METASTATIC UROTHELIAL CARCINOMA

This early-stage trial is testing a new type of immune cell therapy for adults with advanced bladder cancer that has stopped responding to standard treatments. Doctors will give patients specially engineered natural killer (NK) cells designed to recognize and attack cancer cells …

This study is testing a two-part treatment for people with advanced bladder cancer that has spread. First, patients receive a combination of two drugs for about 4 months. If the cancer responds, they then continue with one of the drugs as a long-term 'maintenance' therapy for up …

This study is testing a new combination of targeted cancer drugs for people with advanced bladder cancer that has spread. The goal is to find the safest and most effective doses of these drugs, which work in different ways to attack cancer cells. The trial will include people who…

This early-stage study is testing the safety and best dose of a new two-drug combination for people with advanced bladder cancer that has spread and no longer responds to standard immunotherapy. The trial combines an experimental pill (CA-4948) with an existing immunotherapy drug…

This study is testing a new, personalized vaccine designed to teach the body's immune system to recognize and attack a patient's specific cancer. It is being given alongside an existing immunotherapy drug (pembrolizumab) to adults with advanced solid tumors that have spread. The …

This study is testing whether giving a cancer immunotherapy treatment called nivolumab as an injection at home is a safe and practical alternative to receiving it at a clinic. It aims to see if home treatment reduces the burden of travel and time spent in medical facilities, pote…

This study is for people with advanced bladder cancer that has spread and has stopped responding to a common type of immunotherapy. It aims to see if a new combination of two drugs (pembrolizumab and sacituzumab govitecan) works better and helps people live longer than the curren…

This is a first-in-human study testing a new oral drug called NX-1607 in adults with advanced cancers that have stopped responding to standard treatments. The main goal is to find a safe dose and see how well the body handles the drug, both alone and combined with a common chemot…

This study is checking the safety of an existing cancer drug, enfortumab vedotin, specifically for Indian adults with advanced bladder cancer that has spread and has stopped responding to standard treatments. About 100 participants will receive the drug through an IV infusion eve…

This early-stage study is testing a combination of two drugs, cabozantinib and enfortumab vedotin, for advanced bladder cancer that has spread. The main goal is to find the safest and most effective dose. The study will also look for early signs that the treatment can shrink tumo…

This study is testing if adding a freezing procedure (cryoablation) to standard radiation therapy works better to relieve pain from cancer that has spread to the bones. Researchers will compare the combination treatment to radiation alone in 40 patients with advanced cancers. The…

This study aims to understand how kidney and bladder cancers use different nutrients from the blood to grow and survive. Researchers will give some participants a safe, specially labeled nutrient during their scheduled surgery or biopsy to track how the tumor uses it. The goal is…

This study aims to understand how doctors decide between different first treatments for patients with advanced bladder cancer that has spread. Researchers will observe 50 patients who started treatment since October 2024, collecting information about their health characteristics …

This study aims to understand how a bladder cancer drug called enfortumab vedotin affects patients' nerves. Researchers will follow 50 adults with advanced bladder cancer who are starting this treatment. They will use nerve tests to measure changes over 12-15 weeks to learn about…