiol (a skin gel or patch) soon after menopause can protect the heart and brain in women who have hot flashes and at least one cardiovascular risk factor. One hundred women will be randomly assigned to receive the hormone ther…

This trial is testing a new device called the Crea Aortic Valve, a replacement heart valve that can be implanted through a catheter without open-heart surgery. It is designed for people aged 60 and older with severe aortic stenosis—a narrowing of the heart's main valve—who are co…

This trial tests whether a telemedicine program can help Black patients with high blood pressure get better control. The program includes home blood pressure monitoring, medication management, and support from pharmacists, nurses, community health workers, and social workers. Res…

This study compares two ways to guide a minimally invasive procedure that opens blocked arteries below the knee in people with chronic limb-threatening ischemia, a severe form of peripheral artery disease. One group receives standard X-ray guidance (angiography) alone; the other …

This trial tests whether a 9-month program called STEP COACH can help people with coronary artery disease stay physically active after completing cardiac rehab. Participants use their own smartwatch or smartphone to track steps and receive coaching on increasing both step volume …

This study tests a new device called the Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System for people with severe tricuspid regurgitation, a condition where the heart's tricuspid valve leaks blood backward. The device is placed through a catheter, avoiding open-hear…

This study looks at whether using a smartphone app to guide slow breathing, combined with aerobic exercise, can help lower blood pressure in people with essential hypertension. Seventy-five adults aged 40-50 with stage 1-2 hypertension will be split into three groups: breathing p…

This study tests whether the drug vericiguat can slow the buildup of calcium on the aortic valve in people with mild-to-moderate aortic valve stenosis. Participants take vericiguat or a placebo daily for 24 months, with regular heart scans to track valve calcium and function. The…

People living with HIV have twice the risk of heart attacks and stroke compared to the general population. This trial tests whether integrating clinical pharmacists into HIV care can improve blood pressure control and reduce cardiovascular disease risk. The study enrolls 450 adul…

This study looks at whether a minimally invasive surgical procedure can help people with a spontaneous deep brain hemorrhage (bleeding in the basal ganglia) recover better than standard medical treatment alone. Researchers will follow 300 adults for 180 days, measuring survival, …

This phase 2b trial tests whether injecting allogeneic neural stem cells (CC-101) into the brain near a prior stroke lesion can improve motor function in adults with chronic ischemic stroke and lasting movement problems. About 36 participants will receive either stem cells plus s…

This study tracks how well the FLOWRUNNER Aspiration System removes symptomatic blood clots from veins in the arms or legs during routine care. About 218 adults with deep-vein clots will be followed to see if the device safely restores blood flow and reduces clot-related disabili…

This study investigates whether Songling Xuemaikang capsules, a traditional Chinese herbal formula, can help people with both high blood pressure (hypertension) and insomnia. About 260 adults aged 18–79 with mild hypertension and sleep difficulties will take either the herbal cap…

This study tests whether people with pulmonary arterial hypertension (PAH) who are doing well on the drug sotatercept can safely stop their background prostacyclin therapy. Prostacyclin drugs can cause side effects and are hard to manage. The trial compares patients who slowly st…

This study tests whether a patient navigator — a trained staff member who helps connect people with health services — can improve long-term heart health for those who had high blood pressure disorders during pregnancy. About 60 participants will be randomly assigned to receive ei…

This study investigates whether a standardized microsurgical procedure can safely and effectively remove large spontaneous brain hemorrhages (bleeds) located near the brain's surface. The procedure uses a microscope and computer guidance to evacuate the clot, with the goal of lea…

This trial tests whether a wearable hand robot, used at home with remote therapist support, is a feasible way to deliver intensive hand therapy to people who had a stroke at least six months ago. Participants will either use the robot for 12 weeks or receive the same amount of st…

This study tests whether a specially formulated omega-3 supplement, with a high ratio of EPA to DHA, can reduce inflammation and improve blood vessel function in people with pulmonary arterial hypertension (PAH). Participants take four capsules daily for 12 weeks alongside their …

This trial investigates whether photobiomodulation—applying low-level laser light to the surgical wound—can improve healing and reduce complications after coronary artery bypass grafting (CABG). It compares two methods of harvesting the saphenous vein (the conventional technique …

This trial tests whether an absorbable gelatin sponge works as well as cyanoacrylate glue for closing off enlarged stomach veins that can bleed. Both treatments are delivered via endoscopy with small coils. Participants are adults with a history of bleeding from these veins, and …

This study tests two experimental drugs, REGN7508 and REGN9933, to see if they can prevent blood clots in people who have a peripherally inserted central catheter (PICC). People with PICCs are at higher risk for venous thromboembolism (VTE), which can be serious. The trial compar…

This clinical trial is testing a new heart valve replacement system called Encantor, which uses software to guide placement of the valve. The study includes 150 adults with severe aortic stenosis who are candidates for a minimally invasive procedure. Researchers will track how ma…

This trial investigates whether giving two drugs—remifentanil and dexmedetomidine—soon after a spontaneous brain hemorrhage can safely lower blood pressure and improve recovery. The study includes adults with a brain bleed who have high blood pressure and are treated within six h…

This study looks at how well atogepant, a daily pill, works to prevent migraines in adults treated in UK primary care. About 200 people with migraine will take atogepant as prescribed by their doctor and report their symptoms and healthcare use for up to 48 weeks. The goal is to …

This pilot study tests whether a three-week inpatient cardiovascular rehabilitation program, started three months after abdominal aortic aneurysm repair, improves cardiorespiratory fitness more than standard post-operative care. Researchers will measure changes in maximal oxygen …

This trial tests whether a newer balloon-expandable heart valve with intermediate sizes (Myval) is as safe as a standard self-expanding valve (Evolut) in people with severe aortic stenosis whose valve measurements fall in a 'borderline' range. About 600 participants will be rando…

This trial tests whether giving a clot-busting drug directly into the brain arteries after mechanical clot removal can improve recovery in people having a severe stroke. About 1,500 adults with acute ischemic stroke who undergo endovascular thrombectomy will be randomly assigned …

This study tests whether a new drug called baxdrostat can lower blood pressure in Chinese adults whose hypertension remains uncontrolled despite taking two or more blood pressure medications. Participants receive either baxdrostat or a placebo daily for 12 weeks, while continuing…

This phase 3 trial tests whether a daily tablet of CLR-07-23 (heparan sulfate) can reduce symptoms of chronic venous disease, such as leg pain, itching, swelling, and night cramps. The study includes adults aged 18 to 80 with mild to moderate vein disease. Participants take eithe…

This study tests whether montelukast, a common allergy medication, can reduce damage to the kidneys, eyes, and blood vessels in adults with type 2 diabetes and early kidney disease. The drug works by blocking inflammatory chemicals called leukotrienes, which are linked to diabete…

This trial investigates whether patients with acute coronary syndrome can safely stop taking aspirin soon after a heart stent procedure and continue with only a potent antiplatelet drug (ticagrelor or prasugrel). The standard approach is to take both aspirin and a P2Y12 inhibitor…

This trial tests whether a sublingual (under-the-tongue) tablet of edaravone dexborneol, given within 6 hours of stroke onset during transfer between hospitals, can improve functional recovery in people with acute ischemic stroke. About 1,040 participants will receive either the …

This trial tests whether a less intensive antiplatelet therapy is safer and as effective as standard dual therapy for people with spontaneous coronary artery dissection (SCAD), a rare cause of heart attack in women aged 30–55. Unlike typical heart attacks, SCAD involves a tear in…

