Fred Hutchinson Cancer Center

This study is testing whether doctors can safely lower the dose of a cancer drug called linvoseltamab for people with multiple myeloma that has come back or stopped responding to other treatments. The goal is to see if less frequent, lower doses can still control the cancer while…

This study is testing different remote weight loss programs designed specifically for Latina women who have survived early-stage breast cancer. Researchers want to see if personalized, community-focused programs can help participants lose weight and improve their long-term health…

This early-stage study is testing a personalized vaccine designed to train the immune system to attack a patient's specific cancer. It is for adults with advanced breast cancer, melanoma, or non-small cell lung cancer that has continued to grow despite standard treatments. The ma…

This study is testing a new treatment for adults with high-risk or hard-to-treat blood cancers like leukemia. The treatment involves a radioactive antibody designed to target cancer cells, followed by a stem cell transplant from a partially matched family donor. The main goals ar…

This study is testing a new cell therapy called STEAP1 CART, given with the hormone drug enzalutamide, for men with advanced prostate cancer that has spread and no longer responds to standard treatments. The trial aims to find a safe dose and see if this combination can shrink tu…

This study is testing whether giving fiber supplements to patients undergoing donor stem cell transplants for blood cancers is practical and helpful. Researchers want to see if extra fiber can improve nutrition and support healthy gut bacteria during this intensive treatment. The…

This early-stage study is testing a new combination treatment for adults newly diagnosed with high-risk forms of acute myeloid leukemia (AML) and related blood cancers. The trial combines a standard chemotherapy regimen (FLAG-Ida) with an experimental targeted drug called pivekim…

This pilot study is testing whether extra support helps people who have had surgery for early-stage colorectal cancer get the recommended follow-up tests and scans. The support includes a patient navigator to help schedule appointments and reminders, an interactive website with e…

This study is testing a stem cell transplant procedure that uses a less intense combination of drugs to prepare patients for the transplant. The goal is to cure serious non-cancerous blood and immune system disorders in patients under 50 years old by replacing their faulty bone m…

This study is testing a stem cell transplant from a partially matched family donor for patients with hard-to-treat blood cancers like leukemia and lymphoma. Before the transplant, patients receive chemotherapy and radiation to wipe out their own bone marrow and cancer cells. The …

This study is testing a new, more intensive treatment plan for adults with aggressive blood cancers that are likely to return. The plan involves a combination of chemotherapy drugs and radiation, followed by a stem cell transplant from a donor. The goal is to see if this stronger…

This study aims to develop and test support strategies to help people in Zimbabwe who have both HIV and cancer stay engaged in their HIV care while undergoing cancer treatment. Researchers will first observe 150 patients to identify barriers, then create support strategies with e…

This is a first-in-human study testing a new, personalized cell therapy for people with advanced solid tumors that have spread and contain a specific genetic change called KRAS G12V. Doctors take a patient's own immune cells (T cells), genetically modify them in a lab to recogniz…

This study is testing a new approach to stem cell transplant for adults with aggressive blood cancers that have returned or not responded to treatment. The goal is to find the safest dose of radiation when combined with strong chemotherapy before the transplant, aiming to better …

This study is testing a refined procedure for umbilical cord blood transplants in adults and children with high-risk blood cancers like leukemia and lymphoma. The goal is to see if this optimized approach improves survival and reduces complications compared to standard transplant…

This study is testing if adding a drug called vorinostat makes a newer radioactive cancer treatment work better for men with advanced prostate cancer. The cancer has spread and stopped responding to standard hormone treatments. Researchers want to see if vorinostat can 'turn on' …

This study is testing whether a structured home exercise program can improve how well immunotherapy works for people with non-small cell lung cancer. Researchers want to see if regular aerobic exercise on a stationary bike can boost the body's immune activity, helping the treatme…

This study is testing whether a short course of the antibiotic rifaximin can reduce abnormal blood protein levels in people with IgA MGUS, a condition that can sometimes turn into cancer. Fifty adults with IgA MGUS will be randomly assigned to either take the antibiotic pills for…

This study is testing whether combining two targeted drugs, acalabrutinib and venetoclax, can better control chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or stopped responding to prior treatment. It will involve about 20 adults who hav…

This study is testing a drug called axatilimab for people who develop thick, hard skin after a donor stem cell transplant, a condition called sclerotic chronic graft-versus-host disease (cGVHD). The drug is an antibody given by IV that aims to block cells involved in the scarring…

This study is testing whether removing a specific type of immune cell (called naive T cells) from a donor's stem cells before transplant can prevent chronic graft-versus-host disease in children and young adults with blood cancers. Chronic graft-versus-host disease is a serious c…

This study is testing a two-part treatment for myelofibrosis, a serious bone marrow disease. First, patients take a JAK inhibitor drug. Then, they receive a stem cell transplant from a partially matched donor. The main goal is to see if using the drug for a longer time—before, du…

This study is testing if adding a drug called ruxolitinib to standard treatment can make stem cell transplants safer and more effective for older adults with myelofibrosis or related blood cancers. The main goal is to prevent a dangerous complication where the donor cells attack …

