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Can big data unlock the secrets of opening blocked heart arteries?

NCT ID NCT07761624

Knowledge-focused Sponsor: Ahmet Seyfeddin Gürbüz Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This study is a large, observational registry in Türkiye that will track the real-world practice and outcomes of a procedure called percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) — a complete blockage of a coronary artery that has been present for at least three months. Researchers will collect detailed data on patient characteristics, procedural techniques, and in-hospital complications from thousands of adults undergoing this procedure at multiple centers. The goal is to understand what factors are associated with successful and safe CTO revascularization, which could help improve future treatment approaches.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this registry could reveal which techniques and patient factors lead to safer, more effective procedures for opening chronically blocked heart arteries, potentially improving future treatment guidelines.
What could go wrong
As an observational study, it cannot prove cause and effect. The results may be influenced by differences in how participating centers perform procedures, and the large size does not guarantee that findings will change practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 70,000 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Jul 2036

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of consecutive adult patients undergoing attempted PCI for coronary chronic total occlusion (CTO) at participating centers in Türkiye. Both successful and unsuccessful procedures will be included. Repeat CTO PCI attempts and procedures involving different CTO lesions in the same patient will be eligible. Each procedural episode will be recorded separately and linked to the same patient using a unique study identifier, allowing patient-level and procedure-level analyses.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * Presence of at least one coronary chronic total occlusion (CTO), defined as a coronary artery lesion with TIMI grade 0 antegrade flow and an estimated duration of occlusion of ≥3 months * Undergoing an attempted PCI of the CTO at a participating center during the study period * Provision of informed consent when required by the applicable ethics committee and local regulations Exclusion Criteria: * Age \<18 years * Coronary lesion not meeting the predefined criteria for CTO * No attempted CTO PCI during the procedure * Inability or refusal to provide informed consent when informed consent is required * Withdrawal of consent from participation in the registry

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic total occlusion (CTO) Coronary artery disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    6 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Acıbadem Kent Hospital

    Izmir, Turkey (Türkiye)

  • Dicle University, Faculty of Medicine

    Diyarbakır, Turkey (Türkiye)

  • Inonu University, Faculty of Medicine

    Malatya, Turkey (Türkiye)

  • Necmettin Erbakan University, Faculty of Medicine

    Konya, 42020, Turkey (Türkiye)

  • Siyami Ersek Education and Research Hospital

    Istanbul, Turkey (Türkiye)

  • izmir katip celebi university, Ataturk Education and Research Hospital

    Izmir, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.