This pilot study tests a new catheter device designed to deliver clot-dissolving medication directly to blood clots in the lungs of adults with intermediate-risk pulmonary embolism. The goal is to see if the device can be used safely and as intended. All 20 participants will rece…

This study tests whether using a temporary heart pump (CorVad) during a procedure to open blocked arteries (PCI) can improve outcomes for people with complex coronary artery disease and a very weak heart (ejection fraction below 35%). Half of the 452 participants will receive the…

This study tests an experimental drug called REGN22530 in people with primary open angle glaucoma or ocular hypertension. The drug is designed to block a protein in the eye that causes fluid buildup and high pressure. Researchers are checking for side effects, how the drug moves …

This study explores whether applying mild electrical stimulation to the spinal cord through the skin can improve blood pressure control in people with spinal cord injury. Participants will undergo tilt-table tests to measure immediate effects, plus 20 stimulation sessions to see …

This study tests whether stroke survivors can safely use a robot called ReHandyBot to exercise their hand at home without a therapist present. Participants first learn how to use the device at a clinic, then take it home to train on their own. The goal is to see if unsupervised h…

This phase 3 trial tests whether giving clot-busting drugs directly into the blocked brain artery (intra-arterial thrombolysis) helps people recover better from a medium-vessel stroke. About 306 adults aged 18-80 with acute stroke will be randomly assigned to receive either the d…

This early study tests whether a drug called sirolimus (rapamycin), given directly into the brain's fluid spaces, can prevent hydrocephalus after a severe brain hemorrhage. Hydrocephalus is a dangerous buildup of fluid that often requires a permanent surgical shunt. The trial wil…

This study looks at whether stopping propranolol suddenly or slowly is better for preventing hemangioma regrowth in infants. About 110 children who have taken propranolol for at least 6 months will be randomly assigned to either stop immediately or taper over 4 weeks. The goal is…

This study tests whether a blood test measuring the sFlt-1/PlGF ratio can help doctors decide the best time to deliver babies in women with severe early-onset preeclampsia. The trial will include 386 pregnant women between 30 and 34 weeks of gestation. Half will have delivery tim…

This study tests whether the drug vericiguat can improve right heart function and reduce tricuspid regurgitation in 100 adults with heart failure and reduced pumping ability. Participants take vericiguat daily for 9 months, with regular heart scans and walking tests to measure ef…

This study tests whether a 12-week tele-pulmonary rehabilitation program, done at home via an app with a physiotherapist, helps people with chronic lung diseases start and stick with rehab better than going to a center. 90 patients will be randomly assigned to either remote rehab…

This pilot study tests a new device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. Twenty adults with untreated mild hypertension will either get the real procedure or a sham (fake) one. The main goal is to see if the real t…

This trial investigates whether a diet rich in polyphenols—including daily cocoa and extra fruits and vegetables—can reduce oxidative stress and improve blood vessel function in pregnant women. Researchers will randomly assign 60 pregnant women to receive dietary counseling and c…

This study tests a specially designed suction tube that cleans deep throat secretions under direct laryngoscope guidance. The goal is to see if it reduces pneumonia within 28 days in stroke patients who have trouble swallowing or coughing. Participants are adults with acute ische…

This trial tests whether a specialized scoring balloon, called Naviscore, can better prepare calcified coronary arteries before placing a drug-eluting stent. Hardened plaques often prevent stents from expanding fully, raising risks of re-narrowing or clots. About 200 adults with …

This Phase 2 trial tests whether a fixed-dose combination of leucine, sildenafil, and metformin (NS-0200) can lower blood pressure in adults aged 18 to 75 with hypertension. About 150 participants receive one of two doses of the combination or a placebo for 12 weeks. The main goa…

This study looks at whether a long-acting injectable HIV prevention drug (cabotegravir) can be delivered fairly and effectively in NHS sexual health clinics. Researchers will follow 200 people taking the drug for 12 months, along with 20 healthcare professionals, to see how well …

Many people with diabetes skip regular eye exams, even though early treatment can prevent vision loss. This pilot study tests whether offering retinal photography during routine occupational health visits makes screening easier to access. Workers with diabetes attend one visit wh…

Researchers are testing whether a smartphone app called Stethophone can help primary care doctors find moderate or severe aortic stenosis in adults aged 70 and older. The app turns a phone into a digital stethoscope and analyzes heart sounds for murmurs that may signal the condit…

Researchers are testing a soft, wearable ultrasound patch that sticks to the chest and continuously images the heart in adults and children with severe heart conditions in intensive care. The study compares heart function measurements from the patch with results from standard bed…

Researchers at Massachusetts General Hospital are studying whether molecular imaging and detailed biological profiling can predict how quickly aortic stenosis gets worse. The trial enrolls 100 adults with mild to moderate calcific aortic stenosis. Participants receive a baseline …

Researchers are testing whether a non-invasive device that reads the heart's magnetic signals can help emergency department doctors tell high-risk from low-risk chest pain. The study enrolls adults 22 and older who arrive with symptoms suggesting a possible heart attack and who f…

Acute kidney injury is a common complication after coronary artery bypass grafting. This observational study examines whether two measurements from kidney Doppler ultrasound, the renal augmented velocity index and the renal resistive index, can predict which patients will develop…

Researchers at Assiut University are studying whether two ultrasound measures of fetal heart function and blood flow can predict poor outcomes in pregnancies complicated by diabetes or preeclampsia. The study enrolls 69 pregnant women, including those with gestational diabetes, p…

Researchers are studying whether two bedside ultrasound techniques can help emergency doctors identify traumatic brain injury patients at risk of getting worse within 24 hours. The study enrolls 60 adults with acute traumatic brain injury and a low Glasgow Coma Scale score who ar…

Researchers are testing a noninvasive MRI technique that uses inhaled hyperpolarized xenon gas to measure lung function in adults with interstitial lung disease, pulmonary hypertension, and systemic sclerosis. The study includes about 51 participants, including healthy volunteers…

Peripheral artery disease narrows the vessels that carry blood to the legs, and surgery to restore flow does not always go well. Researchers at Fudan University are studying whether CT perfusion, a scan that measures blood flow in tiny vessels, can help predict which patients wil…

Researchers are checking whether an Indonesian version of the Oxford Cognitive Screen-Plus accurately measures thinking skills in people who have had a stroke. The study enrolls 75 adults who can read and speak Indonesian and are in the subacute or chronic phase after stroke. Par…

Carotid endarterectomy removes plaque from the neck artery, and surgeons clamp the artery briefly during the operation. In awake patients, doctors check hand strength and speech to decide if a shunt is needed. This study tests whether a forehead sensor that measures brain oxygen …

Researchers are testing an experimental PET imaging tracer called 18F-S2P to see how well it detects inflamed plaques in people with large-artery atherosclerosis. About 200 adults aged 40 to 80 with suspected atherosclerosis receive an intravenous dose of the tracer and then unde…

Researchers are testing whether adding organ Doppler ultrasound to standard echocardiography helps doctors better manage a common heart vessel problem in preterm infants. The trial enrolls 88 premature babies born before 34 weeks or weighing under 1800 grams. Half receive standar…

Researchers at Assiut University are investigating whether the severity of erectile dysfunction mirrors the severity of coronary artery disease in men aged 18 to 50. The study enrolls 120 men who are undergoing coronary angiography for suspected or confirmed heart conditions. Par…

