METASTATIC UROTHELIAL CARCINOMA

This study tests whether a combination of two drugs (pembrolizumab and sacituzumab govitecan) works better than standard chemotherapy for advanced bladder cancer that no longer responds to immunotherapy. About 320 adults with locally advanced or metastatic urothelial cancer will …

This study tests a new treatment for people with advanced bladder cancer that has not responded to standard therapies. The treatment uses specially engineered immune cells (CAR-NK cells) from a healthy donor to target and kill cancer cells. Up to 42 adults will receive the cells …

This study tests the safety of enfortumab vedotin in 100 Indian adults with advanced or spreading bladder cancer (urothelial carcinoma) that has worsened after prior treatment. Participants receive the drug through an IV infusion every 4 weeks. The main goal is to monitor side ef…

This study is for people with metastatic urothelial carcinoma, a type of advanced bladder cancer. It tests combinations of three drugs—sacituzumab govitecan, enfortumab vedotin, and pembrolizumab—to find safe doses and see if they shrink tumors. About 106 participants will join t…

This early-phase study tests a combination of two drugs—cabozantinib and enfortumab vedotin—in people with advanced bladder cancer that has spread or cannot be removed. The goal is to find the best dose and see if the combo is safe and shrinks tumors. About 32 adults who have alr…

This study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors (like breast, lung, or skin cancer). The goal is to see if the combination is safe and helps the immune syst…

This study tests whether a maintenance dose of the immunotherapy drug pembrolizumab can help keep advanced bladder cancer from progressing after an initial combination treatment. About 97 adults with untreated metastatic urothelial carcinoma will receive the combo therapy for 18 …

This early-stage study tests an experimental drug called NX-1607 in adults with advanced cancers that have not responded to standard treatments. The drug works by boosting the immune system to fight tumors. The main goals are to check safety and find the right dose, with a later …

This early-phase trial tests a new drug combination (emavusertib plus pembrolizumab) in 27 adults with advanced bladder cancer that no longer responds to standard immunotherapy. The goal is to find a safe dose and see if the combo can shrink tumors or slow the disease. Participan…

This study tests whether giving the cancer drug nivolumab as a shot at home is as safe and effective as getting it in a clinic. About 50 adults with various cancers will try both settings to see which they prefer and how it affects their quality of life. The goal is to reduce the…

This study tests whether adding cryoablation (freezing cancer cells) to standard radiation therapy provides better pain relief for people with cancer that has spread to the bones. About 40 adults with certain advanced cancers (like prostate, kidney, or colorectal) will be enrolle…

This early-phase study tests an investigational drug called GB-4362 in 37 adults with advanced bladder cancer who are already receiving standard treatments. The drug is designed to neutralize a chemotherapy byproduct that can cause nerve damage and other side effects. The main go…

This study looks at 50 adults with metastatic bladder cancer who started first-line treatment after October 2024. Researchers want to understand why some patients receive platinum-based chemotherapy instead of the newer Enfortumab Vedotin plus Pembrolizumab combination. The goal …

This study looks at how a drug called enfortumab vedotin affects the nerves of people with advanced bladder cancer that has spread. Researchers will measure nerve function with simple tests before and during treatment. The goal is to better understand nerve damage caused by the d…

This study looks at how kidney and bladder cancers use nutrients like sugar and fat to grow. About 600 adults having surgery or a biopsy will receive a special nutrient tracer through an IV. Blood and tissue samples are then analyzed to see how the cancer uses these fuels. Partic…