New combo aims to outsmart resistant bladder cancer
NCT ID NCT06524544
First seen Jun 26, 2026 · Last updated Aug 28, 2026 · Updated 18 times
Summary
This phase III trial tests whether combining two drugs—pembrolizumab (an immunotherapy) and sacituzumab govitecan (a targeted chemotherapy)—works better than standard chemotherapy for people with advanced bladder cancer that has stopped responding to initial immunotherapy. About 320 participants will be randomly assigned to receive either the new combo or standard chemo. The main goal is to see if the combo helps people live longer.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- pembrolizumab and sacituzumab govitecan-hziy
- What this could lead to
- If it works, this combination could offer a new treatment option for people with advanced bladder cancer that no longer responds to standard immunotherapy.
- What could go wrong
- This is a large phase III trial, but the experimental combo may not improve survival more than standard chemotherapy, and side effects from the two drugs together could be significant.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 320 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2025
- Expected to finish
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Dec 2030
An estimate. End dates often move.
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient must be ≥ 18 years of age * Patient must have Eastern Cooperative Oncology Group (ECOG) performance status 0-2. * Patient must have locally advanced (unresectable and/or not amenable to curative intent therapy) or metastatic urothelial cancer * Patient must have histologically proven conventional urothelial carcinoma (UC) of any urinary tract origin \[any histologic subtype except neuroendocrine (small or large cell)\] are permitted so long as tumors include ≥ 1% conventional urothelial histology). NOTE: Pure non-urothelial histology is excluded * Patient must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria. Baseline imaging must be obtained ≤ 35 days prior to randomization * Patient must have the following prior treatment(s). Patient must have had progression on or after the immediate prior anti-cancer therapy * Patient must have had prior exposure to anti-PD(L)1 therapy \[anti -PD(L)1 monotherapy or as a combination regimen in any disease/therapy setting for UC\]. Patients must have received at least 1 dose of anti-PD(L)1 therapy * NOTE: Anti-PD(L)1 therapy does not need to be the most recent therapy received prior to enrollment on this protocol * NOTE: Patient must not have had progression within 12 weeks of starting their first anti-PD(L) 1 therapy, even if anti-PD-(L)1 treatment was given in more than one lines of therapy * Patient must have had ≥ 1 line of systemic therapy given in the advanced/metastatic disease setting, except for patients who had received anti-PD(L)1 + enfortumab vedotin in the localized disease setting (e.g., neoadjuvant and/or adjuvant) and had cancer progression within 12 months from the last systemic therapy dose * For tumors with known FGFR3+ susceptible alteration (for FGFR inhibitor), patients must have received a prior FGFR inhibitor unless contraindicated per physician discretion * Patient must have received prior enfortumab vedotin or any other Nectin-4 directed therapy or other MMAE-containing therapy in any disease/therapy setting unless contraindicated per physician * Patient must have had no prior exposure to Sacituzumab govitecan-hziy or other TROP-2 directed therapies or antibody-drug conjugate that contains topo-isomerase I inhibitor, e.g. trastuzumab deruxtecan * Patient must have Bellmunt score of 0-2. The Bellmunt score assesses a patient's risk and is calculated based on ECOG PS, hemoglobin level and presence of liver metastases * Patient must not have history of grade 3 or higher immune-related adverse events on prior anti-PD1/L1, except for endocrinopathies on adequate hormone therapy repletion and/or clinically insignificant laboratory abnormalities * Patient must have recovered (i.e., ≤ grade 1) from clinically significant AEs due to previously administered systemic therapy agent, except for endocrinopathies on adequate hormone therapy repletion * NOTE: Patients with ≤ grade 2 neuropathy, any grade of alopecia, or any grade of non-clinically significant laboratory abnormality are exceptions to this criterion and are allowed in this trial. * Examples of non-clinically significant laboratory abnormalities include, but are not limited to: * Lymphopenia or monopenia * Lymphocytosis or monocytosis * Increase in amylase or lipase with no clinical correlation * Any other abnormal laboratory findings that have no clinical relevance per the treating investigator. * NOTE: If patient has undergone major surgery, they must have recovered adequately from the toxicity and/or complications from the intervention prior to randomization * Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. All patients of childbearing potential must have a blood test or urine study within 14 days prior to randomization to rule out pregnancy. A patient of childbearing potential is defined as anyone, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months). Patient must not nurse infants while on protocol treatment and for 4 months after the last dose of protocol treatment * Patient must not expect to conceive or father children by using an accepted and effective method(s) of contraception or by abstaining from sexual intercourse for the duration of their participation in the