Researchers at Mayo Hospital Lahore are studying whether the Surgical Apgar Score can identify patients who need direct admission to the intensive care unit after emergency abdominal surgery. The score uses three factors recorded during surgery: estimated blood loss, lowest mean …

This study will test a new type of CT scanner that uses silicon-based detectors to take detailed pictures of the heart. The goal is to see if it can provide clearer images of coronary arteries while using less radiation and contrast dye than current scanners. About 1,000 adults r…

Researchers are testing whether an open-source artificial intelligence model can measure coronary artery calcium on routine chest CT scans that were not originally taken for heart imaging. The study uses existing scans from about 1,950 people at a German hospital, including patie…

This observational study will enroll 440 Danish-speaking adults over 50 to see if an artificial intelligence model can detect dementia and mild cognitive impairment from speech recordings. Participants will complete standard cognitive tests and describe a picture while being reco…

This trial tests whether a bedside ultrasound of the eye can reliably detect raised pressure inside the skull, a condition that can damage the brain if not treated quickly. Researchers will measure the optic nerve sheath diameter in adults suspected of having high brain pressure …

This trial compares two imaging strategies—CT with CT angiography versus MRI with MR angiography—as the first test for people with suspected severe ischemic stroke. The goal is to see which approach is more cost-effective while still leading to good patient outcomes. Six hundred …

This study tests whether using an AI program to screen for diabetic eye disease during regular primary care visits can get more people to follow up with an eye specialist. It will include 4,000 adults with diabetes who have Medicaid and haven't had an eye exam in the past year. T…

This study tests whether a high-powered 7T MRI can measure sodium levels in the brain tissue around a bleeding stroke, and whether a drop in sodium predicts worse swelling and disability. Researchers will also use an AI algorithm to create similar sodium maps from standard 3T MRI…

Researchers at Assiut University are testing whether a new ultrasound measurement, the Amniotic-Umbilical-to-Cerebral Ratio (AUCR), can predict complications in newborns of women with hypertensive disorders of pregnancy. They will compare AUCR with the traditional Cerebroplacenta…

Researchers at Mayo Clinic are testing whether people who have a type 2 heart attack, without major blockages in the large heart arteries, are more likely to have disease in the tiny blood vessels of the heart. The study uses a special X-ray procedure called coronary reactivity t…

This trial tests whether a Huawei smartwatch can measure blood pressure accurately with fewer readings than the standard 24-hour monitor, which inflates a cuff every 15 to 30 minutes and often disrupts sleep. About 500 adults in Malaysia will participate, with a subgroup of 50 un…

This study tests whether a Huawei smartwatch can accurately identify adults at risk for hypertension (high blood pressure) in everyday settings. About 500 adults in Malaysia will wear the smartwatch, which uses light sensors to estimate blood pressure. A subgroup of about 50 peop…

This study tests whether a portable, radiation-free ultrasound performed at the bedside can accurately detect brain injuries in children, compared to the standard head CT scan. Researchers will enroll 220 children aged 2-17 who are already scheduled for a head CT due to suspected…

This trial tests whether an AI-guided handheld ultrasound, used during routine primary care or geriatrics visits, can detect serious heart valve disease and weak heart muscle in adults aged 65 to 85 who have no known heart problems. Half of the participants will receive this quic…

This study tests whether a computer algorithm can analyze standard EEG recordings from full-term newborns who experienced oxygen deprivation at birth to tell apart mild brain injury from moderate or severe forms. The algorithm's readings are compared against expert review of the …

This trial compares two blood-test strategies for diagnosing heart attacks in people with chest pain: the standard approach of testing at arrival and again 3 hours later, versus an accelerated approach testing at arrival and again after just 1 hour. The goal is to see whether the…

This trial tests whether two non-invasive tools can help paramedics detect dangerously high pressure inside the skull in patients with sudden brain injury, such as stroke or head trauma, before they reach the hospital. The tools are a wearable sensor placed on the head and an ult…

This trial tests whether a smartphone app called Antshrike, paired with a smartwatch, can predict heart attacks or strokes within 3-4 days in people at high risk. Participants aged 40 to 79 with existing heart disease or elevated risk will wear the smartwatch for 18 months while …

This trial tests whether a portable handheld Doppler device can help nurses quickly detect arterial insufficiency in people with diabetes who have foot ulcers. The device checks for blood flow in the great toe, and the goal is to see if it can reliably flag patients who need furt…

This trial tests whether an accelerated heart MRI scan, taking only 15 to 20 minutes, can diagnose coronary artery disease as accurately as the standard 45- to 50-minute scan. About 2,000 adults with suspected coronary heart disease will be randomly assigned to receive either the…

This study explores whether a newer type of SPECT/CT scan can accurately measure blood flow in the heart, similar to the more expensive and less available PET scan. Researchers will compare the two imaging methods in 30 adults with coronary artery disease who are already schedule…

This study tests a new ultrasound method called super-resolution ultrasound (SRUS) to see tiny blood vessels in liver tumors. Current scans show only larger vessels, but SRUS can detect vessels as small as 20 micrometers. Researchers will compare blood flow patterns in different …

This study tests whether an artificial intelligence system called AngioAI+ can accurately diagnose two types of coronary artery disease using standard angiogram images. The research involves 620 adults with suspected coronary artery disease who are already scheduled for an angiog…

This study tests whether oxygen-enhanced MRI (OE-MRI) can identify low-oxygen (hypoxic) regions in high-grade gliomas, the most common and aggressive adult brain cancers. Twenty-five patients will undergo OE-MRI scans before, during, and after standard radiotherapy. Researchers w…

Researchers are testing whether a digital program that combines a smart bracelet and a mobile app can help people who have had an ischemic stroke avoid another one. The study enrolls adults who recently had a stroke and also have high blood pressure and diabetes. Half receive usu…

Researchers are testing whether mild electrical stimulation of a nerve in the ear can prevent atrial fibrillation, a common irregular heartbeat, after off-pump coronary artery bypass surgery. Adults scheduled for this heart surgery receive either the stimulation plus standard car…

Spinal anesthesia for cesarean delivery often causes a sudden drop in blood pressure. Researchers are testing different infusion rates of phenylephrine, a drug that narrows blood vessels, to find the dose that prevents this drop in most women. The trial enrolls 200 women with ful…

Chronic pain after heart surgery through a breastbone incision affects many patients and can last for years. Researchers are testing whether an ultrasound-guided nerve block, given after anaesthesia but before the first cut, can reduce the chance of chronic pain three months late…

Researchers in South Savo, Finland, invite residents turning 45, 50 or 55 to take a blood test that measures many small molecules at once. The test estimates each person's 10-year risk of type 2 diabetes, heart attack, stroke, chronic kidney disease and fatty liver disease. Peopl…

This trial tests whether ticagrelor, an antiplatelet drug, can prevent stroke and delayed brain ischemia in people who have had a low-grade aneurysmal subarachnoid hemorrhage. Participants receive either ticagrelor or a placebo for 14 days, starting just before endovascular treat…

This study tests whether a numbing injection around a nerve cluster in the neck, given just before heart bypass surgery, can prevent a common complication called atrial fibrillation (irregular heartbeat) in the first week after surgery. About 450 adults scheduled for bypass will …

This trial tests whether a school-based program called Operation ToneUp can improve fitness, nutrition knowledge, and blood pressure in children in grades 3 through 6. Students in participating schools will complete two 20-minute web-based sessions each week during class time, fo…

