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Emergency room care plus Follow-Up: a new strategy to tame severe high blood pressure?

NCT ID NCT07777237

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This trial tests whether a team-based care program, initiated in the emergency department, can help adults with severely elevated blood pressure achieve better control. Participants are randomly assigned to either the team-based program or usual care. The team-based program includes prompt medication prescribing, a home blood pressure monitor, virtual pharmacist support, and community health worker guidance over six months. The main goal is to see if this approach lowers systolic blood pressure at six months compared to standard care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Emergency department-initiated team-based care, including guideline-based medication prescribing, home blood pressure monitoring, virtual pharmacist management, and community health worker support
What this could lead to
If effective, this approach could offer a practical way to improve blood pressure control and reduce complications in people with severe hypertension.
What could go wrong
The trial is early and the intervention is complex, so results may vary. It may not be widely applicable or show a clear benefit over usual care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 700 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Jun 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18 through 85 years. 2. Two or more emergency department blood pressure measurements with systolic blood pressure \>=180 mm Hg or diastolic blood pressure \>=110 mm Hg. 3. History of episodic hypertension management, defined as evidence that hypertension care has been intermittent, fragmented, or primarily reactive rather than supported by stable longitudinal outpatient management. This includes one or more of the following: recurrent ED or urgent care visits for elevated blood pressure or blood-pressure-related concerns; no established primary care clinician or usual source of care; no documented outpatient hypertension follow-up; no recent antihypertensive medication initiation, adjustment, or titration despite persistently elevated blood pressure; or, for a person without a formal hypertension diagnosis, at least two prior healthcare encounters with blood pressure \>160/90 mm Hg. 4. Verbal fluency in English. 5. The treating clinician expects discharge rather than inpatient admission and does not identify hypertensive emergency syndrome, acute target-organ injury requiring inpatient care, or another condition requiring admission or alternative immediate management. Exclusion Criteria: 1. Hypertensive emergency syndrome, acute target-organ injury requiring inpatient care, an acute cardiovascular, neurologic, or renal condition requiring immediate inpatient or procedural management, or any other need for hospital admission. 2. Unable to verbalize comprehension of the study or complete the teach-back consent process. 3. Pregnant or planning to become pregnant during the next year. 4. Severe blood pressure elevation suspected by the treating clinician to be primarily due to uncontrolled pain or anxiety; the person may be reassessed after symptom control. 5. Standardized research blood pressure below 140/90 mm Hg. 6. Stage 3B chronic kidney disease or estimated glomerular filtration rate below 45 mL/min/1.73 m2. 7. Severe blood pressure elevation thought to be due to secondary hypertension, medication effect, or drug or stimulant use requiring a different management pathway. 8. Excessive alcohol use, defined as 21 or more drinks per week for men or 14 or more drinks per week for women. 9. Systolic heart failure with known left ventricular ejection fraction below 40%. 10. Prior transplant of any type. 11. Major psychiatric disorder, dementia, or another condition that in the investigator's judgment would make participation unsafe or impractical. 12. Inability or unwillingness to perform home blood pressure monitoring according to protocol. 13. Currently prescribed four or more antihypertensive medications. 14. Any other condition that, in the investigator's judgment, would compromise participant safety, informed consent, or data integrity.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Henry Ford Hospital Emergency Department

    Detroit, Michigan, 48202, United States

  • Henry Ford Medical Center - Fairlane Emergency Department

    Dearborn, Michigan, 48126, United States

  • Henry Ford St. John Hospital Emergency Department

    Detroit, Michigan, 48236, United States

  • Henry Ford Wyandotte Hospital Emergency Department

    Wyandotte, Michigan, 48192, United States

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