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Could probiotics be the next blood pressure remedy?

NCT ID NCT07206303

Disease control Sponsor: The University of Hong Kong Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 01, 2026 · Updated 3 times

Summary

This pilot study is testing whether a Bifidobacterium probiotic supplement can help lower blood pressure in 30 middle-aged Chinese adults with untreated hypertension. Participants will take the probiotic for 12 weeks, and researchers will monitor their blood pressure and other health markers. The goal is to see if this approach is promising enough for a larger trial.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Bifidobacterium-based probiotics
What this could lead to
If it works, this could point toward a simple, natural way to help manage blood pressure without medication.
What could go wrong
This is a very small, early pilot study with only 30 people. It may not show a clear effect, and results may not apply to other groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men or women, aged 40-65 years old. * Chinese residing in Hong Kong. * Clinic SBP ≥130mmHg according to screening measurement at baseline. * Untreated or not on antihypertensive medications within 4 weeks. * Able to provide informed consent. Exclusion Criteria: * Clinic SBP \>165mmHg according to screening measurement at baseline * Known history of diabetes, coronary artery disease, stroke, peripheral artery disease, malignancy or chronic kidney disease * Known history of gastrointestinal disorders including inflammatory bowel disease, irritable bowel syndrome, Helicobacter pylori infection, liver cirrhosis or long-term use of proton pump inhibitors. * Known increased risk of infection due to endovascular or rheumatic heart disease, endovascular grafts, congenital heart defects, endocarditis, mechanical heart valves, and permanent endovascular devices including permanent (not temporary) hemodialysis catheters, pacemakers, or defibrillators. * Known secondary causes of hypertension. * Currently taking omega-3 fatty acid supplements, probiotics, rifaximin, steroids, and antihypertensive agents within 4 weeks. * Currently taking antibiotics within 6 months. * Currently taking anti-oxidant vitamins within 6 months. * Recent travel to tropical areas within 6 months. * Recent bariatric surgery, hepatic resection, intestinal resection/colectomy, or any surgery within 3 months before the study. * Identified higher susceptibility to infections caused by immunosuppression, such as a history of organ or hematopoietic stem cell (HSCs) transplant, neutropenia (ANC \<500 cells/µl), HIV, and CD4 \<200 cells/µl. * Known allergies to any of the components of Bifidobacterium-based probiotics supplement. * Women who are pregnant, or intending to become pregnant, or lactation. * Intending to participate or have participated in a clinical or nutritional intervention study in the last 30 days before study enrolment.

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Conditions

The condition(s) this trial relates to.

hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aged 40 65 years old Bifidobacterium Clinic SBP 130 165MMHG Hong kong chinese Hypertension Probiotics supplement Untreated hypertension

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The University of Hong Kong

    Hong Kong, Hong Kong

More trials for these conditions

Other studies related to the condition(s) this trial covers.