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Can sound waves replace CT scans for aortic aneurysm monitoring?

NCT ID NCT07752654

Knowledge-focused Sponsor: Imperial College London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This study explores whether ultrasound can reliably measure aneurysms in the descending thoracic aorta, the part of the main artery that runs through the chest. Researchers will compare ultrasound measurements with standard CT scans in about 60 adults, including some with known aneurysms and some without. The goal is to see if ultrasound can accurately and consistently measure aneurysm size, which could offer a simpler, radiation-free way to monitor these conditions in the future.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ultrasound imaging (transthoracic ultrasound)
What this could lead to
If ultrasound proves accurate and reliable, it could offer a non-invasive, radiation-free way to monitor descending aortic aneurysms, potentially reducing the need for repeated CT scans.
What could go wrong
This is a small observational study, and ultrasound may not always clearly visualize the aorta due to body shape or other factors. The results will need confirmation in larger studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Apr 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All Participants will receive a single Ultrasound scan as part of this study. All Patients had at least one CT scan of the thoracic aorta prior to the study as part of their standard of care. No additional radiation or invasive imaging techniques will be used in the Thorus study. The data obtained from the CT will be analysed by an independent reviewer and compared with Ultrasound measurements. Participants will be recruited prospectively from a single NHS Trust in London - Imperial College Healthcare NHS Trust.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with diagnosed AAA or other vascular condition attending the vascular scanning department for routine ultrasound and confirmed healthy DTA (Control group). * Patients with known DTAA (including Type B dissection) or patients who had TEVAR previously (Case group). * Patients who have had CT as part of their standard of care. * Patients able to tolerate the scan (Lying in supine position). * Adults aged 18 or over. * Willing to provide consent. Exclusion Criteria: * Patient under 18 years of age. * Previous thoracic surgery or body deformity (severe kyphosis, scoliosis, pleural effusion or chest wall trauma). * Patients without previous imaging of the thoracic aorta. * Life expectancy \<2 years. * Pregnant Women. * Patients unwilling to provide consent or unable to comply with study requirements. * Patients too frail to travel to routine outpatient appointments. * Inability to attend the appointment due to time constraints or other commitments. * Although rare, ultrasound contraindications as described in the scanning protocol are also exclusion criteria.

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Conditions

The condition(s) this trial relates to.

abdominal aortic aneurysm thoracic aortic aneurysm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Accuracy Descending aortic aneurysm Feasibility Reproducibility Ultrasound

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Imperial College Healthcare NHS Trust - St Mary's Hospital

    London, London, W2 1NY, United Kingdom

More trials for these conditions

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