Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Could a simple pacemaker switch ease heart failure?

NCT ID NCT06052475

Disease control Sponsor: Imperial College London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial investigates whether people with heart failure and a traditional right ventricular pacemaker feel better and have stronger hearts after switching to a more natural pacing method, such as His bundle or biventricular pacing. Participants will have their pacemaker upgraded and then spend time in both pacing modes, blinded, to compare symptoms, heart function, and quality of life. The study aims to see if a simple device change can reverse pacing-induced heart damage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Physiological pacing upgrade (conduction system pacing or biventricular pacing device)
What this could lead to
If successful, this could show that upgrading pacemakers to a more natural pacing method improves heart function and daily well-being for people with pacing-induced cardiomyopathy.
What could go wrong
This is a relatively small crossover trial, and the benefits may not be large or apply to all patients. The procedure itself carries risks like infection or lead displacement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 155 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2023

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Patients with an RV pacemaker and LVEF 35-50% and a high burden of right ventricular pacing (\>40%) who are clinically indicated for a cardiac resynchronisation therapy upgrade procedure and: 1. EF reduced by \>5% of increase in LVESV by 10ml since implant 2. NT-proBNP \>250ng/L in sinus rhythm 3. NT-proBNP \> 750 Ng/L if AF 4. Left atrial volume index \> 30ml/m2 5. Regular loop diuretics prescribed 6. Decline in daily patient activity by \>1 hour per day since implant 7. Decrease in device measured thoracic impedance 8. Patient reported decline in functional class or exercise tolerance Exclusion Criteria: * Those unable to provide informed consent * Patients under age 18 * Pregnant women

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Heart failure are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure Pacing induced cardiomyopathy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    12 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Croydon University Hospital - Croydon Health Services

    RECRUITING

    Croydon, United Kingdom

  • Glenfield Hospital

    RECRUITING

    Leicester, United Kingdom

  • Great Western Hospitals

    RECRUITING

    Swindon, United Kingdom

  • Hammersmith Hospital

    RECRUITING

    London, United Kingdom

  • King's College Hospital

    RECRUITING

    London, United Kingdom

  • Oxford University Hospitals

    RECRUITING

    Oxford, United Kingdom

  • Royal Papworth Hospital

    RECRUITING

    Cambridge, United Kingdom

  • St Bartholomew's Hospital - Barts Health NHS Trust

    RECRUITING

    London, United Kingdom

  • St. Richard's Hospital - University Hospitals Sussex

    RECRUITING

    Chichester, United Kingdom

  • University Hospitals Coventry and Warwickshire NHS Trust,

    RECRUITING

    Coventry, United Kingdom

  • University Hospitals Southampton

    RECRUITING

    Southampton, United Kingdom

  • Worthing Hospital - University Hospitals Sussex

    RECRUITING

    Worthing, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.