This study looks at how to make HIV prevention pills (PrEP) easier for young people to get and keep using. Researchers will follow 1000 current or eligible PrEP users in Alabama and Botswana for 2 years. They will also create and test a decision-support toolkit to help patients a…

This trial tests whether an AI-driven health management program can reduce the chance of a first ischemic stroke in adults at high risk. Participants in Beijing communities will be randomly assigned to either AI-supported care or usual community health services. The AI program us…

This trial tests whether high-intensity cholesterol-lowering therapy prevents strokes and heart problems better than moderate therapy in adults with narrowing of brain arteries but no symptoms yet. Participants are randomly assigned to one of two treatment strengths and followed …

This phase 3 trial will test whether a low dose of the blood thinner rivaroxaban plus aspirin can prevent recurrent strokes better than the standard clopidogrel plus aspirin in people with narrowed brain arteries. About 1,172 participants who recently had a stroke or high-risk TI…

This trial compares two drugs, dexamethasone and ondansetron, given before spinal anesthesia for cesarean delivery in women with preeclampsia. Spinal anesthesia often causes a sudden drop in blood pressure, which can reduce blood flow to the placenta and vital organs. Researchers…

This phase 3 trial tests whether orforglipron, a daily oral medication, can help overweight adults reduce their risk of developing obesity-related complications such as type 2 diabetes, high blood pressure, and high cholesterol, as well as progression to class 1 obesity. Particip…

This trial tests whether Epidiolex, a prescription CBD medication, can delay or prevent the first seizure in infants with Sturge-Weber syndrome, a rare condition that often leads to seizures and developmental challenges. The study enrolls babies aged 1 to 18 months who have brain…

This pilot study tests a lifestyle intervention called BASIC-S, which uses coaching, text messages, and video check-ins to help people improve blood pressure, activity, sleep, social connection, nutrition, and support. The goal is to see if this approach is feasible and acceptabl…

This trial tests whether pairing women who had high blood pressure during or after pregnancy with a trained community health worker for six months can lower their blood pressure compared to usual care. Participants are randomly assigned to receive either standard care or standard…

This pilot study tests two non-invasive methods to keep the airways clear in adults who are unconscious or severely ill and need a breathing tube. One method uses a special tube with continuous low-pressure suction, and the other delivers a programmed 'artificial cough' through t…

This trial tests whether eplerenone, a drug that blocks the hormone aldosterone, can prevent the onset of high blood pressure in people aged 30–55 who have a mild, early form of primary aldosteronism but normal blood pressure. Participants will receive either eplerenone or a plac…

This trial tests whether offering a seasonal flu vaccine to heart patients while they are still in the hospital, along with active counseling, increases vaccination rates compared to counseling alone. The study enrolls adults hospitalized for acute coronary syndrome or heart fail…

This study explores whether offering HIV prevention medication (PrEP) through pharmacies can help more young women aged 18-24 in Tanzania access and consistently use it. Researchers compare four different pharmacy-based service models to standard care, and later test cost-sharing…

This study tests whether giving high-flow oxygen through special nasal prongs during a less-invasive heart valve replacement (TAVR) can prevent low oxygen levels and breathing complications. About 452 older adults undergoing TAVR under sedation will be randomly assigned to receiv…

Researchers are testing whether older adults with high blood pressure who report insomnia can improve their sleep by pressing six acupoints on themselves each night for 28 days. The trial compares this self-acupressure routine with sleep hygiene training in 94 participants aged 6…

Aortic arch surgery temporarily cuts blood flow to the brain, which can leave patients with lasting thinking and memory problems. Researchers at Seoul National University Hospital are testing whether anesthesia with remimazolam, rather than propofol, lowers the chance of that cog…

Researchers are testing whether nurse-led lessons delivered through virtual reality or a tablet help people with coronary artery disease understand their heart risks and take their antiplatelet medicines as prescribed. The trial enrolls 54 adults aged 18 to 65 who have coronary a…

Some brain tumors, including meningiomas, hemangioblastomas, and certain metastases, have a rich blood supply that makes surgical removal difficult and risky. This study tests whether blocking the tumor's feeding blood vessels with a catheter procedure before surgery reduces blee…

This trial tests whether an experimental oral drug called BR005-036C can quickly relieve migraine attacks in adults. Researchers will compare two doses of the drug against a placebo in about 2,079 people who have migraines with or without aura. The main goals are to see if the dr…

Researchers are testing a new device called the Solutio™ catheter to see if it can safely deliver numbing medicine (tumescent anesthesia) from inside the great saphenous vein before endothermal ablation, a common treatment for varicose veins. The trial enrolls 30 adults with veno…

Researchers at Emory University are testing whether a fully provided, unrefined, polyphenol-rich plant-based diet can improve blood vessel function in adults with coronary microvascular dysfunction, a condition where the heart's small vessels cannot deliver enough blood despite c…

Researchers are testing whether a structured prenatal education program based on the Roy Adaptation Model can reduce stress and improve quality of life for pregnant women with hypertensive disorders. The study enrolls 54 pregnant women between 20 and 32 weeks of gestation who hav…

This study tests whether applying mild electrical stimulation to specific acupoints on the wrist before anesthesia can prevent low blood pressure in older adults undergoing surgery. Researchers will compare high-frequency versus low-frequency stimulation in 84 participants aged 6…

Researchers are testing whether adding diaphragmatic breathing training to standard physiotherapy helps people with chronic stroke improve trunk control and postural stability. Forty adults who had a stroke at least six months earlier will be randomly assigned to either breathing…

This study tests whether using a lower-sodium dialysis fluid can improve blood pressure and blood vessel function in people with kidney failure on hemodialysis. Twenty-five participants will each receive both a low-sodium and a standard-sodium dialysis for three weeks, in random …

Researchers are testing whether a rehabilitation program that combines mental tasks with balance exercises helps stroke survivors who have hemispatial neglect, a condition where the brain ignores one side of the body or space. Participants are randomly assigned to receive either …

Infantile hemangioma is a common birthmark that can grow quickly in a baby's first months. Researchers are testing a 5% simvastatin ointment applied directly to the skin of babies aged 3 to 6 months with newly diagnosed superficial hemangiomas. The study checks whether the ointme…

This study looks at how a cannabis-based drug (Dronabinol) affects blood pressure and heart function. Researchers will measure blood pressure, heart rate, and nerve activity in 50 healthy adults aged 21-40 who use cannabis occasionally. The goal is to see if cannabis can help man…

Researchers test whether infusing lidocaine into the middle meningeal artery reduces headache severity in adults who have had a bleeding brain aneurysm. Participants receive either lidocaine or a saline placebo during their endovascular aneurysm repair. The trial measures headach…

Researchers are testing an oral drug called elismetrep (K-304) to see if it can quickly relieve moderate or severe migraine attacks. The Phase III trial enrolls about 1,500 adults aged 18 to 75 who have had migraines for more than a year. Participants receive either elismetrep or…

This study looks at whether adding a non-invasive brain stimulation technique called rTMS to standard physical therapy can help people with chronic stroke-related weakness improve their movement, balance, and quality of life. Twenty adults who had a stroke at least six months ago…

Hemorrhoidectomy often causes severe pain, and doctors use pudendal nerve blocks to help. Researchers are testing whether a block placed higher up near the ischial spine works better than one placed lower near the perineum. Adults having elective hemorrhoid surgery receive one of…