study. Patients of childbearing potential must continue contraceptive method(s) or abstain for 6 months after the last dose of protocol treatment. Patients with partners who could become pregnant should use effective contraception during therapy and for 3 months after the last dose of protocol treatment * Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible * Absolute neutrophil count (ANC) ≥ 1,500/uL (obtained ≤ 14 days prior to randomization) * Platelets ≥ 100,000/uL (obtained ≤ 14 days prior to randomization) * Albumin ≥ 3 g/dL (obtained ≤ 14 days prior to randomization) * Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) (obtained ≤ 14 days prior to randomization) * Aspartate aminotransferase (AST)(serum glutamic oxaloacetic transaminase \[SGOT\]) and alanine aminotransferase (ALT)(serum glutamic pyruvic transaminase \[SGPT\]) ≤ 3 × institutional ULN or ≤ 5.0 x institutional ULN if known liver metastases (obtained ≤ 14 days prior to randomization) * Creatinine clearance (CrCl) ≥ 30 mL/min (obtained ≤ 14 days prior to randomization) NOTE: CrCl is estimated using the Cockcroft-Gault formula (or can be measured by 24-hour urine collection if needed) * Hemoglobin (Hb) ≥ 8.5 g/dl (obtained ≤ 14 days prior to randomization) * Patient must not have a known genetic UGT1A1 deficiency (Gilbert's syndrome). Patients with variant type UGT1A1\*28 allele may have increased levels of SN-38 metabolite (due to reduced SN-38 metabolism and clearance) and are at higher risk for severe adverse events when compared to wild-type. * NOTE: If a patient's UGT1A1 status is unknown, they are eligible to enroll (the study does not require this test as part of screening) * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months of randomization are eligible * For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated * Patients with history of hepatitis C virus (HCV) infection must have been treated and considered cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load * Patients with treated brain metastases are eligible if follow-up brain imaging after central nervous system (CNS)-directed therapy shows no evidence of progression and are not using steroids \> 10 mg of prednisone (or equivalent) daily for brain metastases for at least 7 days prior to randomization * Patients with prior or concurrent malignancy that is not considered clinically significant and whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen (at the discretion of the treating physician) are eligible * Patient must not be on systemic immunosuppressive medication, including steroids (if doses exceed the equivalent of prednisone 10 mg daily). Short courses of steroids, e.g. "burst", which are discontinued prior to randomization are acceptable. Patients on inhaled, intranasal, intra-articular and/or topical steroids are eligible * Patient must be English or Spanish speaking to be eligible for the HRQOL component of the study. * NOTE: Sites cannot translate the associated HRQOL forms
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Locally advanced urothelial carcinoma are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
161 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
Genom att skicka in godkänner du våra Användarvillkor
Locations
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Abbott-Northwestern Hospital
RECRUITINGMinneapolis, Minnesota, 55407, United States
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Allegheny General Hospital
RECRUITINGPittsburgh, Pennsylvania, 15212, United States
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Allegheny Valley Hospital
RECRUITINGNatrona Heights, Pennsylvania, 15065, United States
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Avera Cancer Institute
RECRUITINGSioux Falls, South Dakota, 57105, United States
Contact Email: •••••@•••••
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Avera Cancer Institute - Mitchell
RECRUITINGMitchell, South Dakota, 57301, United States
Contact Email: •••••@•••••
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Avera Cancer Institute at Marshall
RECRUITINGMarshall, Minnesota, 56258, United States
Contact Email: •••••@•••••
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Avera Cancer Institute at Pierre
RECRUITINGPierre, South Dakota, 57501, United States
Contact Email: •••••@•••••
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Avera Cancer Institute at Yankton
RECRUITINGYankton, South Dakota, 57078, United States
Contact Email: •••••@•••••
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Avera Cancer Institute-Aberdeen
RECRUITINGAberdeen, South Dakota, 57401, United States
Contact Email: •••••@•••••
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Benefis Sletten Cancer Institute
RECRUITINGGreat Falls, Montana, 59405, United States
Contact Email: •••••@•••••
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Billings Clinic Cancer Center
RECRUITINGBillings, Montana, 59101, United States
Contact Email: •••••@•••••
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Bozeman Health Deaconess Hospital
RECRUITINGBozeman, Montana, 59715, United States
Contact Email: •••••@•••••
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Cancer Care Center of O'Fallon
RECRUITINGO'Fallon, Illinois, 62269, United States
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Cancer Care Specialists of Illinois - Decatur
RECRUITINGDecatur, Illinois, 62526, United States
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Cancer Center at Saint Joseph's