This study is testing if the antiviral drug remdesivir can safely treat RSV (a common respiratory virus) in adults with weakened immune systems. Participants are people with cancer or autoimmune diseases who recently received treatments like stem cell transplants or specialized a…

This study is testing a new, targeted radiation treatment for adults with serious non-cancerous blood diseases who need a stem cell transplant. The treatment uses a radioactive antibody to precisely destroy a patient's own bone marrow cells, making room for healthy donor cells. T…

This study is testing a new experimental drug that delivers radiation directly to cancer cells in patients with high-risk blood cancers like acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The goal is to find the safest and most effective dose of this targete…

This study is testing whether adding the drug ruxolitinib to standard medications can better prevent a dangerous complication called graft-versus-host disease (GVHD) after a bone marrow transplant. It focuses on adults over 40 with acquired aplastic anemia, a serious blood disord…

This study is testing whether giving patients antibody replacement therapy (IVIG) can prevent serious bacterial infections after they receive a powerful cancer treatment called CD19 CAR-T cell therapy. CAR-T therapy can leave patients with low antibody levels, making them vulnera…

This study is testing a new, experimental cell therapy for children under 6 years old with a specific, hard-to-treat type of acute myeloid leukemia (AML) that has come back or not responded to other treatments. Doctors will collect a child's own immune cells, modify them in a lab…

This study is testing whether restricting eating to an 8-hour daily window during cancer treatment improves outcomes and reduces side effects. It will enroll 100 Alaska Native patients with rectal or breast cancer who are receiving standard treatment. Researchers will compare tho…

This study is testing whether a new smartphone app called IndigeQuit is more effective than an existing app at helping American Indians and Alaska Natives quit smoking. Researchers are comparing the two apps in 776 participants who want to quit smoking. The goal is to provide bet…

This study is testing if a faster, higher dose increase of a new drug called sonrotoclax is safe and tolerable for patients with certain blood cancers. It is for adults with chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or mantle cell lymphoma (MCL), inclu…

This study is for people with acute leukemia or myelodysplastic syndrome (MDS) who need a stem cell transplant from a donor. The main goal is to find the best way to reduce a serious complication called graft-versus-host disease (GVHD), where the donor's immune cells attack the p…

This study is testing whether the drug belumosudil can help control chronic graft-versus-host disease (cGVHD), a serious complication where the donor's immune cells attack the patient's body after a stem cell transplant. The trial will enroll 82 adult patients who have early sign…

This early-stage trial is testing a new treatment called CAR T-cell therapy for patients with advanced osteosarcoma, a type of bone cancer that has come back or stopped responding to standard treatments. Doctors take a patient's own immune cells, modify them in a lab to better ta…

This early-phase study is testing the safety and effectiveness of a new drug called ST-067 when given alongside a personalized immune cell therapy (CAR-T) for patients with aggressive large B-cell lymphoma that has come back or not responded to other treatments. The goal is to se…

This study is testing a new, faster treatment plan for adults aged 60 and older with aggressive blood cancers like acute myeloid leukemia (AML). The goal is to see if giving strong chemotherapy followed quickly by a lower-intensity stem cell transplant is safer and more effective…

This early-stage trial is testing a new cell therapy for children and adults whose leukemia has come back or persists after a donor stem cell transplant. Doctors take immune cells (T cells) from the original donor, genetically modify them to better recognize and attack the patien…

This study tests a cooking and nutrition education program designed to help people in Southern New Mexico eat healthier and lower their risk of cancer. Participants attend weekly hands-on cooking classes for six weeks to learn practical skills for preparing nutritious meals. The …

This study is testing a checklist tool designed to help people with sarcoma plan for their future mobility needs. Researchers want to see if using this planning tool is helpful and easy for patients and their caregivers to use. The goal is to improve quality of life by helping pe…

This study is testing two support tools to help people who have survived a blood cancer transplant plan for their future medical care. It will see if using a special website, meeting with a health coach, or both helps patients have important conversations about their care wishes …

This study is testing a new mobile app called PACT that helps people with advanced cancer talk with their loved ones and doctors about the type of medical care they would want if they became too sick to speak for themselves. The trial will enroll 400 patients and their support pe…

This study is testing a new workshop designed to help doctors, nurses, and other clinicians who care for ovarian cancer patients manage work-related stress and burnout. The 4-week program, called HOPE-C, helps participants reframe challenging experiences and build peer support. R…

This study aims to help doctors predict how patients with chronic graft-versus-host disease (cGVHD) will respond to new treatments. Researchers will collect blood samples and survey data from 300 adult patients before and after they start new therapies. The goal is to identify pa…

This study aims to understand if respiratory viruses cause a serious lung disease called bronchiolitis obliterans syndrome (BOS) in people who have received a donor stem cell transplant. Researchers will follow 250 patients at risk for or already diagnosed with BOS for up to two …

This small pilot study is testing whether an 8-week exercise program changes the types of bacteria in the gut of people who have survived stage II or III colorectal cancer. Researchers want to see if these changes in gut bacteria might be one reason why exercise is linked to bett…

This study aims to create new questionnaires to help identify financial hardship in people with Alzheimer's disease and related dementias, and their caregivers. Researchers will interview and survey thousands of patients and caregivers to understand the unique financial strains c…