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Lifting weights, lifting hearts: can resistance training soothe angina in women?

NCT ID NCT07733986

Symptom relief Sponsor: NHS Greater Glasgow and Clyde Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests whether an 8-week daily resistance exercise program can reduce chest pain and improve daily function in women who have angina without blocked coronary arteries (ANOCA). Around 76 to 152 women across 13 hospitals in the UK and Netherlands will be randomly assigned to start the program immediately or after a waiting period. The study focuses on a condition that is more common in women and has few proven treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a daily resistance exercise program for 8 weeks
What this could lead to
If it works, this could offer a non-drug option to reduce angina symptoms and improve quality of life for women with ANOCA.
What could go wrong
This is a relatively small trial (76–152 women) testing an exercise program that requires daily commitment, so adherence may vary and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 76 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jun 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Angina with no obstructive coronary arties (ANOCA) 2. Myocardial perfusion reserve or coronary flow reserve recorded within three years 3. Seattle Angina Questionnaire frequency score ≤60 4. Duke Activity Status Index ≤34 5. Female sex Exclusion Criteria: 1. Age \<18 years 2. Unable to provide informed consent 3. \- Unable to comply with the protocol 4. Pregnancy 5. Currently undertaking resistance exercise activities

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Conditions

The condition(s) this trial relates to.

Angina Pectoris cardiovascular disorder coronary microvascular disorder nonobstructive coronary artery disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Angina patients with non-obstructive coronary artery disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    11 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Basildon University Hospital

    Basildon, United Kingdom

  • Brompton Hospital

    London, United Kingdom

  • Freeman Hospital

    Newcastle upon Tyne, United Kingdom

  • Guy and St Thomas Hospital

    London, United Kingdom

  • Kings College Hospital

    London, United Kingdom

  • Leeds General Infirmary

    Leeds, United Kingdom

  • Nottingham City Hospital

    Nottingham, United Kingdom

  • Queen Elizabeth University Hospital Clinical Research Facility

    Glasgow, G51 4TF, United Kingdom

  • Royal Papworth Hospital

    Cambridge, United Kingdom

  • Royal United Hospital Bath

    Bath, United Kingdom

  • Sunderland Royal hospital

    Sunderland, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.