Imperial College London

This study is testing if taking a pill called ASTX727 for 5 days can make a targeted cancer therapy (Lutathera) more effective for people with advanced neuroendocrine tumors. The pill aims to 'reawaken' a specific target on the tumor cells so the Lutathera treatment can work bett…

This large study aims to find out if a newer method of placing pacemaker wires, called 'physiological pacing,' works better than the standard method for people with slow heart rates. It will enroll 2,600 adults who need a pacemaker to see if the newer approach reduces the risk of…

This study is testing if using ultrasound scans to find fatty lumps at insulin injection sites can help people with diabetes manage their blood sugar better. Researchers will train 50 participants with unstable glucose levels to avoid these lumps after an ultrasound scan and prov…

This study is testing if an automated insulin pump system can help people who have both diabetes and advanced kidney disease. The system continuously monitors blood sugar and automatically delivers insulin, aiming to keep levels in a safe range. Researchers will compare this auto…

This study aims to find out which of three specialized pacemaker setups works best for people with heart failure and irregular heartbeats. Researchers will randomly assign 60 participants to receive either the current standard pacemaker or one of two newer approaches. Over six mo…

This study is testing if patients who have a minimally invasive heart valve replacement (TAVI) can go home the same day safely if they use special remote monitoring devices. Researchers want to see if this approach reduces total time spent in the hospital and prevents readmission…

This study is testing if gently cooling a newborn's body for three days can protect their brain and improve their thinking skills later in life. It's for babies who had a difficult birth with low oxygen, leading to a mild brain injury. Researchers will compare babies who receive …

This study is testing whether artificial intelligence (AI) can help doctors find hidden heart problems earlier. Researchers will collect heart test data (ECGs) from about 590 people, using both hospital machines and portable devices like smartwatches. The goal is to see if AI can…

This study is testing a new, moving MRI scanner designed to get clearer pictures of knee injuries like ligament tears. It aims to see if this 'Magic Angle' imaging can show damaged tissues better than standard MRI, which could help doctors plan treatment. The study will scan 20 a…

This study is developing a simple breath test to help detect pancreatic cancer earlier. It will involve about 1,000 people, including those with pancreatic cancer, other pancreatic conditions, and general stomach issues. Researchers will analyze tiny molecules in breath to see if…

This study is testing a new, non-invasive breath test designed to help detect pancreatic cancer earlier. It will involve over 6,000 adults who have been referred by their doctor for possible pancreatic cancer due to vague symptoms. The goal is to see if the test can accurately id…

This large UK study aims to find out if wearing compression stockings in the hospital provides any extra benefit for preventing blood clots when patients are already taking extended blood-thinning medication after high-risk surgery. It will enroll over 8,600 patients to compare t…

This early-stage study is exploring a new approach to help young people (aged 16-25) who struggle with self-harm. Researchers want to see if giving a very low, non-hallucinogenic dose of the psychedelic psilocybin can make a specific mental imagery therapy more effective. The goa…

This study aims to understand how the body processes and breaks down a common anti-inflammatory steroid medication called prednisolone when given at high doses. Researchers will measure drug levels in the blood and urine of 120 patients who are taking high doses of prednisolone f…

This is a large-scale, observational study creating a global registry for people with familial hypercholesterolemia (FH), a genetic condition causing very high cholesterol. It will collect and analyze existing, anonymous health data from over 75,000 participants across nearly 60 …

This study creates an online registry to follow 10,000 adults with cardiomyopathy or myocarditis over time. Participants share health information and provide saliva samples for genetic testing. Researchers aim to better understand these heart conditions by tracking outcomes like …

This study aims to understand when chest pain starts during different heart artery blockages. Researchers will work with 60 people who have stable chest pain and two narrowed heart arteries. During a heart catheter procedure, they'll temporarily block each artery while participan…

This UK study aims to understand how caring for a very premature baby affects families' wellbeing, finances, and daily life over the first year at home. It focuses on babies with and without a serious bowel condition called necrotising enterocolitis (NEC). Researchers will follow…

This study follows 600 adults over 65 for up to 12 years to understand the earliest brain changes in Alzheimer's disease, long before memory problems become obvious. Participants will undergo regular memory tests and blood draws to track their thinking skills and look for biologi…

This study aims to see if changes in what people buy—like pain relief or digestive aids—can serve as an early warning sign for certain cancers. Researchers will compare the shopping history of 1,450 recently diagnosed cancer patients with 1,450 people without cancer, using up to …