Fred Hutchinson Cancer Center

This study aims to find the simplest and most effective number of HPV vaccine doses for children and adolescents living with HIV. It compares three different dosing schedules, including testing if a single dose provides good protection. The goal is to make vaccination easier and …

This study is testing whether adding the drug ruxolitinib before, during, and after a stem cell transplant can improve results for people with myelofibrosis, a serious bone marrow cancer. The transplant is currently the only treatment with potential to cure the disease, but it ca…

This study is testing a high-dose chemotherapy and stem cell transplant procedure for people with severe autoimmune diseases that attack the brain, spinal cord, or nerves. The goal is to 'reset' the patient's faulty immune system to stop it from damaging the nervous system. The t…

This study is testing whether taking capsules containing processed, healthy stool (fecal microbiota) can prevent severe graft-versus-host disease (GVHD) in adults who have received a bone marrow transplant. GVHD is a serious and common complication where the donor's immune cells …

This study is testing whether the drug acalabrutinib can help control chronic graft-versus-host disease in adults who have had a stem cell transplant. The trial involves 51 participants whose condition worsened despite steroid treatment. Patients take the medication orally for up…

This study tested a smartphone app designed specifically to help sexual and gender minority (LGBTQ+) young adults in New Mexico quit smoking. The app, called EQQUAL-NM, used a digital avatar guide to teach skills for managing cravings and triggers. Researchers compared two versio…

This study is testing different ways to help childhood and young adult cancer survivors become more physically active and improve their diets. Researchers are comparing several approaches including telehealth sessions with clinicians, personalized goal-setting with social media s…

This study compares two smartphone apps designed to help cancer patients quit smoking. Researchers want to see if the new Quit2Heal app works better than the existing QuitGuide app at helping patients stay smoke-free for a full year. The trial involves 427 cancer patients who cur…

This study compares two types of phone counseling to help overweight adults lose weight. Over 400 participants received weekly coaching calls for a year, focusing on either a newer therapy that teaches acceptance of cravings or a standard behavioral approach. The goal is to see w…

This early-stage study is testing a new drug called DR-18 for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) whose cancer has come back or persisted after a stem cell transplant. The main goals are to find a safe dose and see what side effects it cau…

This study is testing whether a combination of tools can help cancer survivors living in rural areas better manage their health after treatment ends. Participants create their own survivorship care plan and some receive a phone-based education session. The goal is to see if this …

This study aims to find out which of two chemotherapy combinations works better to prepare patients for a donor stem cell transplant. The transplant is a treatment for certain aggressive blood cancers. Researchers are comparing the drugs treosulfan and clofarabine to see which on…

This study tests whether a centralized care coordination system can help more people complete their recommended follow-up appointments after lung cancer screening. It involves over 6,700 current or former heavy smokers at community health centers. The program tracks patients, sen…

This early-stage trial is testing whether adding an investigational drug called NKTR-255 to an approved CAR-T cell therapy makes the treatment more effective for adults with large B-cell lymphoma that has returned or not responded to prior treatments. NKTR-255 is designed to boos…

This study is testing a two-step treatment for myelofibrosis, a serious bone marrow cancer. First, patients take a JAK inhibitor drug (ruxolitinib) for at least 8 weeks to try to reduce symptoms and improve their health. Then, they receive a stem cell transplant from a donor, whi…

This study is testing a new type of personalized cell therapy for patients with B-cell non-Hodgkin lymphoma or chronic lymphocytic leukemia that has come back or not responded to standard treatments. Doctors take a patient's own immune cells, genetically modify them to better tar…

This study aims to find better ways to screen for early signs of cervical cancer in women living with HIV in the Dominican Republic. Researchers are comparing two different HPV testing methods during regular check-ups to see which one more accurately detects precancerous changes.…

This study tests whether providing extra support helps people complete recommended colonoscopies after receiving an abnormal stool test result for colorectal cancer screening. Researchers are comparing standard navigation support against enhanced support that includes an educatio…

This study is testing a new program designed to make it easier for men who have sex with men in Lima, Peru, to get tested for HIV and get connected to care. The program offers different types of HIV tests at social venues and provides a supportive text messaging app. Researchers …

This trial is testing if a drug called ustekinumab can prevent a serious complication called graft-versus-host disease (GVHD) after a stem cell transplant for blood cancers. About 116 patients will receive either the drug or a placebo alongside their standard transplant care. The…

This study is testing a 3-session workshop called HOPE, designed to help women with recurrent ovarian cancer cope with feelings of hopelessness, helplessness, and distress. It compares the workshop to usual care to see if it improves mental health and quality of life. The trial i…

This study is testing whether a 6-week online program that teaches mindful cooking and nutrition can help breast cancer survivors eat healthier. About 50 participants who have finished treatment for early-stage breast cancer will try the program or receive standard care. Research…

This study aims to understand how inherited gene mutations affect prostate cancer risk and outcomes. Researchers are enrolling men with prostate cancer and their family members to collect saliva samples for genetic testing and health information. The goal is to identify patterns …

This study aims to develop better tools to measure whether treatments are working for chronic Graft-versus-Host Disease (GVHD), a serious complication that can occur after stem cell transplants. Researchers are following 383 patients who have started new treatments for chronic GV…

This study aims to improve how doctors measure and understand chronic graft-versus-host disease (GVHD), a serious and long-lasting complication of stem cell transplants. Researchers will follow over 600 people with chronic GVHD for several years, collecting detailed information f…