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Can a new migraine drug stop the dizzy spells?

NCT ID NCT07751497

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This trial tests whether rimegepant, a newer migraine medication, works as well as flunarizine, an older preventive, for reducing days with moderate-to-severe dizziness in people with vestibular migraine. About 400 adults aged 18 to 75 will take one of the two drugs daily for 12 weeks and track their symptoms in a diary. The goal is to see if rimegepant can match flunarizine in cutting down the number of dizzy days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Rimegepant (a CGRP-blocking drug) compared with flunarizine (a calcium-channel blocker)
What this could lead to
If rimegepant proves as good as flunarizine, it could offer a newer, potentially better-tolerated option to prevent dizzy spells in people with vestibular migraine.
What could go wrong
This is a phase 2 trial, so results are preliminary. Rimegepant might not match flunarizine's effectiveness, and side effects could differ. The open-label design (participants know their treatment) may also bias results.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Apr 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female subjects aged 18 to 75 years; * Diagnosis of definite vestibular migraine per Bárány society criteria: A. At least 5 episodes with vestibular symptoms of moderate or severe intensity, lasting 5 min to 72 hours; B. Current or previous history of migraine with or without aura according to the International Classification of Headache Disorders (ICHD); C. One or more migraine features with at least 50% of the vestibular episodes: 1. headache with at least two of the following characteristics: * one sided location * pulsating quality * moderate or severe pain intensity * aggravation by routine physical activity 2. photophobia and phonophobia; 3. visual aura; D. Not better accounted for by another vestibular or ICHD diagnosis. * Baseline (day 0 to 28) moderate or severe vestibular symptom days ≥ 4; * 80% adherence or better to electronic diary(eDiary) during observational phase * VM-PATHI2(Vestibular Migraine Patient Assessment Tool and Handicap Inventory) score \> 25 at screening and baseline visit; * Written informed consent must be obtained before patient enrolled; * Fluency in local main language; * Access to email, and cell phone. Exclusion Criteria: * Vestibular hypofunction (unilateral or bilateral); * History of ear surgery (other than ear tubes); * Other vestibular diagnoses (excluding treated benign paroxysmal positional vertigo (BPPV)), including Meniere's disease, superior semicircular canal dehiscence syndrome, vestibular neuritis, persistent postural-perceptual dizziness, unilateral or bilateral vestibular hypofunction, cerebellar or brainstem disorders, multiple sclerosis, or motion sickness; * Prior or current use of any prophylactic medication targeting the calcitonin gene-related peptide (CGRP); * Prior or current treatment with flunarizine; * Individuals are allergic to rimegepant sulfate oral disintegrating tablets or any excipients of rimegepant sulfate oral disintegrating tablets; * Pregnant women, breastfeeding women, or those unwilling to use approved contraceptive methods during the study participation; * History of serious medical or psychiatric disease, at the discretion of the treating physician (including significant coronary artery disease, peripheral vascular disease, cerebrovascular disease, kidney disease, liver disease, and uncontrolled psychiatric disease or past psychiatric hospitalization); * A history of severe medical or psychiatric conditions (including significant coronary artery disease, peripheral vascular disease, cerebrovascular disease, renal disease, liver disease, Raynaud's disease, uncontrolled psychiatric disorders, or previous psychiatric hospitalizations) as determined by the treating physician; * A history of mania, psychosis, or suicidal ideation; * A history of drug or alcohol abuse within the 12 months prior to screening, based on the subject's medical records or self-report; * Individuals who have received head, face, or neck botulinum toxin injections (such as Dysport®, Botox®, Xeomin®, Myobloc®, and JeuveauTM) within 4 months before screening or are scheduled for such injections during the study period; * Unwilling to use approved form of birth control during the study; * Other conditions judged by the investigator as unsuitable for inclusion.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No.88 Jiefang Road

    Hangzhou, Zhejiang, 310000, China

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