RECRUITINGPhoenix, Arizona, 85004, United States
Contact Email: •••••@•••••
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Cancer Center of Western Wisconsin
RECRUITINGNew Richmond, Wisconsin, 54017, United States
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Carle BroMenn Medical Center
RECRUITINGNormal, Illinois, 61761, United States
Contact Email: •••••@•••••
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Carle Cancer Center
RECRUITINGUrbana, Illinois, 61801, United States
Contact Email: •••••@•••••
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Carle Cancer Institute Normal
RECRUITINGNormal, Illinois, 61761, United States
Contact Email: •••••@•••••
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Carle Physician Group-Effingham
RECRUITINGEffingham, Illinois, 62401, United States
Contact Email: •••••@•••••
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Carle Physician Group-Mattoon/Charleston
RECRUITINGMattoon, Illinois, 61938, United States
Contact Email: •••••@•••••
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Carle at The Riverfront
RECRUITINGDanville, Illinois, 61832, United States
Contact Email: •••••@•••••
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Central Vermont Medical Center/National Life Cancer Treatment
RECRUITINGBerlin Corners, Vermont, 05602, United States
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Community Hospital of Anaconda
RECRUITINGAnaconda, Montana, 59711, United States
Contact Email: •••••@•••••
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Community Medical Center
RECRUITINGMissoula, Montana, 59804, United States
Contact Email: •••••@•••••
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Community Medical Center
RECRUITINGToms River, New Jersey, 08755, United States
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Cooperman Barnabas Medical Center
RECRUITINGLivingston, New Jersey, 07039, United States
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Crossroads Cancer Center
RECRUITINGEffingham, Illinois, 62401, United States
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Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
RECRUITINGLebanon, New Hampshire, 03756, United States
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Decatur Memorial Hospital
RECRUITINGDecatur, Illinois, 62526, United States
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Duluth Clinic Ashland
RECRUITINGAshland, Wisconsin, 54806, United States
Contact Email: •••••@•••••
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Emory Saint Joseph's Hospital
RECRUITINGAtlanta, Georgia, 30342, United States
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Emory University Hospital Midtown
RECRUITINGAtlanta, Georgia, 30308, United States
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Emory University Hospital/Winship Cancer Institute
RECRUITINGAtlanta, Georgia, 30322, United States
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Essentia Health - Deer River Clinic
RECRUITINGDeer River, Minnesota, 56636, United States
Contact Email: •••••@•••••
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Essentia Health Cancer Center
RECRUITINGDuluth, Minnesota, 55805, United States
Contact Email: •••••@•••••
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Essentia Health Cancer Center-South University Clinic
RECRUITINGFargo, North Dakota, 58103, United States
Contact Email: •••••@•••••
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Essentia Health Hibbing Clinic
RECRUITINGHibbing, Minnesota, 55746, United States
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Essentia Health Saint Joseph's Medical Center
RECRUITINGBrainerd, Minnesota, 56401, United States
Contact Email: •••••@•••••
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Essentia Health Sandstone
RECRUITINGSandstone, Minnesota, 55072, United States
Contact Email: •••••@•••••
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Essentia Health Virginia Clinic
RECRUITINGVirginia, Minnesota, 55792, United States
Contact Email: •••••@•••••
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FHCC Overlake
RECRUITINGBellevue, Washington, 98004, United States
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FHCC at EvergreenHealth
RECRUITINGKirkland, Washington, 98034, United States
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FHCC at Northwest Hospital
RECRUITINGSeattle, Washington, 98133, United States
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Fairview Southdale Hospital
RECRUITINGEdina, Minnesota, 55435, United States
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Forbes Hospital
RECRUITINGMonroeville, Pennsylvania, 15146, United States
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Fred Hutchinson Cancer Center
RECRUITINGSeattle, Washington, 98109, United States
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Geisinger Cancer Center Dickson City
RECRUITINGDickson City, Pennsylvania, 18519, United States
Contact Email: •••••@•••••
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Geisinger Medical Center
RECRUITINGDanville, Pennsylvania, 17822, United States
Contact Email: •••••@•••••
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Geisinger Medical Oncology-Lewisburg
RECRUITINGLewisburg, Pennsylvania, 17837, United States
Contact Email: •••••@•••••
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Geisinger Wyoming Valley/Henry Cancer Center
RECRUITINGWilkes-Barre, Pennsylvania, 18711, United States
Contact Email: •••••@•••••
