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Pinpointing the dose: can phenylephrine keep blood pressure steady during cesarean birth?

NCT ID NCT07824713

Prevention Sponsor: Peking University People's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Spinal anesthesia for cesarean delivery often causes a sudden drop in blood pressure. Researchers are testing different infusion rates of phenylephrine, a drug that narrows blood vessels, to find the dose that prevents this drop in most women. The trial enrolls 200 women with full-term singleton pregnancies scheduled for elective cesarean delivery. Each woman is randomly assigned to lie either flat on her back or tilted 15 degrees to the left, and within each position to one of four phenylephrine infusion rates. The goal is to identify the dose that works for 50% and 90% of women in each position.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
phenylephrine, a drug that tightens blood vessels to raise blood pressure
What this could lead to
If it works, this could give anesthesiologists precise dosing guidance to keep blood pressure stable during cesarean delivery, protecting both mother and baby.
What could go wrong
The trial is small and focuses on healthy, full-term pregnancies, so the dosing may not apply to higher-risk deliveries. Phenylephrine can also lower heart rate, and the optimal dose may differ by position.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Singleton term pregnancy scheduled for elective cesarean delivery 2. Height 150-180 cm 3. ASA physical status II-III 4. Body mass index \< 35 kg/m2 Exclusion Criteria: 1. Transverse lie or suspected macrosomia 2. Uterine abnormalities (e.g., large uterine fibroids, bicornuate uterus) 3. Polyhydramnios 4. Ruptured membranes or oligohydramnios 5. Fetal growth restriction 6. Gestational or pregestational hypertension, diabetes mellitus, or preeclampsia 7. Diseases associated with autonomic neuropathy (e.g., diabetes mellitus \> 10 years) or renal failure 8. Contraindications to spinal anesthesia 9. Refusal to provide written informed consent-

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Conditions

The condition(s) this trial relates to.

hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypotension after spinal anesthesia

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Department of Anesthesiology，Xuzhou HeJia Hospital, Xuzhou, Jiangsu, China

    Xuzhou, Jiangsu, 221000, China

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