After a stroke, many people need rehabilitation to regain movement, balance, and independence, but repetitive exercises can be hard to keep up. This small Swedish study tests a mixed-reality system called RehAtt XR, which uses special glasses to project digital holograms into the…

Researchers are testing a new defibrillator lead called the Medtronic OmniaSecure Model 3930M in people who need a defibrillator and also have moderate or worse tricuspid valve regurgitation. The lead is placed through the middle cardiac vein, a different route than usual, with t…

Researchers are testing whether squeezing a stress ball during femoral arterial sheath removal after coronary angiography can reduce pain and anxiety and improve patient satisfaction. The trial enrolls 34 adults who had a stent or balloon angioplasty through the femoral artery. H…

This study tests if using a cotton-tipped applicator to hold the eyelid open during eye injections is less painful and faster than the standard metal speculum. About 120 adults with certain eye conditions will take part. The goal is to improve comfort and satisfaction without com…

Small fiber neuropathy damages tiny nerve fibers, causing severe pain that often resists standard painkillers. This trial tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive technique that sends magnetic pulses to specific brain regions, can reduce t…

This trial tests whether an 8-week lifestyle program can reduce the burden of chronic migraine, a condition marked by headaches on at least 15 days per month. Adults aged 18 to 55 with chronic migraine will be randomly assigned to either the lifestyle program or a wait-list contr…

This pilot trial tests whether a 12-week home-based exercise program, called ASK, is feasible and beneficial for postpartum women who had high blood pressure during pregnancy. The program combines aerobic exercise, strength training, and Kegel exercises, guided by a mobile app an…

This trial tests whether a 6-week prehabilitation program called Ready for Recovery can help adults prepare for aortic aneurysm repair surgery. The program includes education, health behavior support, psychological symptom reduction, and social support, with weekly phone sessions…

This trial tests whether guided imagery, a relaxation technique using audio recordings, can reduce anxiety and improve sleep and comfort in adults with acute coronary syndrome, such as a heart attack, who are in a cardiac intensive care unit. Participants will be randomly assigne…

Researchers at Yale University are testing whether cognitive behavioral therapy for migraine (CBTm) can improve quality of life for veterans with episodic migraine. The study compares CBTm, a six-session behavioral program, to a digital migraine education intervention. Participan…

This pilot study tests whether adding regular sauna sessions to usual care can help lower blood pressure in people with primary aldosteronism, a condition that causes high blood pressure. Ten adults will attend three 30-minute sauna sessions per week for two weeks while wearing a…

This study tests whether a special omega-3 supplement can reduce pain in adults with chronic temporomandibular disorder (TMD), a condition causing jaw pain. One hundred participants will take either the supplement or a placebo daily for 8 weeks. Researchers will measure changes i…

This trial tests whether a long-acting local anesthetic, liposomal bupivacaine, provides better pain relief than the standard ropivacaine when injected around the surgical site after open hemorrhoidectomy. Adults aged 18 to 60 with grade III-IV hemorrhoids will receive one of the…

This trial tests whether listening to a personalized music playlist during coronary interventional procedures can reduce anxiety and pain. About 208 adults with acute coronary syndrome will be randomly assigned to either standard care or standard care plus music through wireless …

This study is testing whether a computer-based brain training program called RehaCom Online is acceptable and feasible for young stroke survivors (aged 18-65) who are working toward returning to work. Participants will use the program for at least 30 minutes, twice a week, for fi…

This trial tests whether wearing a light-blocking eye mask at night can improve sleep quality and reduce delirium in patients recovering from coronary artery bypass graft (CABG) surgery. About 100 adults scheduled for elective CABG will wear the mask during nighttime sleep, and t…

This trial tests whether applying a numbing medicine (lidocaine) to a nerve cluster inside the nose can quickly relieve migraine headaches, facial pain, and neck pain. Adults who have frequent headaches and facial pressure will receive either lidocaine or a saltwater placebo duri…

This trial tests whether placing a small catheter near the breastbone to deliver local anesthetic can reduce pain after coronary artery bypass surgery. Half of the participants will receive this catheter-based pain relief, while the other half gets standard care. Researchers will…

This pilot trial tests whether NeuroEyeCoach, a computer-based eye movement training program, can help stroke survivors who have lost part of their visual field. Sixty participants will be randomly assigned to receive either the training plus usual care or usual care alone. The s…

This study tests an inhaled powder called LIQ861 (treprostinil) in adults with scleroderma who have frequent, painful Raynaud's attacks—episodes where fingers or toes turn color and become numb or tingly. About 75 participants will be randomly assigned to receive either a dose th…

This trial tests whether spinal cord stimulation (SCS) can reduce muscle spasticity in adults who have had a stroke. Participants will have a small device implanted that sends electrical pulses to the spinal cord. Half will receive active stimulation for six weeks, while the othe…

This trial tests whether an 8-week daily resistance exercise program can reduce chest pain and improve daily function in women who have angina without blocked coronary arteries (ANOCA). Around 76 to 152 women across 13 hospitals in the UK and Netherlands will be randomly assigned…

This trial tests whether a non-invasive device that gently stimulates the vagus nerve through the ear is tolerable for children who have had a stroke. One child will receive ear stimulation paired with occupational therapy sessions over four weeks. The goal is to see if the child…

This trial tests whether a targeted nerve block, called an adductor canal block, can reduce leg pain after coronary artery bypass grafting (CABG) when a leg vein is used as a graft. About 120 adults scheduled for CABG will receive either the block with a numbing medication or a s…

This trial investigates whether Benson Relaxation Technique (BRT), a 20-minute mind-body relaxation session, can reduce anxiety and depression in people who had an ischemic stroke 1-2 weeks earlier. Participants are randomly assigned to receive either BRT or health education twic…

This trial compares two adaptive indoor rowing seats designed for Veterans who have limited trunk stability due to spinal cord injury, stroke, or neurodegenerative conditions. Participants will try both seats during short rowing sessions, and researchers will measure trunk moveme…

This study tests whether injecting a local anesthetic near the stellate ganglion in the neck, guided by ultrasound, can improve how patients feel after heart surgery. The block temporarily calms part of the nervous system, which may reduce pain, improve sleep, and lower the risk …

This study investigates whether a device called FREMS, which delivers rhythmic electrical pulses to the legs, can improve blood flow, reduce nerve pain and numbness, and enhance quality of life in people with type 2 diabetes who have peripheral neuropathy and poor leg circulation…

This trial tests whether a fentanyl nasal spray can reduce pain during eye exams for retinopathy of prematurity (ROP) in preterm infants. About 58 babies born at or before 31 weeks will receive either fentanyl or a saltwater placebo before their routine exam, along with standard …

This study tests whether a daily herbal capsule called Nimsai Herbal can shrink hemorrhoids and reduce symptoms like pain and itching. Fifty adults with grade 2-3 hemorrhoids will take either the herbal blend or a placebo for 10 days. The main goal is to see if the hemorrhoids im…

This study tests whether an 8-session self-hypnosis program, delivered online in groups, can help adults with migraines reduce disability and improve well-being. Forty participants are randomly assigned to either the hypnosis training or a waitlist. The program teaches self-hypno…

This study tests whether having a neurologist consult via video during ambulance transport helps decide the best hospital for suspected stroke patients. About 484 adults with stroke symptoms will be randomly assigned to standard care or standard care plus a telemedicine consultat…