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Gundersen Lutheran Medical Center
RECRUITINGLa Crosse, Wisconsin, 54601, United States
Contact Email: •••••@•••••
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HSHS Saint Elizabeth's Hospital
RECRUITINGO'Fallon, Illinois, 62269, United States
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HaysMed
RECRUITINGHays, Kansas, 67601, United States
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Hematology Oncology Associates of Fredericksburg Inc
RECRUITINGFredericksburg, Virginia, 22408, United States
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Houston Methodist Cypress Hospital
RECRUITINGCypress, Texas, 77429, United States
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Houston Methodist Hospital
RECRUITINGHouston, Texas, 77030, United States
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Houston Methodist Saint John Hospital
RECRUITINGNassau Bay, Texas, 77058, United States
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Houston Methodist San Jacinto Hospital
RECRUITINGBaytown, Texas, 77521, United States
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Houston Methodist Sugar Land Hospital
RECRUITINGSugar Land, Texas, 77479, United States
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Houston Methodist The Woodlands Hospital
RECRUITINGThe Woodlands, Texas, 77385, United States
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Houston Methodist West Hospital
RECRUITINGHouston, Texas, 77094, United States
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IRMC Cancer Center
RECRUITINGIndiana, Pennsylvania, 15701, United States
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Jefferson Hospital
RECRUITINGJefferson Hills, Pennsylvania, 15025, United States
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Kootenai Clinic Cancer Services - Post Falls
RECRUITINGPost Falls, Idaho, 83854, United States
Contact Email: •••••@•••••
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Kootenai Clinic Cancer Services - Sandpoint
RECRUITINGSandpoint, Idaho, 83864, United States
Contact Email: •••••@•••••
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Kootenai Health - Coeur d'Alene
RECRUITINGCoeur d'Alene, Idaho, 83814, United States
Contact Email: •••••@•••••
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Lawrence Memorial Hospital
RECRUITINGLawrence, Kansas, 66044, United States
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Logan Health Medical Center
RECRUITINGKalispell, Montana, 59901, United States
Contact Email: •••••@•••••
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Louisiana Hematology Oncology Associates LLC
RECRUITINGBaton Rouge, Louisiana, 70809, United States
Contact Email: •••••@•••••
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Margaret R Pardee Memorial Hospital
RECRUITINGHendersonville, North Carolina, 28791, United States
Contact Email: •••••@•••••
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Mary Bird Perkins Cancer Center - Metairie
RECRUITINGMetairie, Louisiana, 70002, United States
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Mary Greeley Medical Center
RECRUITINGAmes, Iowa, 50010, United States
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McFarland Clinic - Ames
RECRUITINGAmes, Iowa, 50010, United States
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McFarland Clinic - Boone
SUSPENDEDBoone, Iowa, 50036, United States
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McFarland Clinic - Jefferson
SUSPENDEDJefferson, Iowa, 50129, United States
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McFarland Clinic - Marshalltown
RECRUITINGMarshalltown, Iowa, 50158, United States
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McFarland Clinic - Trinity Cancer Center
RECRUITINGFort Dodge, Iowa, 50501, United States
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Memorial Hospital East
RECRUITINGShiloh, Illinois, 62269, United States
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Mercy Hospital
RECRUITINGCedar Rapids, Iowa, 52403, United States
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Mercy Hospital
RECRUITINGCoon Rapids, Minnesota, 55433, United States
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Methodist Willowbrook Hospital
RECRUITINGHouston, Texas, 77070, United States
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Missouri Baptist Medical Center
RECRUITINGSt Louis, Missouri, 63131, United States
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Missouri Baptist Sullivan Hospital
RECRUITINGSullivan, Missouri, 63080, United States
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Monmouth Medical Center
RECRUITINGLong Branch, New Jersey, 07740, United States
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Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
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Oncology Associates at Mercy Medical Center
RECRUITINGCedar Rapids, Iowa, 52403, United States
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Park Nicollet Clinic - Saint Louis Park
RECRUITINGSaint Louis Park, Minnesota, 55416, United States
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Parkland Health Center - Farmington
RECRUITINGFarmington, Missouri, 63640, United States
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Parkland Memorial Hospital
RECRUITINGDallas, Texas, 75235, United States
Contact Email: •••••@•••••
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Penn State Milton S Hershey Medical Center
