Henry Ford Health System

This early-stage study tests a combination of two drugs (sacituzumab govitecan and capecitabine) in people with advanced gastrointestinal cancers that have stopped responding to standard treatments. The main goal is to find a safe dose and see how well the body tolerates it. Abou…

This study compares standard rotator cuff surgery to surgery plus a bioinductive implant that may help the tendon heal better. About 78 adults with full-thickness tears will be followed for one year. The main goal is to see if the implant leads to fewer retears on ultrasound.

This study compares two types of radiation therapy for people with liver cancer (hepatocellular carcinoma). One method delivers tiny radioactive beads directly to the tumor's blood supply, while the other uses focused external beams. The goal is to see which approach better contr…

This study tests whether budesonide, a steroid often used for asthma, can prevent fevers caused by engraftment syndrome after a stem cell transplant. About 110 adults with blood cancers will receive the drug starting five days after their transplant. The goal is to see if it redu…

This early-stage study tests whether adding a drug made from urine (uhCG/EGF) to standard care can safely prevent graft-versus-host disease (GVHD) in stem cell transplant patients. GVHD is a serious condition where donor cells attack the patient's body. The study involves 18 adul…

This study looks at how well and how safely the Tigertriever device works to remove blood clots from large brain blood vessels in people having an ischemic stroke. About 150 adults will be treated within 8 hours of their first symptoms. The goal is to restore blood flow and impro…

This early-phase study tests a new approach for people with recurrent high-grade astrocytoma, a serious brain cancer. Participants receive a virus-based gene therapy injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the safest…

This study tests whether using portable air cleaners at home after a heart failure hospital stay can improve heart health. 400 adults will receive either a real air cleaner or a sham device for 90 days. Researchers will measure changes in a heart stress marker (NTproBNP) and trac…

This study is for people with blood cancers who need a stem cell transplant but don't have a perfectly matched donor. It uses stem cells from a half-matched family donor along with special drugs to help the body accept the new cells and prevent complications. The main goal is to …

This study tests whether a low dose of the drug azacitidine can help maintain or increase the level of donor cells in patients with certain blood cancers (MDS, AML, CMML, MPN) after a stem cell transplant. The goal is to reduce the chance of the cancer coming back. About 43 adult…

This study is testing whether a drug called 5-ALA, already used in brain surgery, can make upper urinary tract tumors glow under blue light during a procedure called ureteroscopy. About 10 adults with known or suspected upper tract urothelial cancer will take 5-ALA before surgery…

This study aims to reduce heart-related health problems in Detroit and Cleveland by using community health workers to help people manage high blood pressure and prevent heart failure. About 364 adults with high blood pressure or other heart risks will receive coaching and support…

This study tests a mindfulness-based sleep program for pregnant women with insomnia to see if it can prevent depression during and after pregnancy. About 500 pregnant women will either take the program or receive standard care. The goal is to improve sleep and reduce the risk of …

This study compares a nonopioid pain control regimen to standard opioid painkillers in 75 adults after clavicle fracture surgery. The goal is to see if the nonopioid approach controls pain just as well while reducing opioid risks. Participants are randomly assigned to one of two …

This study looks at how long symptom relief lasts after a corticosteroid injection in people with carpal tunnel syndrome who have normal or mild nerve test results. Researchers will review past data from 300 patients who received the injection and filled out a questionnaire about…

This study compares two types of prostate cancer surgery: the standard radical prostatectomy and a newer precision prostatectomy that aims to spare nerves and tissues. About 160 men with low- or intermediate-risk prostate cancer will be randomly assigned to one surgery. The goal …

This study tests a mobile app called SHIFT that gives personalized light and sleep advice to night shift workers. Researchers want to see if using the app improves sleep, health, and job satisfaction. About 300 people who work at least 4 night shifts per month and have poor sleep…

This study looks at ways to help people complete an online program for insomnia called digital cognitive behavioral therapy (dCBT-I). Researchers will track 600 adults with insomnia to see what factors—like sleep environment or daily habits—affect whether people finish the progra…

This study tests a special cooling mouthpiece used during radiation therapy for larynx cancer. The goal is to see if cooling the mouth can prevent or reduce taste loss, a common side effect of radiation. About 15 adults with advanced larynx cancer will try the device and report c…

This early study tests whether tranexamic acid, a drug used for heavy bleeding, can reduce dark patches in two rare skin conditions: lichen planus pigmentosus and ashy dermatosis. Researchers will enroll 5 adults and measure pigment changes with special devices. The goal is to se…

This study looks at whether a short educational session can increase the number of Black men with aggressive prostate cancer who get genetic testing. About 50 men will take part. The goal is to see if learning more about genetic testing helps them decide to get tested, which coul…

This study aims to create a computer model that can predict body temperature changes during a special type of heated chemotherapy surgery called HIPEC. Researchers will collect temperature data from 30 adults undergoing HIPEC for abdominal cancer. The goal is to better understand…

This study looks at why some night shift workers develop Shift Work Disorder (trouble sleeping and feeling very sleepy). Researchers think that being sensitive to stress (called sleep reactivity) might be a main cause, even when the body's internal clock is fixed. They will test …

This study looks at whether giving people with alcohol-related liver disease personalized options for alcohol treatment helps them actually start treatment and clears up any wrong ideas they may have. About 268 adults from University of Michigan clinics or hospitals will take par…

This study aims to improve how sleep is measured for people who work night shifts. Current sleep trackers often fail to accurately detect daytime sleep. Researchers will use multiple sensors and machine learning to create a more precise method. About 100 nightshift workers will w…

This study looks at whether two blood markers, CXCL9 and EASIX, can predict severe acute graft-versus-host disease (GVHD) in people receiving a stem cell transplant for blood cancer. Researchers will follow 100 adult patients to see if these markers can give an early warning. The…

This study aims to find the best time during a routine pregnancy ultrasound to measure the cervix, which helps predict preterm birth risk. About 550 pregnant individuals will be randomly assigned to have their cervical length measured either at the start or end of their anatomy s…

This study looks at whether sharing information between jails and health systems can help prevent suicide in people after they are released from jail. Researchers will combine jail release records with electronic health records to identify those at risk and connect them to proven…

This study is looking at how antibiotics given during a stem cell transplant affect the bacteria in your gut. Researchers will track changes in the microbiome over time in 255 adults aged 18-80 who are getting a stem cell transplant for blood cancer or bone marrow failure. The go…