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New pacemaker approach could reduce heart failure risk

NCT ID NCT05815745

Disease control Sponsor: Imperial College London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 4 times

Summary

This study compares two pacemaker methods for people with a slow heart rate: standard right ventricular pacing and a newer 'physiological pacing' that targets the heart's natural conduction system. Researchers will track 2,600 participants over time to see which method better prevents death and heart failure. The goal is to find a safer long-term pacing option.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Pacemaker (physiological pacing or right ventricular pacing)
What this could lead to
If successful, this could show that physiological pacing reduces the risk of death and heart failure compared to standard pacing.
What could go wrong
This is a large trial, but results may not apply to all patients. The new pacing method is more complex and may have higher risks during implantation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 2,600 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2023

Expected to finish

Jun 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

We will recruit patients who are referred for clinically indicated pacemaker implantation Inclusion Criteria: 1\. Adults aged over 18 with left ventricular ejection fraction \>35% and one or more of the following guideline based ventricular pacing indications: 1. Permanent or intermittent 3rd degree AV block 2. Permanent or intermittent Mobitz type II AV block 3. First Degree AV block with a pacing indication 4. Slow chronic Atrial Fibrillation or Proposed AV node ablation 5. Bifascicular block with a pacing indication 6. Trifascicular block with a pacing indication 7. Wenckebach with a pacing indication Exclusion Criteria: 1. Patients who are likely to only need occasional ventricular pacing, i.e. those with isolated sick sinus syndrome. 2. Pregnant women. 3. Unable to provide informed consent. 4. Those with comorbidity leading to a life expectancy \<1year.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation Bradycardia first-degree atrioventricular block Mobitz type I atrioventricular block Mobitz type II atrioventricular block third-degree atrioventricular block

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bradycardia His bundle pacing Left bundle branch area pacing PACING Right ventricular pacing

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    45 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Aberdeen Royal Infirmary

    RECRUITING

    Aberdeen, United Kingdom

  • Beacon Hospital

    RECRUITING

    Dublin, Ireland

  • Bristol Heart Institute

    RECRUITING

    Bristol, United Kingdom

  • Croydon

    RECRUITING

    Croydon, United Kingdom

  • Derriford Hospital

    RECRUITING

    Plymouth, United Kingdom

  • East Surrey

    RECRUITING

    Redhill, United Kingdom

  • Forth Valley Royal Hospital

    RECRUITING

    Larbert, United Kingdom

  • Glenfield Hospital

    RECRUITING

    Leicester, United Kingdom

  • Good Hope Hospital

    RECRUITING

    Birmingham, United Kingdom

  • Great Western

    RECRUITING

    Swindon, United Kingdom

  • Hammersmith Hospital

    RECRUITING

    London, United Kingdom

  • James Cook Hospital

    RECRUITING

    Middlesbrough, United Kingdom

  • John Radcliffe Hospital

    RECRUITING

    Oxford, United Kingdom

  • Kettering Hospital

    RECRUITING

    London, United Kingdom

  • King's College Hospital

    RECRUITING

    London, United Kingdom

  • King's Mill Hospital

    RECRUITING

    Nottingham, United Kingdom

  • Leeds Teaching Hospital

    RECRUITING

    Leeds, United Kingdom

  • Liverpool Heart and Chest Hospital

    RECRUITING

    Liverpool, United Kingdom

  • Medway Maritime Hospital

    RECRUITING

    Gillingham, United Kingdom

  • Morriston Hospital

    RECRUITING

    Swansea, United Kingdom

  • Musgrove Park Hospital

    RECRUITING

    Taunton, United Kingdom

  • Northern General

    RECRUITING

    Sheffield, United Kingdom

  • Nottingham City Hospital

    RECRUITING

    Nottingham, United Kingdom

  • Queen Alexandra Hospital

    RECRUITING

    Portsmouth, United Kingdom

  • Queen Elizabeth Hospital

    RECRUITING

    Birmingham, United Kingdom

  • Queen's Hospital

    RECRUITING

    Barking, United Kingdom

  • Rotherham General Hospital

    RECRUITING

    Rotherham, United Kingdom

  • Royal Berkshire

    RECRUITING

    Reading, United Kingdom

  • Royal Free London/ Barnet Hospital

    RECRUITING

    London, United Kingdom

  • Royal Infirmary of Edinburgh

    RECRUITING

    Edinburgh, United Kingdom

  • Royal Papworth Hospital

    RECRUITING

    Cambridge, United Kingdom

  • Royal SUSSEX County Hospital

    RECRUITING

    Brighton, United Kingdom

  • Southampton

    RECRUITING

    Southampton, United Kingdom

  • St Bartholomew's Hospital

    RECRUITING

    London, United Kingdom

  • St Richard's Hospital

    RECRUITING

    Chichester, United Kingdom

  • Torbay Hospital

    RECRUITING

    Torquay, United Kingdom

  • UHS Worthing

    RECRUITING

    Worthing, United Kingdom

  • Univerisity Medical Centre Ljubljana

    RECRUITING

    Ljubljana, Slovenia

  • University Hospital Coventry

    RECRUITING

    Coventry, United Kingdom

  • University Hospital Dorset

    RECRUITING

    Bournemouth, United Kingdom

  • Victoria Hospital

    RECRUITING

    Fife Keith, United Kingdom

  • Watford General Hospital

    RECRUITING

    London, United Kingdom

  • Wexham Park Hospital

    RECRUITING

    Slough, United Kingdom

  • Wycombe Hospital

    RECRUITING

    High Wycombe, United Kingdom

  • York Hospital

    RECRUITING

    York, United Kingdom

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Other studies related to the condition(s) this trial covers.