RECRUITINGHershey, Pennsylvania, 17033-0850, United States
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Reading Hospital
RECRUITINGWest Reading, Pennsylvania, 19611, United States
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Regions Hospital
RECRUITINGSaint Paul, Minnesota, 55101, United States
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Robert Wood Johnson University Hospital Somerset
RECRUITINGSomerville, New Jersey, 08876, United States
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Roswell Park Amherst Center
RECRUITINGWilliamsville, New York, 14221, United States
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Roswell Park Cancer Institute
RECRUITINGBuffalo, New York, 14263, United States
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Rutgers Cancer Institute of New Jersey
RECRUITINGNew Brunswick, New Jersey, 08903, United States
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Rutgers New Jersey Medical School
RECRUITINGNewark, New Jersey, 07101, United States
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Saint Francis Medical Center
RECRUITINGCape Girardeau, Missouri, 63703, United States
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Saint Vincent Hospital
RECRUITINGErie, Pennsylvania, 16544, United States
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Sainte Genevieve County Memorial Hospital
RECRUITINGSainte Genevieve, Missouri, 63670, United States
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Salina Regional Health Center
RECRUITINGSalina, Kansas, 67401, United States
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Siteman Cancer Center at Christian Hospital
RECRUITINGSt Louis, Missouri, 63136, United States
Contact Email: •••••@•••••
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Siteman Cancer Center at Saint Peters Hospital
RECRUITINGCity of Saint Peters, Missouri, 63376, United States
Contact Email: •••••@•••••
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Siteman Cancer Center at West County Hospital
RECRUITINGCreve Coeur, Missouri, 63141, United States
Contact Email: •••••@•••••
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Siteman Cancer Center-South County
RECRUITINGSt Louis, Missouri, 63129, United States
Contact Email: •••••@•••••
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Southern Illinois University School of Medicine
RECRUITINGSpringfield, Illinois, 62702, United States
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Springfield Clinic
RECRUITINGSpringfield, Illinois, 62702, United States
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Springfield Memorial Hospital
RECRUITINGSpringfield, Illinois, 62781, United States
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Stony Brook University Medical Center
RECRUITINGStony Brook, New York, 11794, United States
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The James Graham Brown Cancer Center at University of Louisville
RECRUITINGLouisville, Kentucky, 40202, United States
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The University of Kansas Cancer Center - Olathe
RECRUITINGOlathe, Kansas, 66061, United States
Contact Email: •••••@•••••
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ThedaCare Regional Cancer Center
RECRUITINGAppleton, Wisconsin, 54911, United States
Contact Email: •••••@•••••
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Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITINGBrighton, Michigan, 48114, United States
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Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITINGCanton, Michigan, 48188, United States
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Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITINGChelsea, Michigan, 48118, United States
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Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITINGYpsilanti, Michigan, 48197, United States
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Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITINGPontiac, Michigan, 48341, United States
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Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITINGLivonia, Michigan, 48154, United States
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UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITINGOrange, California, 92868, United States
Contact Email: •••••@•••••
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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITINGIrvine, California, 92612, United States
Contact Email: •••••@•••••
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UF Health Cancer Institute - Gainesville
RECRUITINGGainesville, Florida, 32610, United States
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UMass Memorial Medical Center - University Campus
RECRUITINGWorcester, Massachusetts, 01655, United States
Contact Email: •••••@•••••
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UPMC Cancer Center at UPMC Northwest
RECRUITINGSeneca, Pennsylvania, 16346, United States
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UPMC Cancer Center-Uniontown
RECRUITINGUniontown, Pennsylvania, 15401, United States
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UPMC Cancer Center-Washington
RECRUITINGWashington, Pennsylvania, 15301, United States
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UPMC Cancer Centers - Arnold Palmer Pavilion
RECRUITINGGreensburg, Pennsylvania, 15601, United States