Researchers at Changhai Hospital are setting up a nationwide system to monitor how well devices and procedures for cerebrovascular conditions perform after they reach the market. The study plans to enroll about 2,000 adults with acute ischemic stroke, narrowed brain or neck arter…

This study is creating a large collection of blood samples and medical information from 1000 adults with or suspected of having pulmonary hypertension (PH). Researchers hope this resource will help them find new ways to diagnose and treat PH. Participants will provide a blood sam…

Researchers want to know whether CGRP, a protein involved in migraine, also affects the vestibulo-ocular reflex, the automatic eye movement that keeps vision steady when the head turns. The trial gives 80 people at the University Hospital Zurich either a single dose of atogepant,…

Researchers want to understand why most IVF embryo transfers fail to implant and what goes wrong in pregnancies complicated by preeclampsia. They will collect small tissue samples from the womb lining of up to 500 women aged 18 to 50 who are already scheduled for a diagnostic hys…

Researchers at Assiut University Hospitals are studying how often adults with multiple sclerosis also get primary headaches such as migraine and tension-type headache. About 100 patients will complete a single visit that includes a neurological exam, headache history, disability …

This study will measure normal blood clotting values in 240 children under 18 who are having surgery or a procedure with anesthesia. The goal is to establish reference ranges for the Quantra system, a device that checks how well blood clots. This information will help doctors bet…

This study will test if an AI chatbot can give helpful nutrition advice to pregnant women. About 100 women will either use the chatbot or get standard care. The goal is to see if the chatbot is easy to use and if it helps improve diet and knowledge about conditions like gestation…

Anti-VEGF injections treat conditions like diabetic macular edema, age-related macular degeneration, and retinal vein occlusion by adding fluid inside the eye, which can briefly raise eye pressure. This observational study at Assiut University follows 50 adults receiving these ro…

Researchers at Lokman Hekim University are studying how migraine affects daily life and which factors track with worse disability. About 100 adults diagnosed with primary migraine complete questionnaires on headache features, sleep quality, fatigue, neck pain, and lifestyle, plus…

This study explores whether artificial intelligence can help perform high-field whole-body MRI scans faster while keeping image quality high. Researchers will compare standard MRI sequences with AI-accelerated versions in 600 adults undergoing screening for prostate, lung, or vas…

Researchers at Assiut University Children Hospital are following 60 newborns diagnosed with pulmonary hypertension, a condition where high blood pressure in the lungs makes breathing difficult. The study collects clinical, laboratory, and heart ultrasound data to see which early …

This observational study looks at adults aged 18 to 85 with neurological conditions like stroke, Parkinson's disease, or spinal cord injury who use robotic or virtual reality tools in their rehabilitation. Researchers want to see if hope and the quality of the patient-provider re…

Doctors use anti-VEGF injections to treat retinal diseases such as age-related macular degeneration and diabetic macular edema, and patients often need these shots for years. During each injection, a small tool holds the eyelids open, stretching the upper lid. Researchers want to…

Researchers at Chulalongkorn University are running an online survey of about 500 transgender adults in Thailand to learn how common headaches and migraines are in this group. Participants answer questions about their headache symptoms, disability, and use of gender-affirming hor…

This study will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brains of 100 people who had a stroke and underwent endovascular therapy (clot removal). The goal is to see if TCD readings can predict complications like bleeding or brain swelling in the days…

Heparin-induced thrombocytopenia (HIT) is a rare immune reaction that makes heparin dangerous, yet heart bypass surgery normally depends on heparin to keep the machine from clotting. Doctors at 11 French cardiac surgery centers are reviewing past cases where patients with confirm…

This study is testing whether a deep-learning computer model can predict, from a CT scan taken before surgery, which patients will develop a type II endoleak and aneurysm enlargement after endovascular aneurysm repair (EVAR). The model is being developed using data from multiple …

This study aims to create a version of the Mini-Mental State Examination (MMSE) that works better for people in Reunion Island. The current French version has questions that don't fit local culture. Researchers will test 400 people aged 60-89, both healthy and those with Alzheime…

Researchers are studying whether the Evolut FX Plus replacement heart valve allows doctors to reach the coronary arteries after a TAVI procedure. The trial enrolls about 122 people aged 65 and older with severe aortic stenosis. Right after the valve is implanted, doctors try to t…

This early-stage trial is asking whether two medications—one for blood pressure and one for cholesterol—can be safely taken together without affecting how each works. Healthy adult volunteers will receive each drug alone and then both together, so researchers can compare drug lev…

This study looks at people aged 65 and older who have signs of brain blood vessel disease on a past scan but no history of stroke, dementia, or other major brain conditions. Researchers will collect information on daily function, thinking skills, speech, and any new vascular even…

This study looks at how blood test results change after delivery in people with severe preeclampsia. Participants are randomly assigned to receive magnesium for either 12 or 24 hours after birth. The goal is to see if a shorter treatment is safe and effective, and to understand h…

Pulmonary hypertension often goes undiagnosed for a long time because early symptoms are vague. Researchers at Assiut University Heart Hospital are studying whether a longer delay before diagnosis is linked to more advanced disease when patients first present. The study will revi…

Researchers are observing patients in China who have both a tumor in the sellar region of the brain and an unruptured intracranial aneurysm. The study compares three approaches: removing the tumor before treating the aneurysm, treating the aneurysm before removing the tumor, or r…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study tests whether sending an electronic letter to people with heart disease and high cholesterol encourages them to get their cholesterol checked. Researchers will compare those who receive the letter to those who don't, using national health records to track results. The …

This study looks at whether mindfulness-based stress reduction can help Black teenage girls who have been involved with the justice system and their parents or caregivers. About 90 participants will report on stress, PTSD symptoms, and other outcomes before and after the program.…

This study looks at older adults over 65 who are hospitalized after a stroke in a specialized geriatric neurovascular unit in France. Researchers will collect detailed health data, including age, other medical conditions, stroke type, and complications, to describe this populatio…

This study looks at whether a one-week stay at sea level helps people with pulmonary arterial hypertension (PAH) who live permanently above 2600 meters. Researchers will measure lung function, blood oxygen, and sleep quality before, during, and after the descent and re-ascent. Th…

Researchers are testing whether a one-week stay at sea level improves walking ability and blood oxygen in people with pulmonary arterial hypertension who live permanently above 2600 meters. The study compares these patients with healthy controls from the same altitude, measuring …

This observational study will use advanced imaging techniques to measure changes in the retina and choroid (the layer beneath the retina) in people with eye diseases and healthy volunteers. Over 5 years, researchers will track thickness and blood vessel density to better understa…

This study asks whether pregnant women at high risk for preeclampsia understand the condition, its warning signs, and its risk factors. Researchers will interview 160 women at Sohag University Hospital using a standardized questionnaire. The goal is to identify gaps in knowledge …

This study will use heart scans and blood tests to check for early signs of heart disease in 650 adult survivors of childhood cancer. The goal is to better understand who is at highest risk due to past cancer treatments like radiation or chemotherapy. Results will be compared to …

This trial asks whether a one-week stay at sea level can lower blood pressure in the lungs of people with pulmonary arterial hypertension who live permanently above 2600 meters. Researchers will compare heart and lung measurements taken at high altitude with those taken after sev…

This study looks at what happens when people with pulmonary arterial hypertension, a condition that raises pressure in the lung's blood vessels, travel from their homes above 2600 meters down to sea level for a week, and then return. Researchers will measure heart rate variabilit…

