Could a simple dialysis tweak lower blood pressure?

NCT ID NCT07459348

Symptom relief Sponsor: Gødstrup Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Sep 16, 2026 · Updated 2 times

Summary

This study tests whether using a lower-sodium dialysis fluid can improve blood pressure and blood vessel function in people with kidney failure on hemodialysis. Twenty-five participants will each receive both a low-sodium and a standard-sodium dialysis for three weeks, in random order, acting as their own control. The main goal is to see if the lower-sodium fluid reduces 24-hour blood pressure and improves symptoms like thirst and fatigue.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Low-sodium dialysate (133 mmol/L) compared to standard-sodium dialysate (139 mmol/L)
What this could lead to: If it works, this could point toward a simple, cost-effective way to improve blood pressure and reduce symptoms like thirst and fatigue for people on dialysis.
What could go wrong: This is a very small, early-stage study with only 25 participants. Lowering sodium too much can cause dizziness, cramps, and low blood pressure during treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 25 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults receiving chronic in-center hemodialysis at Regional Hospital Gødstrup * Age ≥ 18 years * On thrice-weekly hemodialysis for a stable period (as assessed in EPJ) * Plasma sodium within the range required for safe participation (as per screening) * Able to understand study information and provide written informed consent * Eligible based on review of electronic patient record (dialysis duration, frequency, age, p-sodium) Exclusion Criteria: * Significant cardiac disease that may interfere with participation, including: * Heart failure (with clinically relevant instability) * Recent acute myocardial infarction (date verified in EPJ) * Pacemaker (specific types that interfere with measurements) * History of stroke or TCI (date verified in EPJ) * Amputation of an extremity (affects body composition measurements) * Diabetes with unstable glycemic control or recent major treatment changes * Any condition that prevents accurate blood pressure measurement or CO-rebreathing * Inability to complete study procedures (questionnaires, monitoring, blood sampling) * Expected inability to complete both intervention periods (e.g., planned transfer, transplantation) * Declines participation after receiving oral and written information

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Conditions

The condition(s) this trial relates to.

end stage renal failure Hypernatremia hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dialysis dependent chronic kidney disease Dialysis patients High blood pressure Sodium excess

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Could a simple dialysis tweak lower blood pressure?

What the study statuses mean