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Brain scan study aims to solve shunt surgery mystery in elderly

NCT ID NCT07103681

Knowledge-focused Sponsor: Imperial College London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at 100 older adults with normal pressure hydrocephalus (NPH) to find out why some get better after a shunt surgery and others do not. Researchers will use brain scans, blood tests, and wearable monitors to check for nerve damage and signs of dementia. The goal is to better predict who will benefit from surgery and improve quality of life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Feb 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with hydrocephalus, neurodegenerative disease and healthy controls will be recruited by Dr Chris Carswell at Imperial College Hospital NHS Trust.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Group 1 (communicating hydrocephalus): Inclusion Criteria: * Adult patients \>60 * With gait apraxia * With or without cognitive impairment * Urinary dysfunction * Communicating Hydrocephalus Exclusion Criteria: * Asymptomatic hydrocephalus * High pressure-hydrocephalus * Serious head injury within 5 years of presentation or a clear secondary cause (e.g. brain infection) * History of childhood gait disturbance * Clear alternative explanation for symptoms (e.g. Parkinson's disease with limb rigidity, peripheral neuropathy with sensory ataxia, cervical myelopathy). * Too frail for shunt surgery * Medically unstable (e.g. active angina, respiratory disease, recurrent delirium, active epilepsy). * Unable to tolerate MRI brain imaging * Unable to have a lumbar puncture * Immobile * Unable to attend the hospital for study visits Group 2 (asymptomatic and non-hydrocepahlus dementia and healthy controls): Inclusion Criteria (Any of the following): * Healthy Carers * Members of the Public * Staff of Imperial College/ICHT * Non-NPH Dementias (including Alzheimer's disease or vascular dementia) * Asymptomatic Hydrocephalus Exclusion Criteria: \- Unable to attend the hospital for study visits

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Conditions

The condition(s) this trial relates to.

Alzheimer disease communicating hydrocephalus hydrocephalus normal pressure hydrocephalus vascular dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Normal pressure hydrocephalus

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Imperial College Healthcare NHS Trust

    RECRUITING

    London, W6 8RF, United Kingdom

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