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UPMC Hillman Cancer Center
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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UPMC Hillman Cancer Center - Monroeville
RECRUITINGMonroeville, Pennsylvania, 15146, United States
Contact Email: •••••@•••••
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UPMC Hillman Cancer Center Erie
RECRUITINGErie, Pennsylvania, 16505, United States
Contact Email: •••••@•••••
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UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
RECRUITINGMechanicsburg, Pennsylvania, 17050, United States
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UPMC Pinnacle Cancer Center/Community Osteopathic Campus
RECRUITINGHarrisburg, Pennsylvania, 17109, United States
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UPMC-Passavant Hospital
RECRUITINGPittsburgh, Pennsylvania, 15237, United States
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UPMC-Saint Margaret
RECRUITINGPittsburgh, Pennsylvania, 15215, United States
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UT Southwestern Clinical Center at Richardson/Plano
RECRUITINGRichardson, Texas, 75080, United States
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UT Southwestern Simmons Cancer Center - RedBird
RECRUITINGDallas, Texas, 75237, United States
Contact Email: •••••@•••••
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UT Southwestern/Simmons Cancer Center-Dallas
RECRUITINGDallas, Texas, 75390, United States
Contact Email: •••••@•••••
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UT Southwestern/Simmons Cancer Center-Fort Worth
RECRUITINGFort Worth, Texas, 76104, United States
Contact Email: •••••@•••••
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United Hospital
RECRUITINGSaint Paul, Minnesota, 55102, United States
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University Health Truman Medical Center
RECRUITINGKansas City, Missouri, 64108, United States
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University of Illinois
RECRUITINGChicago, Illinois, 60612, United States
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University of Kansas Cancer Center
RECRUITINGKansas City, Kansas, 66160, United States
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University of Kansas Cancer Center - Briarcliff
RECRUITINGKansas City, Missouri, 64116, United States
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University of Kansas Cancer Center - Lee's Summit
RECRUITINGLee's Summit, Missouri, 64064, United States
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University of Kansas Cancer Center - North
RECRUITINGKansas City, Missouri, 64154, United States
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University of Kansas Cancer Center-Overland Park
RECRUITINGOverland Park, Kansas, 66210, United States
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University of Kansas Health System Saint Francis Campus
RECRUITINGTopeka, Kansas, 66606, United States
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University of Kansas Hospital-Westwood Cancer Center
RECRUITINGWestwood, Kansas, 66205, United States
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University of Michigan Health - Sparrow Lansing
RECRUITINGLansing, Michigan, 48912, United States
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University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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University of Vermont Medical Center
RECRUITINGBurlington, Vermont, 05401, United States
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University of Vermont and State Agricultural College
RECRUITINGBurlington, Vermont, 05405, United States
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University of Washington Medical Center - Montlake
RECRUITINGSeattle, Washington, 98195, United States
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UofL Health Medical Center Northeast
RECRUITINGLouisville, Kentucky, 40245, United States
Contact Email: •••••@•••••
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VCU Massey Cancer Center at Stony Point
RECRUITINGRichmond, Virginia, 23235, United States
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VCU Massey Comprehensive Cancer Center
RECRUITINGRichmond, Virginia, 23298, United States
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Virginia Cancer Institute
RECRUITINGRichmond, Virginia, 23229, United States
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Email: •••••@•••••
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West Penn Hospital
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
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West Virginia University Charleston Division
RECRUITINGCharleston, West Virginia, 25304, United States
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Wexford Health and Wellness Pavilion
RECRUITINGWexford, Pennsylvania, 15090, United States
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Other studies related to the condition(s) this trial covers.
- New immunotherapy combo takes aim at bladder and urinary tract cancers
- Sea sponge compound tested against bladder cancer in patients with poor kidney function
- Targeted drug hunts down cancer cells in advanced bladder cancer trial
- New drug option for Hard-to-Treat cancers with FGFR3 mutations
- New bladder cancer drug aims to fight tumors without harming nerves
- New hope for advanced bladder cancer? bevacizumab combo tested