Scientists probe sonic hedgehog pathway for clues to brain AVM treatment
NCT ID NCT07676721
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This study investigates the role of the Sonic Hedgehog signaling pathway in brain arteriovenous malformations (AVMs), abnormal tangles of blood vessels that can cause bleeding or stroke. Researchers will analyze leftover brain tissue from 20–30 adults undergoing AVM surgery and compare it to non-pathological tissue from 10–15 epilepsy surgery patients. Using advanced techniques like gene and protein analysis, they aim to identify molecular differences that could point to new drug targets for this condition.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this research could identify new drug targets for treating brain arteriovenous malformations, potentially leading to therapies that reduce the need for surgery.
- What could go wrong
- This is an early-stage observational study analyzing tissue samples, not testing a treatment. The findings may not translate into effective therapies, and animal model studies may not predict human outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 45 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Aug 2026
An estimate. Start dates often move.
- Expected to finish
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Aug 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Adults ≥18 years undergoing neurosurgical intervention with resection of AVM or non-pathological cortical tissue (controls).
- Ages
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18 years and older
- Sex
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Anyone
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients aged 18 years or older undergoing neurosurgical resection who provide written informed consent for research use of residual tissue. Exclusion Criteria: * Tissue with extensive necrosis or contamination, lack of valid consent, or known infectious agents that preclude safe handling.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, Rome, 00168, Italy