Researchers are studying what happens when people with pulmonary arterial hypertension who live above 2600 meters spend a week at sea level. The trial compares their sleep, blood oxygen, and breathing during sleep at altitude and after seven days at sea level. It includes both pa…

Researchers are testing whether blood levels of a protein called asprosin are higher or lower in people with Behçet disease, and whether those levels match how active the disease is. The study will enroll 44 adults who meet the international criteria for Behçet disease. No treatm…

This study builds a registry of 400 women who have angina, or chest pain, even though their coronary arteries are not blocked. Doctors call this condition ANOCA, and it is more common in women than men, yet it has been under-studied. The registry will categorize different subtype…

This study tests whether ultrasound of the optic nerve sheath, a marker of brain pressure, can track brain swelling during ascending aortic surgery. Researchers will measure the optic nerve sheath diameter before, during, and after surgery in 134 adults undergoing this procedure.…

Doctors in the ICU often check blood gases through an arterial line, but that carries risks like clots and infection. This study asks whether blood drawn from a central venous line, which is already in place for other care, gives equally useful information. Researchers will compa…

This study looks at whether a specific heart ultrasound measurement, called left atrial reservoir strain, can better predict serious heart problems within 6 months after a non-ST-elevation heart attack (NSTEMI). Researchers will measure this strain in 150 patients and compare its…

Researchers are studying whether a quick head-turning test, called video head impulse testing, can detect subtle differences in inner ear balance function in people with vestibular migraine. The study compares 30 people with the condition to 30 healthy volunteers. Each participan…

This study gathers real-world data from medical records of patients with complex vascular anomalies treated with targeted therapies like mTOR inhibitors, MEK inhibitors, or PI3K inhibitors. Researchers will look at patient characteristics, treatment patterns, and side effects acr…

This study investigates how stroke affects arm swing during walking and whether real-time virtual reality feedback can help improve it. Researchers will measure muscle activity and movement in both stroke survivors and healthy adults to understand the differences. Participants wi…

This trial tests whether eplerenone, a drug already approved for other conditions, lowers eye pressure in healthy adults. Researchers will compare eplerenone with a placebo in a crossover design, where each participant takes both treatments at different times. Eye pressure is mea…

This study investigates whether the speed at which blood sugar falls after starting a new diabetes medicine affects small blood vessels in the eye. Adults with type 2 diabetes who are beginning a GLP-1 receptor agonist or an SGLT2 inhibitor will undergo advanced eye scans and blo…

This study will test whether wearing a magnet helmet every day can change brain inflammation linked to migraines. Ten adults with migraines will use the helmet and have brain scans before and after the treatment period. Researchers will also track migraine symptoms through questi…

Severe brain injuries can leave people in a coma or with limited awareness, and doctors struggle to predict who will recover. This study tests whether brain activity during sleep, measured with EEG, can forecast how quickly a patient wakes and how well they recover over a year. R…

This study follows 75 older adults having elective heart surgery to understand why some recover quickly while others face complications like delirium or slow recovery. Researchers will measure frailty, physical and mental function, and a blood marker of biological stress called G…

This pilot study tests whether a low-load resistance exercise program for the lower legs can improve blood flow and oxygen use in the calf muscles of people with pulmonary arterial hypertension (PAH). Participants will do the exercises for 12 weeks, and researchers will measure o…

This study looks at how renal denervation, a minimally invasive procedure for hard-to-treat high blood pressure, affects kidney function shortly after and up to a year later. Researchers will measure kidney function and analyze blood and urine samples from 50 adults with resistan…

This observational study follows people with obesity-related heart failure to see how their heart performs during exercise, using stress echocardiography. It observes those who are taking GLP-1/GIP receptor agonists (like semaglutide or tirzepatide) as part of their routine care,…

This study explores whether ultrasound measurements of the eye can detect changes in brain pressure during laparoscopic gallbladder surgery. The surgery uses carbon dioxide gas to inflate the abdomen, which may affect pressure inside the skull. Researchers will compare two differ…

This study investigates clonal hematopoiesis, an age-related condition where blood stem cells acquire mutations, and how it triggers inflammation linked to heart disease. Researchers will compare immune cells from healthy people, those with high-risk mutations, and patients with …

This study investigates whether tiny particles called extracellular vesicles, released by brain cells into the blood, can serve as reliable markers of nerve damage in people with multiple sclerosis or stroke. Researchers will measure these particles in blood samples from 60 parti…

This study is a large international registry that will look back at the medical records of about 1,000 adults who were treated with the AngioVac system, a device that uses suction to remove blood clots, infected tissue, or other unwanted material from the heart and major blood ve…

This study aims to develop and validate a questionnaire called the ProChange scale, designed to measure the barriers and facilitators to lifestyle changes in people at risk for chronic diseases. The scale will be tested in adults aged 45 and older who receive prevention advice on…

This study is a large, real-world registry that will include over 10,000 people with coronary artery disease from more than 50 hospitals across China. The goal is to see how often a software tool called QFR, which analyzes angiogram images to guide treatment decisions, is used in…

This study aims to build a specialized AI model, called CorAI, for coronary artery disease (CAD). Researchers will collect de-identified medical data from about 640 patients with suspected or confirmed CAD to create a rich dataset. Using this data, they will develop and test CorA…

This study looks at stroke survivors who have mild aphasia—a condition causing language difficulties. Researchers want to see if these individuals also struggle with 'executive control' of language, which helps us manage and switch between words and ideas. By testing 30 participa…

This study is a large, observational registry in Türkiye that will track the real-world practice and outcomes of a procedure called percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) — a complete blockage of a coronary artery that has been present for at l…

This study uses imaging scans to measure the size and blood flow speed in three key arteries—the carotid, renal, and femoral—in adults with high blood pressure. The goal is to see how hypertension affects these blood vessels, both structurally and functionally. By comparing measu…

This study tests whether a small implanted sensor, called CardioMEMS, can continuously track blood pressure in the lung arteries after surgery for chronic thromboembolic pulmonary hypertension (CTEPH). The surgery, called pulmonary endarterectomy, can cure CTEPH, but some patient…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study looks at whether inflammation levels differ on either side of a blood clot in the brain during a stroke treatment called mechanical thrombectomy. Researchers will compare blood samples taken from before and after the clot to see if the difference is linked to how well …

This study explores whether ultrasound can reliably measure aneurysms in the descending thoracic aorta, the part of the main artery that runs through the chest. Researchers will compare ultrasound measurements with standard CT scans in about 60 adults, including some with known a…

This study reviews existing research to understand how aldosterone, a hormone that regulates blood pressure, contributes to hypertension. It looks at the proteins and genetic factors involved in aldosterone production and how the body's signals might be able to block its effects.…

This study asks whether nurses in geriatric departments have the knowledge needed to properly screen for orthostatic hypotension—a sudden drop in blood pressure when standing that can cause falls and other serious problems in older adults. About 30 nurses will complete a question…

After a severe brain injury, some patients survive but cannot communicate, and it is difficult to predict who will recover consciousness. This observational study in Cyprus is testing whether a brain-wave monitoring technique called the bispectral index (BIS) can improve predicti…

This study tests whether occlusal splints (night guards) made using a fully digital workflow are as comfortable and effective as those made with a traditional wax bite registration. Healthy volunteers aged 18 to 45 will wear both types of splints overnight for three weeks each. T…

This study uses a special eye scan called OCTA to examine how blood sugar control relates to tiny blood vessel changes in the retinas of people with diabetic retinopathy. Researchers will compare patients with well-controlled and poorly controlled blood sugar levels. The goal is …

