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Could a cheaper, Lower-Dose immunotherapy work just as well for advanced cancers?

NCT ID NCT07576725

First seen May 14, 2026 · Last updated Jun 15, 2026 · Updated 9 times

Summary

This study tests whether giving a lower dose of the immunotherapy drug nivolumab less often can still control advanced cancers that have spread or cannot be removed. About 50 adults with various cancers (like melanoma, lung, or kidney cancer) will receive the treatment. The goal is to see if this approach is effective and could make treatment more accessible worldwide by reducing costs.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Uganda Cancer Institute

    Kampala, 3935, Uganda

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

The condition(s) this trial relates to.

acral lentiginous melanoma basal cell carcinoma cancer cervical cancer cervical carcinoma clear cell renal carcinoma Clear-cell metastatic renal cell carcinoma colorectal neoplasm cutaneous melanoma cutaneous neuroendocrine carcinoma head and neck squamous cell carcinoma Hodgkins lymphoma Kaposi's sarcoma lung neoplasm melanoma metastatic melanoma mucosal melanoma Neoplasm Metastasis non-small cell lung carcinoma renal cell carcinoma skin squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck transitional cell carcinoma Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLINICAL STAGE III CUTANEOUS MELANOMA AJCC V8 CLINICAL STAGE III CUTANEOUS MELANOMA AJCC V8 CLINICAL STAGE III CUTANEOUS MERKEL CELL CARCINOMA AJCC V8 CLINICAL STAGE III CUTANEOUS MERKEL CELL CARCINOMA AJCC V8 CLINICAL STAGE IV CUTANEOUS MELANOMA AJCC V8 CLINICAL STAGE IV CUTANEOUS MERKEL CELL CARCINOMA AJCC V8 HODGKIN LYMPHOMA KAPOSI SARCOMA KAPOSI SARCOMA METASTATIC ACRAL LENTIGINOUS MELANOMA METASTATIC BASAL CELL CARCINOMA METASTATIC CERVICAL CARCINOMA METASTATIC CLEAR CELL RENAL CELL CARCINOMA METASTATIC COLORECTAL CARCINOMA METASTATIC CUTANEOUS MELANOMA METASTATIC HEAD-AND-NECK SQUAMOUS-CELL CARCINOMA METASTATIC KAPOSI SARCOMA METASTATIC LUNG NON-SMALL CELL CARCINOMA METASTATIC MALIGNANT SOLID NEOPLASM METASTATIC MERKEL CELL CARCINOMA METASTATIC MUCOSAL MELANOMA METASTATIC SKIN SQUAMOUS CELL CARCINOMA METASTATIC UROTHELIAL CARCINOMA STAGE III CERVICAL CANCER AJCC V8 STAGE III COLORECTAL CANCER AJCC V8 STAGE III HEAD AND NECK CUTANEOUS SQUAMOUS CELL CARCINOMA AJCC V8 STAGE III HEAD AND NECK CUTANEOUS SQUAMOUS CELL CARCINOMA AJCC V8 STAGE III LUNG CANCER AJCC V8 STAGE III LUNG CANCER AJCC V8 STAGE III RENAL CELL CANCER AJCC V8 STAGE III RENAL CELL CANCER AJCC V8 STAGE IV CERVICAL CANCER AJCC V8 STAGE IV CERVICAL CANCER AJCC V8 STAGE IV COLORECTAL CANCER AJCC V8 STAGE IV COLORECTAL CANCER AJCC V8 STAGE IV HEAD AND NECK CUTANEOUS SQUAMOUS CELL CARCINOMA AJCC V8 STAGE IV LUNG CANCER AJCC V8 STAGE IV RENAL CELL CANCER AJCC V8 UNRESECTABLE ACRAL LENTIGINOUS MELANOMA UNRESECTABLE BASAL CELL CARCINOMA UNRESECTABLE CERVICAL CARCINOMA UNRESECTABLE CLEAR CELL RENAL CELL CARCINOMA UNRESECTABLE COLORECTAL CARCINOMA UNRESECTABLE CUTANEOUS MELANOMA UNRESECTABLE HEAD AND NECK SQUAMOUS CELL CARCINOMA UNRESECTABLE LUNG NON-SMALL CELL CARCINOMA UNRESECTABLE MALIGNANT SOLID NEOPLASM UNRESECTABLE MERKEL CELL CARCINOMA UNRESECTABLE MUCOSAL MELANOMA UNRESECTABLE SKIN SQUAMOUS CELL CARCINOMA UNRESECTABLE UROTHELIAL CARCINOMA