This study tests a personalized, digitally supported prehabilitation program for adults waiting for elective cardiac surgery. Participants receive education, psychosocial support, nutritional advice, and home-based exercise guidance during the routine 6-10 week preoperative perio…

This study investigates why some people develop long-term thinking and memory problems after surgery to repair a ruptured brain aneurysm. Researchers will review past medical records and then bring in 150 adult survivors for brain scans and cognitive tests. The goal is to identif…

This study tests whether measuring the optic nerve sheath diameter — the nerve that connects the eye to the brain — with a simple bedside ultrasound can predict a dangerous rise in brain pressure when a pressure-lowering drug (mannitol) is reduced or stopped. Researchers will fol…

This pilot study is investigating how quickly C-reactive protein (CRP), a key marker of inflammation, drops after starting steroid treatment in people newly diagnosed with giant cell arteritis. By measuring CRP levels daily, then weekly and monthly for up to a year, researchers h…

This study looks at whether a routine blood test measuring D-dimer levels can predict if the immunotherapy drug cemiplimab will control advanced cutaneous squamous cell carcinoma. Researchers will follow 116 patients starting cemiplimab in regular care, comparing disease control …

This study investigates whether erectile dysfunction (ED) in men being treated for high blood pressure is linked to a hidden heart condition called subendocardial ischemia, where the heart muscle doesn't get enough oxygen. Researchers will compare a noninvasive heart test called …

This observational registry study follows 2,250 adults with cardiovascular-kidney-metabolic syndrome (CKMS) at five hospitals in India. Researchers aim to understand how the condition progresses over 12 months, how it affects quality of life, and what treatments doctors prescribe…

This study looks at how tiny particles called extracellular vesicles travel through the bloodstream in people with systemic sclerosis, an autoimmune disease that affects blood vessels and organs. Researchers will take blood samples from different points in the circulation to see …

This observational study looks at whether heart rate variability — a measure of the nervous system's control over the heart — is linked to how well people with resistant hypertension take their medications. Researchers will use a blood test to objectively check drug levels and co…

This study looks at how well the right side of the heart works with the lungs in people who have high blood pressure in their lung arteries caused by schistosomiasis, a parasitic infection common in parts of Africa and South America. Researchers will use echocardiography to measu…

This study looks at children with Von Hippel-Lindau (VHL) disease, a rare genetic condition that causes tumors in the brain and spinal cord. Researchers want to understand how these tumors grow over time and what factors predict when a child will need surgery. By reviewing medica…

This study investigates genetic and molecular markers in pregnant women with severe preeclampsia, a dangerous condition involving high blood pressure and organ damage. Researchers will analyze blood, urine, and placental samples from 100 women to identify changes in genes and cel…

Superficial vein thrombosis (SVT) is a painful but usually harmless blood clot just under the skin. However, about 4% of people develop more serious clots in deep veins or lungs. Current guidelines recommend ultrasound scans to decide if blood thinners are needed, but scans are o…

This study investigates whether biomarkers in tear fluid can help diagnose migraine and monitor response to anti-CGRP therapies. Researchers will compare tear and blood samples from 400 people with migraine and healthy controls. A subgroup will be followed over time to see how bi…

This study tracks how a pregnant person's heart and lungs change over the course of pregnancy and after childbirth. Researchers will use non-invasive tests to measure blood flow and airway function, aiming to understand how these changes relate to the development of preeclampsia,…

This study tests whether four popular AI chatbots — ChatGPT, DeepSeek, Gemini, and Claude — can correctly classify surgical risk using anonymous patient vignettes. Researchers compare the AI's risk scores to those given by a panel of senior anesthesiologists. If successful, AI co…

This study follows adults with severe, treatment-resistant migraines to see if preventive treatments—like Botox injections or Eptinezumab infusions—improve not only headache frequency but also cognitive skills such as attention and memory. Researchers will assess participants' th…

This study tests whether wearable devices and artificial intelligence can help personalize the timing of valve replacement in people with moderate to severe aortic stenosis who have no symptoms. Participants wear a smartwatch to track heart rate, activity, and blood pressure, and…

This study tests whether blood pressure readings taken over different layers of clothing are as reliable as those taken on bare skin. Researchers will compare measurements from 161 emergency department patients. The goal is to see if clothing affects accuracy, which could change …

This study will follow 150 infants with a type of birthmark called infantile hemangioma. Some have a less active form that barely grows, while others have the typical form. Doctors will assess each baby using standard guidelines and decide whether to recommend treatment or just w…

This study screens adults aged 18 and older in suburban and peri-urban areas of Faisalabad, Pakistan, for four major noncommunicable diseases: diabetes, hypertension, obesity, and high cholesterol. Participants who are found to have these conditions are referred to doctors for st…

This study investigates the role of the Sonic Hedgehog signaling pathway in brain arteriovenous malformations (AVMs), abnormal tangles of blood vessels that can cause bleeding or stroke. Researchers will analyze leftover brain tissue from 20–30 adults undergoing AVM surgery and c…

This study follows 25,000 people referred to a specialized heart clinic with symptoms like chest pain or shortness of breath. Researchers will track which heart conditions are actually diagnosed and how patients are evaluated. The goal is to improve diagnostic accuracy and unders…

This study looks at why people with end-stage kidney disease on dialysis often develop high blood pressure in the lungs (pulmonary hypertension). Fluid buildup can make this condition seem worse than it is. Researchers will first correct fluid levels, then use heart ultrasound an…

This study will follow 5,500 first-time pregnant women to see if blood tests and eye scans can predict complications like preeclampsia, fetal growth restriction, and gestational diabetes. Researchers will collect samples and images at different points during pregnancy and compare…

This study will check blood pressure and ask about health habits in 500 adults who attend free public health screenings in Croatia. Researchers want to see how many people have high blood pressure, how many know they have it, and how many are taking medicine for it. No treatments…

This trial tests an AI tool called MIDI that quickly spots problems in brain MRI scans. The goal is to see if it helps doctors report urgent scans faster, so patients get treatment sooner. Over 100,000 adults will take part across multiple NHS sites in the UK.

This study looks at people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, to better understand their risk of serious heart problems like stroke and heart attack. Researchers will collect information on therapy, disease activity, lifestyle…

This study will test whether using ultrasound to guide how a patient's head is tilted can improve blood flow to the brain. Researchers will measure brain pressure and blood flow in 30 ICU patients as they are moved from lying flat to a 30-degree angle. The goal is to find a perso…

This study checks whether an Apple Watch Series 9 can accurately measure key health indicators—like oxygen levels and exercise capacity—in adults with heart conditions such as congenital heart disease, heart failure, or coronary artery disease. Participants wear the smartwatch du…

This study tests a decision aid for people who have had a first blood clot and must decide whether to stop or continue blood thinners after at least 3 months of treatment. The aid provides balanced information on risks and benefits and helps clarify personal values. Researchers w…

This study will measure certain proteins in the blood of people who have had a brain hemorrhage (bleeding in the brain) and compare them to healthy volunteers. The goal is to see if these proteins are linked to inflammation after the bleed. No drugs or treatments are being tested…

This study looks at how the sedative dexmedetomidine affects the smallest blood vessels in people with septic shock, a life-threatening condition caused by severe infection. Researchers will measure blood flow in the tongue's tiny vessels and other key blood pressure indicators b…